A neuronal model of Alzheimer's disease: An insight into the mechanisms of oxidative stress–mediated mitochondrial injury

• Published in: Neuroscience Vol. 153; no. 1; pp. 120 - 130
• Main Authors: Sompol, P, Ittarat, W, Tangpong, J, Chen, Y, Doubinskaia, I, Batinic-Haberle, I, Abdul, H.M, Butterfield, D.A, St. Clair, D.K
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 22.04.2008; Elsevier
• Subjects: Aldehydes - metabolism; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Alzheimer's disease; Amyloid beta-Protein Precursor - genetics; Animals; Animals, Newborn; APP/PS1; Biological and medical sciences; Brain - metabolism; Brain - physiopathology; Cell Respiration - drug effects; Cell Respiration - physiology; Cells, Cultured; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Models, Animal; Fundamental and applied biological sciences. Psychology; Humans; Medical sciences; Membrane Potential, Mitochondrial - genetics; Metalloporphyrins - pharmacology; Mice; Mice, Transgenic; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondrial Diseases - metabolism; Mitochondrial Diseases - physiopathology; MnSOD; Mutation - genetics; Neurology; Neurons - drug effects; Neurons - metabolism; oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - genetics; Presenilin-1 - genetics; Protein Carbonylation - physiology; SOD mimetic; Superoxide Dismutase - metabolism; Superoxide Dismutase-1; Tyrosine - analogs & derivatives; Tyrosine - metabolism; Vertebrates: nervous system and sense organs; β-amyloid; RCR; APP; nuclear factor kappa B; respiratory control ratio; SDS, sodium dodecyl sulfate; 4-hydroxy-2-trans-nonenal; PS1; BSA; NF-κB; CuZnSOD; MnTE-2-PyP 5; 4-HNE; amyloid precursor protein; copper–zinc superoxide dismutase; 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine iodide; manganese superoxide dismutase; nitroblue tetrazolium; 3-nitrotyrosine; Alzheimer's disease; β-amyloid; NBT; AD; hydroxynonenal; SOD mimetic; presenilin 1; MCI; APP/PS1; MnSOD; 3-NT; mild cognitive impairment; oxidative stress; bovine serum albumin; HNE; JC-1; Oxidative stress; Nervous system diseases; Alzheimer disease; Cerebral disorder; Mitochondria; β Amyloid protein; Central nervous system disease; Degenerative disease; Models; Lesion

Abstract Alzheimer's disease (AD) is associated with β-amyloid accumulation, oxidative stress and mitochondrial dysfunction. However, the effects of genetic mutation of AD on oxidative status and mitochondrial manganese superoxide dismutase (MnSOD) production during neuronal development are unc...