Origin of the HIV-1 group O epidemic in western lowland gorillas

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 11; pp. E1343 - E1352
• Main Authors: D’arc, Mirela, Ayouba, Ahidjo, Esteban, Amandine, Learn, Gerald H., Boué, Vanina, Liegeois, Florian, Etienne, Lucie, Tagg, Nikki, Leendertz, Fabian H., Boesch, Christophe, Madinda, Nadège F., Robbins, Martha M., Gray, Maryke, Cournil, Amandine, Ooms, Marcel, Letko, Michael, Simon, Viviana A., Sharp, Paul M., Hahn, Beatrice H., Delaporte, Eric, Ngole, Eitel Mpoudi, Peeters, Martine
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 17.03.2015; National Acad Sciences
• Series: PNAS Plus
• Subjects: Acquired immune deficiency syndrome; AIDS; Animals; Animals, Wild - virology; Antibodies, Viral - immunology; Biological Evolution; Biological Sciences; Cameroon; Cameroon - epidemiology; crossing; Cytidine Deaminase - metabolism; emerging diseases; Epidemics; Feces - virology; Genetic diversity; Genetic Variation; Genome - genetics; Geography; Gorilla; Gorilla gorilla - virology; Gorillas; HIV; HIV-1 - physiology; human diseases; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Life Sciences; Molecular Sequence Data; Nucleic acids; Pan troglodytes; pandemic; Phylogenetics; Phylogeny; PNAS Plus; Proteolysis; risk; Santé publique et épidémiologie; Sequence Analysis, DNA; Simian Acquired Immunodeficiency Syndrome - epidemiology; Simian Acquired Immunodeficiency Syndrome - immunology; Simian Acquired Immunodeficiency Syndrome - virology; Simian immunodeficiency virus; Simian Immunodeficiency Virus - immunology; viruses; Cameroon; Gabon; Uganda; Africa; HIV-1; gorilla; AIDS; SIVgor; zoonotic transmission

Significance Understanding emerging disease origins is important to gauge future human infection risks. This is particularly true for the various forms of the AIDS virus, HIV-1, which were transmitted to humans on four independent occasions. Previous studies identified chimpanzees in southern Camero...