Mucosal IgA responses in influenza virus infections; thoughts for vaccine design

• Published in: Vaccine Vol. 30; no. 40; pp. 5893 - 5900
• Main Authors: van Riet, Elly, Ainai, Akira, Suzuki, Tadaki, Hasegawa, Hideki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 31.08.2012; Elsevier Limited
• Subjects: Adaptive Immunity; Allergy and Immunology; Animals; Antibodies; Avian flu; B-Lymphocytes - immunology; CD4 antigen; CD4-positive T-lymphocytes; CD4-Positive T-Lymphocytes - immunology; CD8 antigen; CD8-positive T-lymphocytes; Cross Protection; genome; Genomes; Human subjects; Humans; IgA; Immune system; immunity; Immunity, Humoral; Immunity, Mucosal; Immunoglobulin A; Immunoglobulin A - immunology; Immunologic Memory; Immunological memory; Immunology; Infection; Infections; Influenza; Influenza Vaccines - immunology; Influenza virus; Influenza, Human - immunology; Lymphocytes B; Lymphocytes T; Medical research; Memory cells; Mice; Mucosa; Mucosal immunity; Orthomyxoviridae; Orthomyxoviridae - immunology; Orthomyxoviridae Infections - immunology; Point mutation; respiratory system; Respiratory tract; Reviews; Studies; surface antigens; vaccination; Vaccine; vaccine development; Vaccines; Viruses; Antibodies; IgA; Vaccine; Cross-protection; Influenza; Mucosa

The current challenge in influenza vaccine design is to induce long-lasting protection not only against the vaccine strain, but also against drifted (point mutations in the surface antigens HA or NA) and even shifted (exchange of genome segments) strains. Several immune mediators that can induce cro...