Inhibiting nuclear factor erythroid 2 related factor 2-mediated autophagy in bovine mammary epithelial cells induces oxidative stress in response to exogenous fatty acids

• Published in: Journal of animal science and biotechnology Vol. 13; no. 1; p. 48
• Main Authors: Chang, Renxu, Sun, Xudong, Jia, Hongdou, Xu, Qiushi, Dong, Zhihao, Tang, Yan, Luo, Shengbin, Jiang, Qianming, Loor, Juan J., Xu, Chuang
• Format: Journal Article
• Language: English
• Published: England BioMed Central 10.04.2022; BMC
• Subjects: Adenoviruses; Antibiotics; antioxidant activity; Antioxidants; autophagosomes; Autophagy; Biotechnology; Bovine mammary epithelial cells; Catalase; Cattle; Cell activation; Cell culture; dose response; early lactation; Epithelial cells; Epithelium; Fatty acids; Glutathione; Glutathione peroxidase; Homeostasis; Lactation; Lymphocytes; malondialdehyde; Mammary gland; Metabolism; NFE2L2; Oxidative stress; Penicillin; Peroxidase; Phagosomes; Phosphatidylethanolamine; Pretreatment; Proteins; Reactive oxygen species; siRNA; Sulforaphane; Superoxide dismutase; Translocation; Beijing China; New York; Grand Island New York; United States > US; China; Japan; Oxidative stress; Bovine mammary epithelial cells; Autophagy; NFE2L2

In early lactation, bovine mammary epithelial cells undergo serious metabolic challenges and oxidative stress both of which could be alleviated by activation of autophagy. Nuclear factor erythroid 2 related factor 2 (NFE2L2), a master regulator of cellular redox homeostasis, plays an important role...