Oxidative stress in the pathology and treatment of systemic lupus erythematosus

• Published in: Nature reviews. Rheumatology Vol. 9; no. 11; pp. 674 - 686
• Main Author: Perl, Andras
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2013; Nature Publishing Group
• Subjects: 692/420/2780; 692/699/1670/122/1613; 692/699/1670/1613; Acetylcysteine; Animal models; Animals; Antigens; Antioxidants; Antioxidants - therapeutic use; Autoantigens; Autoimmunity - drug effects; Autoimmunity - physiology; Care and treatment; Comorbidity; Cytotoxicity; Drug therapy; Glutathione; Health aspects; Humans; Immune system; Kinases; Lupus; Lupus Erythematosus, Systemic - drug therapy; Lupus Erythematosus, Systemic - metabolism; Lupus Erythematosus, Systemic - pathology; Lymphocytes T; Medicine & Public Health; Oxidation; Oxidative stress; Oxidative Stress - physiology; Pathogenesis; Pathology; Patients; Physiological aspects; review-article; Rheumatology; Signal transduction; Systemic lupus erythematosus; T cells; Toxicity; United States

Key Points Oxidative stress—generated through multiple mechanisms in a cell-type-specific manner—is a substantial contributor to disease pathogenesis, organ damage and comorbidities in patients with systemic lupus erythematosus (SLE) Pathways of oxidative pathogenesis, such as oxidative modification...