Warburg Effects in Cancer and Normal Proliferating Cells: Two Tales of the Same Name

• Published in: Genomics, proteomics & bioinformatics Vol. 17; no. 3; pp. 273 - 286
• Main Authors: Sun, Huiyan, Chen, Liang, Cao, Sha, Liang, Yanchun, Xu, Ying
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.06.2019; Department of Biostatistics, School of Medicine, Indiana University, Indianapolis, IN 46202, USA%MOE Key Laboratory of Symbolic Computation and Knowledge Engineering, College of Computer Science and Technology,Jilin University, Changchun 130012, China; Computational Systems Biology Lab, Department of Biochemistry and Molecular Biology and Institute of Bioinformatics,University of Georgia, Athens, GA 30602, USA%Faculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, China%Computational Systems Biology Lab, Department of Biochemistry and Molecular Biology and Institute of Bioinformatics,University of Georgia, Athens, GA 30602, USA; Zhuhai Laboratory of MOE Key Laboratory of Symbolic Computation and Knowledge Engineering, Zhuhai College of Jilin University, Zhuhai 519041, China; The China-Japan Union Hospital, Jilin University, Changchun 130033, China; MOE Key Laboratory of Symbolic Computation and Knowledge Engineering, College of Computer Science and Technology,Jilin University, Changchun 130012, China; Elsevier; Oxford University Press
• Subjects: adenosine triphosphate; Adenosine Triphosphate - metabolism; Cancer; cell division; Cell Line, Tumor; Cell Proliferation; Cytosol - metabolism; Fenton reaction; Gene Expression Regulation; glycolysis; Glycolysis - genetics; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; hydrolysis; intracellular space; Intracellular Space - metabolism; Iron; lactic acid; Membrane Transport Proteins - genetics; Membrane Transport Proteins - metabolism; neoplasm cells; neoplasms; Neoplasms - metabolism; Neoplasms - pathology; Original Research; pH homeostasis; Proteasome Endopeptidase Complex - metabolism; secretion; Time Factors; tissues; transcriptomics; transporters; Warburg effect; Cell proliferation; Fenton reaction; pH homeostasis; Cancer; Warburg effect

It has been observed that both cancer tissue cells and normal proliferating cells (NPCs) have the Warburg effect. Our goal here is to demonstrate that they do this for different reasons. To accomplish this, we have analyzed the transcriptomic data of over 7000 cancer and control tissues of 14 cancer...