Three-dimensional bioprinting collagen/silk fibroin scaffold combined with neural stem cells promotes nerve regeneration after spinal cord injury

• Published in: Neural regeneration research Vol. 15; no. 5; pp. 959 - 968
• Main Authors: Jiang, Ji-Peng, Liu, Xiao-Yin, Zhao, Fei, Zhu, Xiang, Li, Xiao-Yin, Niu, Xue-Gang, Yao, Zi-Tong, Dai, Chen, Xu, Hui-You, Ma, Ke, Chen, Xu-Yi, Zhang, Sai
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.05.2020; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury and Neuroscience, Center for Neurology and Neurosurgery of Chinese People's Armed Police Force(PAP)Medical Center, Tianjin, China%Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury and Neuroscience, Center for Neurology and Neurosurgery of Chinese People's Armed Police Force(PAP)Medical Center, Tianjin, China; Tianjin Medical University, Tianjin, China%Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury and Neuroscience, Center for Neurology and Neurosurgery of Chinese People's Armed Police Force(PAP)Medical Center, Tianjin, China%Department of Neurology, Luoyang First Hospital of Traditional Chinese Medicine, Luoyang, Henan Province, China%Department of Neurosurgery, Fourth Central Hospital of Tianjin, Tianjin, China; Department of Thoracic Surgery, General Hospital of People's Liberation Army(PLA), Beijing, China; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: 3d bioprinting; collagen; diffusion tensor imaging; functional recovery; magnetic resonance imaging; nerve regeneration; neural regeneration; neural stem cell; scaffold; silk fibroin; spinal cord injury; Collagen; Fourier transforms; Laboratory animals; Mechanical properties; Science; Sediments; Spinal cord injuries; Stem cells; Surgery; Transplants & implants; China; Germany; Beijing China; United States > US; spinal cord injury; magnetic resonance imaging; neural stem cell; neural regeneration; scaffold; collagen; diffusion tensor imaging; 3D bioprinting; nerve regeneration; functional recovery; silk fibroin

Many studies have shown that bio-scaffolds have important value for promoting axonal regeneration of injured spinal cord. Indeed, cell transplantation and bio-scaffold implantation are considered to be effective methods for neural regeneration. This study was designed to fabricate a type of three-di...