Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue

• Published in: Acta neuropathologica communications Vol. 5; no. 1; pp. 41 - 12
• Main Authors: Kaufman, Sarah K., Thomas, Talitha L., Del Tredici, Kelly, Braak, Heiko, Diamond, Marc I.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.06.2017; BioMed Central; BMC
• Subjects: Aging - metabolism; Aging - pathology; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Animals; Biopsy; Biosensing Techniques; Biosensors; Brain; Brain - metabolism; Brain - pathology; Cell Line; Disease; Disease Models, Animal; Disease Progression; Female; Fixatives; Flow Cytometry; Formaldehyde; Health aspects; Immunohistochemistry; Male; Methodology; Methods; Mice, Transgenic; Neuropathology; Paraffin Embedding; Pathology; Polyethylene glycol; Prions; Protein Aggregation, Pathological - metabolism; Protein Aggregation, Pathological - pathology; Protein research; Proteins; Rodents; Tau proteins; tau Proteins - genetics; tau Proteins - metabolism; Tissue engineering; Tissue Fixation; Transgenic animals

Tauopathies such as Alzheimer's disease (AD) feature progressive intraneuronal deposition of aggregated tau protein. The cause is unknown, but in experimental systems trans-cellular propagation of tau pathology resembles prion pathogenesis. Tau aggregate inoculation into mice produces transmiss...