Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy - Shen, Tong; Cai, Ling-Dong; Liu, Yu-Hong; Li, Shi; Gan, Wen-Juan; Li, Xiu-Ming; Wang, Jing-Ru; Guo, Peng-Da; Zhou, Qun; Lu, Xing-Xing; Sun, Li-Na; Li, Jian-Ming (Journal of hematology and oncology, 2018)
Keywords: Acetylation; Animals; Autophagy; Autophagy - physiology; Breast cancer; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Development and progression; Enzymes; Epigenesis, Genetic; Epithelial mesenchymal transition; Gene expression; Genetic aspects; Hematology; Heterografts; Histone H4; Homeostasis; Humans; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Kinases; Lung cancer; Lung Neoplasms - metabolism; Lung Neoplasms - secondary; Lysine; Mass spectroscopy; Mesenchyme; Metastases; Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Oncology; Phagocytosis; Physiological aspects; Polymerase chain reaction; Pore size; Post-translation; Proteasomes; Proteins; Rapamycin; SIRT1 protein; Sirtuin 1 - metabolism; Transcription Factors - metabolism; Transmission electron microscopy; Trehalose; Tumorigenesis; Ubiquitin; Ubiquitin-conjugating E2 enzyme; Ubiquitin-Conjugating Enzymes - metabolism; Ubiquitin-proteasome system; Ubiquitination; Veins & arteries; Western blotting; Xenografts; China; Epithelial mesenchymal transition; Metastasis; Autophagy; Colorectal cancer; Ubiquitin-conjugating E2 enzyme