empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics

• Published in: Diabetologia Vol. 53; no. 1; pp. 144 - 152
• Main Authors: Tura, A, Sbrignadello, S, Succurro, E, Groop, L, Sesti, G, Pacini, G
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 2010; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: Adult; Area Under Curve; Biological and medical sciences; blood; Blood Glucose; Blood Glucose - drug effects; Blood Glucose - metabolism; Body Mass Index; Clinical Medicine; Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - blood; Diabetes. Impaired glucose tolerance; drug effects; Endocrine pancreas. Apud cells (diseases); Endocrinology and Diabetes; Endocrinopathies; Endokrinologi och diabetes; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Glucose; Glucose Clamp Technique; Glucose Clamp Technique - methods; Glucose Intolerance; Glucose Intolerance - blood; Glucose tolerance; Glucose Tolerance Test; Glucose Tolerance Test - methods; Human Physiology; Humans; Hyperinsulinism; Hyperinsulinism - blood; Hyperparathyroidism; Hyperparathyroidism - blood; Hyperparathyroidism - surgery; Insulin; Insulin - pharmacology; Insulin action; Insulin resistance; Internal Medicine; intravenous glucose tolerance test; Kidney Diseases; Kidney Diseases - blood; Klinisk medicin; Mathematical models; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; methods; Middle Aged; Models, Biological; One hour; One hour intravenous glucose tolerance test; pharmacology; Regression Analysis; Reproducibility of Results; surgery; Glucose tolerance; One hour intravenous glucose tolerance test; Insulin resistance; Insulin action; Endocrinopathy; Human; Pancreatic hormone; Diabetes mellitus; Tolerance; Metabolic diseases; Glucose tolerance test; Glucose; Insulin; Target tissue resistance; Sensitivity; Models

Aims/hypothesis Minimal model analysis for insulin sensitivity has been validated against the glucose clamp and is an accepted method for estimating insulin sensitivity from IVGTT. However minimal model analysis requires a 3 h test and relevant expertise to run the mathematical model. The aim of thi...