Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1+ regulatory B cell expansion

• Published in: Journal for immunotherapy of cancer Vol. 6; no. 1; pp. 145 - 15
• Main Authors: Ye, Linsen, Zhang, Qi, Cheng, Yusheng, Chen, Xiaolong, Wang, Guoying, Shi, Mengchen, Zhang, Tong, Cao, Yingjiao, Pan, Hang, Zhang, Liting, Wang, Genshu, Deng, Yinan, Yang, Yang, Chen, Guihua
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.12.2018; BMJ Publishing Group LTD; BioMed Central; BMJ Publishing Group
• Subjects: Autoimmune diseases; Automation; B cells; Cancer; Cellular signal transduction; Control; Cytokines; Gene expression; Genetic aspects; Hepatoma; Liver cancer; Lymphocytes; Microscopy; Monoclonal antibodies; Patients; Proteins

Regulatory B (Breg) cells represent one of the B cell subsets that infiltrate solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, the phenotype, function and clinical relevance of Breg cells in human hepatocellular carcinoma (HCC) are presently unknown. Flow c...