Mechanotransduction in primary human osteoarthritic chondrocytes is mediated by metabolism of energy, lipids, and amino acids

• Published in: Journal of biomechanics Vol. 48; no. 16; pp. 4253 - 4261
• Main Authors: Zignego, Donald L, Hilmer, Jonathan K, June, Ronald K
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 16.12.2015; Elsevier Limited
• Subjects: Age; Aged; Aged, 80 and over; Amino Acids - metabolism; Arthritis; Biocompatibility; Biomedical materials; Cartilage, Articular - metabolism; Cells, Cultured; Chondrocyte biology; Chondrocytes - physiology; Compressing; Dynamics; Energy Metabolism; Funding; Human; Humans; Hypotheses; Kinases; Lipid Metabolism; Loads (forces); Mechanotransduction; Mechanotransduction, Cellular; Metabolism; Metabolites; Metabolomics; Middle Aged; Osteoarthritis; Osteoarthritis, Hip - metabolism; Osteoarthritis, Hip - pathology; Patients; Phosphorylation; Physical Medicine and Rehabilitation; Physiology; Proteins; Signal transduction; Studies; Systems biology; Metabolomics; Mechanotransduction; Systems biology; Osteoarthritis; Chondrocyte biology

Abstract Chondrocytes are the sole cell type found in articular cartilage and are repeatedly subjected to mechanical loading in vivo . We hypothesized that physiological dynamic compression results in changes in energy metabolism to produce proteins for maintenance of the pericellular and extracellu...