Increased circulating sclerostin levels in end-stage renal disease predict biopsy-verified vascular medial calcification and coronary artery calcification

• Published in: Kidney international Vol. 88; no. 6; pp. 1356 - 1364
• Main Authors: Qureshi, Abdul Rashid, Olauson, Hannes, Witasp, Anna, Haarhaus, Mathias, Brandenburg, Vincent, Wernerson, Annika, Lindholm, Bengt, Söderberg, Magnus, Wennberg, Lars, Nordfors, Louise, Ripsweden, Jonaz, Barany, Peter, Stenvinkel, Peter
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2015; Elsevier Limited
• Subjects: end-stage renal disease; inflammation; Medicin och hälsovetenskap; mineral-bone disease; sclerostin; vascular calcification; end-stage renal disease; inflammation; mineral-bone disease; vascular calcification; sclerostin

Sclerostin, an osteocyte-derived inhibitor of bone formation, is linked to mineral bone disorder. In order to validate its potential as a predictor of vascular calcification, we explored associations of circulating sclerostin with measures of calcification in 89 epigastric artery biopsies from patie...