Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells

• Published in: Journal of experimental & clinical cancer research Vol. 38; no. 1; pp. 402 - 16
• Main Authors: Chen, Yibing, Mi, Yanjun, Zhang, Xiaofei, Ma, Qian, Song, Yucen, Zhang, Liwei, Wang, Dandan, Xing, Jinliang, Hou, Benxin, Li, Haolong, Jin, Huan, Du, Wei, Zou, Zhengzhi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.09.2019; BioMed Central; BMC
• Subjects: Activating Transcription Factor 4 - metabolism; Animals; Apoptosis; Artemisinins - pharmacology; Biochemistry; Biomarkers; Cancer; Cancer treatment; Care and treatment; Cell death; Cell Line, Tumor; Cell proliferation; Cell Survival - drug effects; Dihydroartemisinin; Disease Models, Animal; eIF-2 Kinase - metabolism; Endoplasmic reticulum; Endoplasmic reticulum stress; Ferroptosis; Ferroptosis - drug effects; Gene Expression; Genetic aspects; Glioma; Glioma - metabolism; Gliomas; GPX4; Heat shock proteins; Heat-Shock Proteins - metabolism; HSPA5; Humans; Kinases; Lipid peroxidation; Lipids; Mice; Novels; Peroxidase; Protein kinases; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects; Unfolded Protein Response - drug effects; Dihydroartemisinin; Ferroptosis; GPX4; Glioma; HSPA5; Endoplasmic reticulum stress

Dihydroartemisinin (DHA) has been shown to exert anticancer activity through iron-dependent reactive oxygen species (ROS) generation, which is similar to ferroptosis, a novel form of cell death. However, whether DHA causes ferroptosis in glioma cells and the potential regulatory mechanisms remain un...