Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells - Chen, Yibing; Mi, Yanjun; Zhang, Xiaofei; Ma, Qian; Song, Yucen; Zhang, Liwei; Wang, Dandan; Xing, Jinliang; Hou, Benxin; Li, Haolong; Jin, Huan; Du, Wei; et al. (Journal of experimental & clinical cancer research, 2019)
Keywords: Activating Transcription Factor 4 - metabolism; Animals; Apoptosis; Artemisinins - pharmacology; Biochemistry; Biomarkers; Cancer; Cancer treatment; Care and treatment; Cell death; Cell Line, Tumor; Cell proliferation; Cell Survival - drug effects; Dihydroartemisinin; Disease Models, Animal; eIF-2 Kinase - metabolism; Endoplasmic reticulum; Endoplasmic reticulum stress; Ferroptosis; Ferroptosis - drug effects; Gene Expression; Genetic aspects; Glioma; Glioma - metabolism; Gliomas; GPX4; Heat shock proteins; Heat-Shock Proteins - metabolism; HSPA5; Humans; Kinases; Lipid peroxidation; Lipids; Mice; Novels; Peroxidase; Protein kinases; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects; Unfolded Protein Response - drug effects; Dihydroartemisinin; Ferroptosis; GPX4; Glioma; HSPA5; Endoplasmic reticulum stress