NGAL与妊娠相关疾病的研究进展

中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)作为脂质运载蛋白lipocalin家族的新成员,是一种脂肪细胞因子,亦是一种炎症因子。NGAL在机体中参与不同的生理、病理过程,涉及胚胎发育、细胞分化、细胞凋亡、肿瘤的发生及发展、炎症免疫反应、糖脂代谢及胰岛素抵抗等。妊娠期高血压疾病、妊娠期糖尿病(gestational diabetes mellitus,GDM)及早产等是常见的妊娠相关疾病,其发生、发展与机体的炎症反应、糖脂代谢及胰岛素抵抗关系密切,这些疾病严重影响妊娠结局和母婴的预后情况。NGAL的生物学功能...

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Bibliographic Details
Published in国际生殖健康/计划生育杂志 Vol. 37; no. 2; pp. 158 - 161
Main Author 尹晓茜;张艳红;霍琰
Format Journal Article
LanguageChinese
Published 075000 张家口,河北北方学院研究生院 2018
河北省人民医院产科%河北医科大学研究生院
Subjects
中性粒细胞明胶酶相关脂质运载蛋白;脂肪因子类;炎症介导素类;胰岛素抗药性;妊娠并发症
脂肪因子类
胰岛素抗药性
Inflammation mediators
中性粒细胞明胶酶相关脂质运载蛋白
炎症介导素类
Pregnancy complications
Insulin resistance
Neutrophil gelatinase-associated lipocalin
Adipokines
妊娠并发症
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ISSN1674-1889

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Summary:中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)作为脂质运载蛋白lipocalin家族的新成员,是一种脂肪细胞因子,亦是一种炎症因子。NGAL在机体中参与不同的生理、病理过程,涉及胚胎发育、细胞分化、细胞凋亡、肿瘤的发生及发展、炎症免疫反应、糖脂代谢及胰岛素抵抗等。妊娠期高血压疾病、妊娠期糖尿病(gestational diabetes mellitus,GDM)及早产等是常见的妊娠相关疾病,其发生、发展与机体的炎症反应、糖脂代谢及胰岛素抵抗关系密切,这些疾病严重影响妊娠结局和母婴的预后情况。NGAL的生物学功能使其在妊娠期高血压疾病、GDM及早产等妊娠相关疾病中亦发挥重要作用。本文对NGAL及其与妊娠相关疾病的研究进展进行综述。
Bibliography:Neutrophil gelatinase-associated lipocalin;Adipokines;Inflammation mediators;Insulin resistance;Pregnancy complications
Neutrophil gelatinase-associated lipocalin(NGAL),a new member of lipocalin family,is a fatty cytokine or an inflammatory factor.NGAL participates in various physiological and pathological processes,such as embryonic development,cell differentiation,apoptosis,tumor occurrence and development,inflammatory immune response,glucose and lipid metabolism,and insulin resistance.Hypertensive disorders complicating pregnancy,gestational diabetes mellitus(GDM)and premature birth,three kinds of common pregnancy-related diseases,are closely related to the inflammatory reaction,glucose and lipid metabolism,and insulin resistance.These diseases seriously affect the outcome of pregnancy and the prognosis of mothers and infants.It was reported that NGAL also played an important role in pregnancy-related diseases such as hypertensive disorders complicating pregnancy,GDM and premature birth.This article will re
ISSN:1674-1889