Gamma-glutamyl transpeptidase (γ-GTP) has an ambivalent association with hypertension and atherosclerosis among elderly Japanese men: a cross-sectional study

Background: Even though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process of endothelial repair. To clarify the association of endothelial repair with hypertension, a cross-sectional study was conducted. Methods: We conduct...

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Published inEnvironmental Health and Preventive Medicine Vol. 24; no. 1; pp. 69 - 7
Main Authors Shimizu, Yuji, Kawashiri, Shin-Ya, Kiyoura, Kairi, Nobusue, Kenichi, Yamanashi, Hirotomo, Nagata, Yasuhiro, Maeda, Takahiro
Format Journal Article
LanguageEnglish
Published England BioMed Central 30.11.2019
Komiyama Printing Co., Ltd
Komiyama Printing Co. Ltd
Subjects
Age
Aged
Alcohol
Antigens, CD34 - analysis
Arteriosclerosis
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - enzymology
Atherosclerosis - epidemiology
Atherosclerosis - pathology
Automation
Biomarkers - blood
Blood pressure
Body mass index
Bone marrow
CD34
CD34 antigen
Cross-Sectional Studies
Endothelial cells
Endothelial Cells - chemistry
Endothelial Cells - pathology
Endothelium
Environmental health
gamma-Glutamyltransferase - blood
Guanosine triphosphate
Humans
Hypertension
Hypertension - blood
Hypertension - enzymology
Hypertension - epidemiology
Hypertension - pathology
Japan - epidemiology
Laboratories
Male
Middle Aged
Odds Ratio
Older people
Oxidative stress
Population
Population studies
Repair
Risk factors
Software
γ-Glutamyltransferase
γ-GTP
Japan
Hypertension
CD34
Atherosclerosis
γ-GTP
Online AccessGet full text
ISSN1342-078X
1347-4715
1347-4715
DOI10.1186/s12199-019-0828-2

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Abstract Background: Even though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process of endothelial repair. To clarify the association of endothelial repair with hypertension, a cross-sectional study was conducted. Methods: We conducted a cross-sectional study of 562 elderly Japanese men aged 60-69. As gamma-glutamyl transpeptidase (γ-GTP) could act as a marker of oxidative stress that injures endothelial cell and higher levels of CD34-positive cell indicate a higher activity of endothelial repair, we therefore performed a CD34-positive level specific analysis of γ-GTP on atherosclerosis and hypertension. Results: In the present study population, hypertension was independently and positively associated with atherosclerosis (multivariable odds ratio (OR) = 2.09 (1.30, 3.35)). Among participants with high CD34-positive cells, γ-GTP showed significant and positive association with atherosclerosis (OR of the log-transformed value of γ-GTP (OR) = 2.26 (1.32, 3.86)) but not with hypertension (OR = 0.77 (0.51, 1.17)). Among participants with low CD34-positive cells, even γ-GTP showed no significant association with atherosclerosis (OR = 0.92 (0.51, 1.68)), but was significantly and positively associated with hypertension (OR = 1.99 (1.27, 3.12)). Conclusions: γ-GTP revealed to have ambivalent association with hypertension and atherosclerosis. Active endothelial repair that is associated with atherosclerosis might have beneficial association with hypertension.
AbstractList Background Even though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process of endothelial repair. To clarify the association of endothelial repair with hypertension, a cross-sectional study was conducted. Methods We conducted a cross-sectional study of 562 elderly Japanese men aged 60–69. As gamma-glutamyl transpeptidase (γ-GTP) could act as a marker of oxidative stress that injures endothelial cell and higher levels of CD34-positive cell indicate a higher activity of endothelial repair, we therefore performed a CD34-positive level specific analysis of γ-GTP on atherosclerosis and hypertension. Results In the present study population, hypertension was independently and positively associated with atherosclerosis (multivariable odds ratio (OR) = 2.09 (1.30, 3.35)). Among participants with high CD34-positive cells, γ-GTP showed significant and positive association with atherosclerosis (OR of the log-transformed value of γ-GTP (OR) = 2.26 (1.32, 3.86)) but not with hypertension (OR = 0.77 (0.51, 1.17)). Among participants with low CD34-positive cells, even γ-GTP showed no significant association with atherosclerosis (OR = 0.92 (0.51, 1.68)), but was significantly and positively associated with hypertension (OR = 1.99 (1.27, 3.12)). Conclusions γ-GTP revealed to have ambivalent association with hypertension and atherosclerosis. Active endothelial repair that is associated with atherosclerosis might have beneficial association with hypertension.
Even though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process of endothelial repair. To clarify the association of endothelial repair with hypertension, a cross-sectional study was conducted. We conducted a cross-sectional study of 562 elderly Japanese men aged 60-69. As gamma-glutamyl transpeptidase (γ-GTP) could act as a marker of oxidative stress that injures endothelial cell and higher levels of CD34-positive cell indicate a higher activity of endothelial repair, we therefore performed a CD34-positive level specific analysis of γ-GTP on atherosclerosis and hypertension. In the present study population, hypertension was independently and positively associated with atherosclerosis (multivariable odds ratio (OR) = 2.09 (1.30, 3.35)). Among participants with high CD34-positive cells, γ-GTP showed significant and positive association with atherosclerosis (OR of the log-transformed value of γ-GTP (OR) = 2.26 (1.32, 3.86)) but not with hypertension (OR = 0.77 (0.51, 1.17)). Among participants with low CD34-positive cells, even γ-GTP showed no significant association with atherosclerosis (OR = 0.92 (0.51, 1.68)), but was significantly and positively associated with hypertension (OR = 1.99 (1.27, 3.12)). γ-GTP revealed to have ambivalent association with hypertension and atherosclerosis. Active endothelial repair that is associated with atherosclerosis might have beneficial association with hypertension.
Even though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process of endothelial repair. To clarify the association of endothelial repair with hypertension, a cross-sectional study was conducted.BACKGROUNDEven though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process of endothelial repair. To clarify the association of endothelial repair with hypertension, a cross-sectional study was conducted.We conducted a cross-sectional study of 562 elderly Japanese men aged 60-69. As gamma-glutamyl transpeptidase (γ-GTP) could act as a marker of oxidative stress that injures endothelial cell and higher levels of CD34-positive cell indicate a higher activity of endothelial repair, we therefore performed a CD34-positive level specific analysis of γ-GTP on atherosclerosis and hypertension.METHODSWe conducted a cross-sectional study of 562 elderly Japanese men aged 60-69. As gamma-glutamyl transpeptidase (γ-GTP) could act as a marker of oxidative stress that injures endothelial cell and higher levels of CD34-positive cell indicate a higher activity of endothelial repair, we therefore performed a CD34-positive level specific analysis of γ-GTP on atherosclerosis and hypertension.In the present study population, hypertension was independently and positively associated with atherosclerosis (multivariable odds ratio (OR) = 2.09 (1.30, 3.35)). Among participants with high CD34-positive cells, γ-GTP showed significant and positive association with atherosclerosis (OR of the log-transformed value of γ-GTP (OR) = 2.26 (1.32, 3.86)) but not with hypertension (OR = 0.77 (0.51, 1.17)). Among participants with low CD34-positive cells, even γ-GTP showed no significant association with atherosclerosis (OR = 0.92 (0.51, 1.68)), but was significantly and positively associated with hypertension (OR = 1.99 (1.27, 3.12)).RESULTSIn the present study population, hypertension was independently and positively associated with atherosclerosis (multivariable odds ratio (OR) = 2.09 (1.30, 3.35)). Among participants with high CD34-positive cells, γ-GTP showed significant and positive association with atherosclerosis (OR of the log-transformed value of γ-GTP (OR) = 2.26 (1.32, 3.86)) but not with hypertension (OR = 0.77 (0.51, 1.17)). Among participants with low CD34-positive cells, even γ-GTP showed no significant association with atherosclerosis (OR = 0.92 (0.51, 1.68)), but was significantly and positively associated with hypertension (OR = 1.99 (1.27, 3.12)).γ-GTP revealed to have ambivalent association with hypertension and atherosclerosis. Active endothelial repair that is associated with atherosclerosis might have beneficial association with hypertension.CONCLUSIONSγ-GTP revealed to have ambivalent association with hypertension and atherosclerosis. Active endothelial repair that is associated with atherosclerosis might have beneficial association with hypertension.
Abstract Background Even though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process of endothelial repair. To clarify the association of endothelial repair with hypertension, a cross-sectional study was conducted. Methods We conducted a cross-sectional study of 562 elderly Japanese men aged 60–69. As gamma-glutamyl transpeptidase (γ-GTP) could act as a marker of oxidative stress that injures endothelial cell and higher levels of CD34-positive cell indicate a higher activity of endothelial repair, we therefore performed a CD34-positive level specific analysis of γ-GTP on atherosclerosis and hypertension. Results In the present study population, hypertension was independently and positively associated with atherosclerosis (multivariable odds ratio (OR) = 2.09 (1.30, 3.35)). Among participants with high CD34-positive cells, γ-GTP showed significant and positive association with atherosclerosis (OR of the log-transformed value of γ-GTP (OR) = 2.26 (1.32, 3.86)) but not with hypertension (OR = 0.77 (0.51, 1.17)). Among participants with low CD34-positive cells, even γ-GTP showed no significant association with atherosclerosis (OR = 0.92 (0.51, 1.68)), but was significantly and positively associated with hypertension (OR = 1.99 (1.27, 3.12)). Conclusions γ-GTP revealed to have ambivalent association with hypertension and atherosclerosis. Active endothelial repair that is associated with atherosclerosis might have beneficial association with hypertension.
ArticleNumber 69
Author Yamanashi Hirotomo
Nobusue Kenichi
Maeda Takahiro
Kiyoura Kairi
Shimizu Yuji
Kawashiri Shin-Ya
Nagata Yasuhiro
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Cites_doi 10.1089/scd.1.1996.5.213
10.1182/blood.V92.2.362
10.1186/s12199-017-0684-x
10.1007/s40292-017-0245-9
10.1007/s00394-017-1407-1
10.2119/molmed.2011.00043
10.1111/joim.12605
10.1007/s11883-017-0678-6
10.1111/ggi.13657
10.1515/CCLM.2006.149
10.1096/fj.06-6265fje
10.1016/j.atherosclerosis.2019.02.004
10.18632/oncotarget.17474
10.3109/00365513.2014.954141
10.1161/CIRCULATIONAHA.107.714691
10.1016/j.atherosclerosis.2017.02.016
10.18632/aging.101768
10.2337/diacare.15.10.1290
10.1186/s12199-018-0705-4
10.1161/CIRCULATIONAHA.106.621714
10.1038/7434
10.1182/asheducation-2005.1.528
10.1016/j.amjhyper.2006.05.010
10.1177/0271678X17696322
10.1097/BLO.0b013e318159a9b8
10.1089/ars.2014.5928
10.1016/S0092-8674(00)00025-8
10.1016/j.mad.2010.10.002
10.1161/STROKEAHA.109.569061
10.1186/s40101-017-0143-9
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Keywords Hypertension
CD34
Atherosclerosis
γ-GTP
Language English
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References Yi-Chu Liao (828_CR31) 2011; 17
Tomono Takahashi (828_CR9) 1999; 5
Y Shimizu (828_CR25) 2017; 22
M. Tesauro (828_CR27) 2017; 281
Shi Shu (828_CR30) 2017; 37
H Uçar (828_CR3) 2015; 75
D. ROBERT SUTHERLAND (828_CR19) 1996; 5
828_CR32
Qun Shi (828_CR10) 1998; 92
Yuji Shimizu (828_CR33) 2010; 41
Y Shimizu (828_CR23) 2019; 11
828_CR18
828_CR5
828_CR7
Jack M. Guralnik (828_CR11) 2005; 2005
Yuji Shimizu (828_CR1) 2017; 259
Nobuyuki Takakura (828_CR29) 2000; 102
T YANASE (828_CR21) 2006; 19
K Garvin (828_CR13) 2007; 465
Y Shimizu (828_CR24) 2018; 23
Rosa Maria Bruno (828_CR28) 2018; 25
A.-Ra Cho (828_CR2) 2017; 57
Stefan I. Liochev (828_CR6) 2015; 23
Konstantinos Stellos (828_CR14) 2008; 117
828_CR20
R. Kawamori (828_CR22) 1992; 15
Karin Daub (828_CR15) 2006; 20
S.K. Brusnahan (828_CR12) 2010; 131
Yuji Shimizu (828_CR17) 2019; 19
AJ Kattoor (828_CR4) 2017; 19
Y Shimizu (828_CR26) 2017; 36
Teruo Inoue (828_CR8) 2007; 115
Y Shimizu (828_CR16) 2019; 283
References_xml – volume: 5
  start-page: 213
  issue: 3
  year: 1996
  ident: 828_CR19
  publication-title: Journal of Hematotherapy
  doi: 10.1089/scd.1.1996.5.213
– volume: 92
  start-page: 362
  issue: 2
  year: 1998
  ident: 828_CR10
  publication-title: Blood
  doi: 10.1182/blood.V92.2.362
– ident: 828_CR5
– volume: 22
  start-page: 77
  issue: 1
  year: 2017
  ident: 828_CR25
  publication-title: Environ Health Prev Med.
  doi: 10.1186/s12199-017-0684-x
– volume: 25
  start-page: 35
  issue: 1
  year: 2018
  ident: 828_CR28
  publication-title: High Blood Pressure & Cardiovascular Prevention
  doi: 10.1007/s40292-017-0245-9
– volume: 57
  start-page: 1237
  issue: 3
  year: 2017
  ident: 828_CR2
  publication-title: European Journal of Nutrition
  doi: 10.1007/s00394-017-1407-1
– volume: 17
  start-page: 1065
  issue: 9-10
  year: 2011
  ident: 828_CR31
  publication-title: Molecular Medicine
  doi: 10.2119/molmed.2011.00043
– volume: 281
  start-page: 471
  issue: 5
  year: 2017
  ident: 828_CR27
  publication-title: Journal of Internal Medicine
  doi: 10.1111/joim.12605
– volume: 19
  start-page: 42
  issue: 11
  year: 2017
  ident: 828_CR4
  publication-title: Curr Atheroscler Rep.
  doi: 10.1007/s11883-017-0678-6
– volume: 19
  start-page: 557
  issue: 6
  year: 2019
  ident: 828_CR17
  publication-title: Geriatrics & Gerontology International
  doi: 10.1111/ggi.13657
– ident: 828_CR20
  doi: 10.1515/CCLM.2006.149
– volume: 20
  start-page: 2559
  issue: 14
  year: 2006
  ident: 828_CR15
  publication-title: The FASEB Journal
  doi: 10.1096/fj.06-6265fje
– volume: 283
  start-page: 85
  year: 2019
  ident: 828_CR16
  publication-title: Atherosclerosis.
  doi: 10.1016/j.atherosclerosis.2019.02.004
– ident: 828_CR7
– ident: 828_CR32
  doi: 10.18632/oncotarget.17474
– volume: 75
  start-page: 7
  issue: 1
  year: 2015
  ident: 828_CR3
  publication-title: Scand J Clin Lab Invest
  doi: 10.3109/00365513.2014.954141
– volume: 117
  start-page: 206
  issue: 2
  year: 2008
  ident: 828_CR14
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.107.714691
– volume: 259
  start-page: 26
  year: 2017
  ident: 828_CR1
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2017.02.016
– volume: 11
  start-page: 663
  issue: 2
  year: 2019
  ident: 828_CR23
  publication-title: Aging (Albany NY).
  doi: 10.18632/aging.101768
– volume: 15
  start-page: 1290
  issue: 10
  year: 1992
  ident: 828_CR22
  publication-title: Diabetes Care
  doi: 10.2337/diacare.15.10.1290
– volume: 23
  start-page: 16
  issue: 1
  year: 2018
  ident: 828_CR24
  publication-title: Environ Health Prev Med.
  doi: 10.1186/s12199-018-0705-4
– volume: 115
  start-page: 553
  issue: 5
  year: 2007
  ident: 828_CR8
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.621714
– volume: 5
  start-page: 434
  issue: 4
  year: 1999
  ident: 828_CR9
  publication-title: Nature Medicine
  doi: 10.1038/7434
– volume: 2005
  start-page: 528
  issue: 1
  year: 2005
  ident: 828_CR11
  publication-title: Hematology
  doi: 10.1182/asheducation-2005.1.528
– volume: 19
  start-page: 1206
  issue: 12
  year: 2006
  ident: 828_CR21
  publication-title: American Journal of Hypertension
  doi: 10.1016/j.amjhyper.2006.05.010
– volume: 37
  start-page: 3401
  issue: 10
  year: 2017
  ident: 828_CR30
  publication-title: Journal of Cerebral Blood Flow & Metabolism
  doi: 10.1177/0271678X17696322
– volume: 465
  start-page: 202
  year: 2007
  ident: 828_CR13
  publication-title: Clin Orthop Relat Res.
  doi: 10.1097/BLO.0b013e318159a9b8
– volume: 23
  start-page: 187
  issue: 3
  year: 2015
  ident: 828_CR6
  publication-title: Antioxidants & Redox Signaling
  doi: 10.1089/ars.2014.5928
– volume: 102
  start-page: 199
  issue: 2
  year: 2000
  ident: 828_CR29
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)00025-8
– volume: 131
  start-page: 718
  issue: 11-12
  year: 2010
  ident: 828_CR12
  publication-title: Mechanisms of Ageing and Development
  doi: 10.1016/j.mad.2010.10.002
– ident: 828_CR18
– volume: 41
  start-page: 385
  issue: 2
  year: 2010
  ident: 828_CR33
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.109.569061
– volume: 36
  start-page: 26
  issue: 1
  year: 2017
  ident: 828_CR26
  publication-title: J Physiol Anthropol.
  doi: 10.1186/s40101-017-0143-9
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Snippet Background: Even though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process of...
Even though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process of endothelial...
Background Even though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process of...
Abstract Background Even though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process...
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StartPage 69
SubjectTerms Age
Aged
Alcohol
Antigens, CD34 - analysis
Arteriosclerosis
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - enzymology
Atherosclerosis - epidemiology
Atherosclerosis - pathology
Automation
Biomarkers - blood
Blood pressure
Body mass index
Bone marrow
CD34
CD34 antigen
Cross-Sectional Studies
Endothelial cells
Endothelial Cells - chemistry
Endothelial Cells - pathology
Endothelium
Environmental health
gamma-Glutamyltransferase - blood
Guanosine triphosphate
Humans
Hypertension
Hypertension - blood
Hypertension - enzymology
Hypertension - epidemiology
Hypertension - pathology
Japan - epidemiology
Laboratories
Male
Middle Aged
Odds Ratio
Older people
Oxidative stress
Population
Population studies
Repair
Risk factors
Software
γ-Glutamyltransferase
γ-GTP
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Title Gamma-glutamyl transpeptidase (γ-GTP) has an ambivalent association with hypertension and atherosclerosis among elderly Japanese men: a cross-sectional study
URI https://cir.nii.ac.jp/crid/1570572702864781824
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