Evidence for the Involvement of Apoptosis-Inducing Factor–Mediated Caspase-Independent Neuronal Death in Alzheimer Disease

• Published in: The American journal of pathology Vol. 176; no. 5; pp. 2209 - 2218
• Main Authors: Yu, Wenfeng, Mechawar, Naguib, Krantic, Slavica, Quirion, Rémi
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.05.2010; American Society for Investigative Pathology
• Subjects: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Alzheimer Disease - pathology; Apoptosis Inducing Factor - metabolism; Biological and medical sciences; Brain - metabolism; Brain - pathology; Caspases - metabolism; Cell Nucleus - metabolism; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Models, Biological; Neurology; Neurons - metabolism; Neurons - pathology; Organic mental disorders. Neuropsychology; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Protein Structure, Tertiary; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Regular; Subcellular Fractions - metabolism; Nervous system diseases; Enzyme; Alzheimer disease; Cysteine endopeptidases; Caspase; Cerebral disorder; Peptidases; Anatomic pathology; Neuron; Cell death; Central nervous system disease; Hydrolases; Degenerative disease; Apoptosis inducing factor
• ISSN: 0002-9440; 1525-2191; 1525-2191
• DOI: 10.2353/ajpath.2010.090496

Accumulating evidence suggests the involvement of caspase-dependent and -independent mechanisms in neuronal cell death in Alzheimer disease (AD). The apoptosis-inducing factor (AIF) is a mitochondrial oxido-reductase originally characterized as a mediator of caspase-independent programmed cell death...