Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging - Ahmed, Zeshan; Sheng, Hong; Xu, Ya-fei; Lin, Wen-Lang; Innes, Amy E.; Gass, Jennifer; Yu, Xin; Hou, Harold; Chiba, Shuichi; Yamanouchi, Keitaro; Leissring, Malcolm; Petrucelli, Leonard; et al. (The American journal of pathology, 2010)
Keywords: Aging - physiology; Animals; Biological and medical sciences; Brain - cytology; Brain - metabolism; Brain - pathology; Errors of metabolism; Humans; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; Investigative techniques, diagnostic techniques (general aspects); Lipids (lysosomal enzyme disorders, storage diseases); Medical sciences; Metabolic diseases; Mice; Mice, Knockout; Neuronal Ceroid-Lipofuscinoses - genetics; Neuronal Ceroid-Lipofuscinoses - metabolism; Neuronal Ceroid-Lipofuscinoses - pathology; Neurons - cytology; Neurons - metabolism; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Progranulins; Regular; Ubiquitin - metabolism; Ubiquitination; Progranulin; Ageing; Metabolic diseases; Enzymopathy; Lipofuscinosis; Genetic disease; Anatomic pathology; Ubiquitination; Animal; Knockout mouse; Pigments; Lipoidosis; Age