Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging
Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its function in the central nervous system is unknown. Roles in development, sexual differentiation, and long-term neuronal survival have been suggested. Mutations in the GRN gene resulting in partial loss of the...
Saved in:
| Published in | The American journal of pathology Vol. 177; no. 1; pp. 311 - 324 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Bethesda, MD
Elsevier Inc
01.07.2010
American Society for Investigative Pathology |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its function in the central nervous system is unknown. Roles in development, sexual differentiation, and long-term neuronal survival have been suggested. Mutations in the
GRN
gene resulting in partial loss of the encoded PGRN protein cause frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions. We sought to understand the neuropathological consequences of loss of PGRN function throughout the lifespan of
GRN
-deficient (
−/+ and
−/−) mice. An aged series of
GRN
-deficient and wild-type mice were compared by histology, immunohistochemistry, and electron microscopy. Although
GRN
-deficient mice were viable,
GRN
−/− mice were produced at lower than predicted frequency. Neuropathologically,
GRN
−/+ were indistinguishable from controls; however,
GRN
−/− mice developed age-associated, abnormal intraneuronal ubiquitin-positive autofluorescent lipofuscin. Lipofuscin was noted in aged
GRN
+/+ mice at levels comparable with those of young
GRN
−/− mice.
GRN
−/− mice developed microgliosis, astrogliosis, and tissue vacuolation, with focal neuronal loss and severe gliosis apparent in the oldest
GRN
−/− mice. Although no overt frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions type- or TAR DNA binding protein-43-positive lesions were observed, robust lipofuscinosis and ubiquitination in
GRN
−/− mice is strikingly similar to changes associated with aging and cellular decline in humans and animal models. Our data suggests that PGRN plays a key role in maintaining neuronal function during aging and supports the notion that PGRN is a trophic factor essential for long-term neuronal survival. |
|---|---|
| AbstractList | Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its function in the central nervous system is unknown. Roles in development, sexual differentiation, and long-term neuronal survival have been suggested. Mutations in the
GRN
gene resulting in partial loss of the encoded PGRN protein cause frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions. We sought to understand the neuropathological consequences of loss of PGRN function throughout the lifespan of
GRN
-deficient (
−/+ and
−/−) mice. An aged series of
GRN
-deficient and wild-type mice were compared by histology, immunohistochemistry, and electron microscopy. Although
GRN
-deficient mice were viable,
GRN
−/− mice were produced at lower than predicted frequency. Neuropathologically,
GRN
−/+ were indistinguishable from controls; however,
GRN
−/− mice developed age-associated, abnormal intraneuronal ubiquitin-positive autofluorescent lipofuscin. Lipofuscin was noted in aged
GRN
+/+ mice at levels comparable with those of young
GRN
−/− mice.
GRN
−/− mice developed microgliosis, astrogliosis, and tissue vacuolation, with focal neuronal loss and severe gliosis apparent in the oldest
GRN
−/− mice. Although no overt frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions type- or TAR DNA binding protein-43-positive lesions were observed, robust lipofuscinosis and ubiquitination in
GRN
−/− mice is strikingly similar to changes associated with aging and cellular decline in humans and animal models. Our data suggests that PGRN plays a key role in maintaining neuronal function during aging and supports the notion that PGRN is a trophic factor essential for long-term neuronal survival. Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its function in the central nervous system is unknown. Roles in development, sexual differentiation, and long-term neuronal survival have been suggested. Mutations in the GRN gene resulting in partial loss of the encoded PGRN protein cause frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions. We sought to understand the neuropathological consequences of loss of PGRN function throughout the lifespan of GRN -deficient ( −/+ and −/− ) mice. An aged series of GRN -deficient and wild-type mice were compared by histology, immunohistochemistry, and electron microscopy. Although GRN -deficient mice were viable, GRN −/− mice were produced at lower than predicted frequency. Neuropathologically, GRN −/+ were indistinguishable from controls; however, GRN −/− mice developed age-associated, abnormal intraneuronal ubiquitin-positive autofluorescent lipofuscin. Lipofuscin was noted in aged GRN +/+ mice at levels comparable with those of young GRN −/− mice. GRN −/− mice developed microgliosis, astrogliosis, and tissue vacuolation, with focal neuronal loss and severe gliosis apparent in the oldest GRN −/− mice. Although no overt frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions type- or TAR DNA binding protein-43-positive lesions were observed, robust lipofuscinosis and ubiquitination in GRN −/− mice is strikingly similar to changes associated with aging and cellular decline in humans and animal models. Our data suggests that PGRN plays a key role in maintaining neuronal function during aging and supports the notion that PGRN is a trophic factor essential for long-term neuronal survival. Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its function in the central nervous system is unknown. Roles in development, sexual differentiation, and long-term neuronal survival have been suggested. Mutations in the GRN gene resulting in partial loss of the encoded PGRN protein cause frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions. We sought to understand the neuropathological consequences of loss of PGRN function throughout the lifespan of GRN-deficient ((-/+) and (-/-)) mice. An aged series of GRN-deficient and wild-type mice were compared by histology, immunohistochemistry, and electron microscopy. Although GRN-deficient mice were viable, GRN(-/-) mice were produced at lower than predicted frequency. Neuropathologically, GRN(-/+) were indistinguishable from controls; however, GRN(-/-) mice developed age-associated, abnormal intraneuronal ubiquitin-positive autofluorescent lipofuscin. Lipofuscin was noted in aged GRN(+/+) mice at levels comparable with those of young GRN(-/-) mice. GRN(-/-) mice developed microgliosis, astrogliosis, and tissue vacuolation, with focal neuronal loss and severe gliosis apparent in the oldest GRN(-/-) mice. Although no overt frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions type- or TAR DNA binding protein-43-positive lesions were observed, robust lipofuscinosis and ubiquitination in GRN(-/-) mice is strikingly similar to changes associated with aging and cellular decline in humans and animal models. Our data suggests that PGRN plays a key role in maintaining neuronal function during aging and supports the notion that PGRN is a trophic factor essential for long-term neuronal survival. Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its function in the central nervous system is unknown. Roles in development, sexual differentiation, and long-term neuronal survival have been suggested. Mutations in the GRN gene resulting in partial loss of the encoded PGRN protein cause frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions. We sought to understand the neuropathological consequences of loss of PGRN function throughout the lifespan of GRN-deficient ((-/+) and (-/-)) mice. An aged series of GRN-deficient and wild-type mice were compared by histology, immunohistochemistry, and electron microscopy. Although GRN-deficient mice were viable, GRN(-/-) mice were produced at lower than predicted frequency. Neuropathologically, GRN(-/+) were indistinguishable from controls; however, GRN(-/-) mice developed age-associated, abnormal intraneuronal ubiquitin-positive autofluorescent lipofuscin. Lipofuscin was noted in aged GRN(+/+) mice at levels comparable with those of young GRN(-/-) mice. GRN(-/-) mice developed microgliosis, astrogliosis, and tissue vacuolation, with focal neuronal loss and severe gliosis apparent in the oldest GRN(-/-) mice. Although no overt frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions type- or TAR DNA binding protein-43-positive lesions were observed, robust lipofuscinosis and ubiquitination in GRN(-/-) mice is strikingly similar to changes associated with aging and cellular decline in humans and animal models. Our data suggests that PGRN plays a key role in maintaining neuronal function during aging and supports the notion that PGRN is a trophic factor essential for long-term neuronal survival.Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its function in the central nervous system is unknown. Roles in development, sexual differentiation, and long-term neuronal survival have been suggested. Mutations in the GRN gene resulting in partial loss of the encoded PGRN protein cause frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions. We sought to understand the neuropathological consequences of loss of PGRN function throughout the lifespan of GRN-deficient ((-/+) and (-/-)) mice. An aged series of GRN-deficient and wild-type mice were compared by histology, immunohistochemistry, and electron microscopy. Although GRN-deficient mice were viable, GRN(-/-) mice were produced at lower than predicted frequency. Neuropathologically, GRN(-/+) were indistinguishable from controls; however, GRN(-/-) mice developed age-associated, abnormal intraneuronal ubiquitin-positive autofluorescent lipofuscin. Lipofuscin was noted in aged GRN(+/+) mice at levels comparable with those of young GRN(-/-) mice. GRN(-/-) mice developed microgliosis, astrogliosis, and tissue vacuolation, with focal neuronal loss and severe gliosis apparent in the oldest GRN(-/-) mice. Although no overt frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions type- or TAR DNA binding protein-43-positive lesions were observed, robust lipofuscinosis and ubiquitination in GRN(-/-) mice is strikingly similar to changes associated with aging and cellular decline in humans and animal models. Our data suggests that PGRN plays a key role in maintaining neuronal function during aging and supports the notion that PGRN is a trophic factor essential for long-term neuronal survival. Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its function in the central nervous system is unknown. Roles in development, sexual differentiation, and long-term neuronal survival have been suggested. Mutations in the GRN gene resulting in partial loss of the encoded PGRN protein cause frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions. We sought to understand the neuropathological consequences of loss of PGRN function throughout the lifespan of GRN -deficient (−/+ and−/− ) mice. An aged series of GRN -deficient and wild-type mice were compared by histology, immunohistochemistry, and electron microscopy. Although GRN -deficient mice were viable, GRN−/− mice were produced at lower than predicted frequency. Neuropathologically, GRN−/+ were indistinguishable from controls; however, GRN−/− mice developed age-associated, abnormal intraneuronal ubiquitin-positive autofluorescent lipofuscin. Lipofuscin was noted in aged GRN+/+ mice at levels comparable with those of young GRN−/− mice. GRN−/− mice developed microgliosis, astrogliosis, and tissue vacuolation, with focal neuronal loss and severe gliosis apparent in the oldest GRN−/− mice. Although no overt frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions type- or TAR DNA binding protein-43-positive lesions were observed, robust lipofuscinosis and ubiquitination in GRN−/− mice is strikingly similar to changes associated with aging and cellular decline in humans and animal models. Our data suggests that PGRN plays a key role in maintaining neuronal function during aging and supports the notion that PGRN is a trophic factor essential for long-term neuronal survival. |
| Author | Yu, Xin Leissring, Malcolm Lewis, Jada Lin, Wen-Lang Dickson, Dennis W. Sheng, Hong Yamanouchi, Keitaro Hou, Harold Hutton, Michael L. Innes, Amy E. Nishihara, Masugi Chiba, Shuichi Petrucelli, Leonard Gass, Jennifer Xu, Ya-fei Ahmed, Zeshan McGowan, Eileen |
| Author_xml | – sequence: 1 givenname: Zeshan surname: Ahmed fullname: Ahmed, Zeshan organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida – sequence: 2 givenname: Hong surname: Sheng fullname: Sheng, Hong organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida – sequence: 3 givenname: Ya-fei surname: Xu fullname: Xu, Ya-fei organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida – sequence: 4 givenname: Wen-Lang surname: Lin fullname: Lin, Wen-Lang organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida – sequence: 5 givenname: Amy E. surname: Innes fullname: Innes, Amy E. organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida – sequence: 6 givenname: Jennifer surname: Gass fullname: Gass, Jennifer organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida – sequence: 7 givenname: Xin surname: Yu fullname: Yu, Xin organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida – sequence: 8 givenname: Harold surname: Hou fullname: Hou, Harold organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida – sequence: 9 givenname: Shuichi surname: Chiba fullname: Chiba, Shuichi organization: Department of Veterinary Physiology, Veterinary Medical Science, University of Tokyo, Tokyo, Japan – sequence: 10 givenname: Keitaro surname: Yamanouchi fullname: Yamanouchi, Keitaro organization: Department of Veterinary Physiology, Veterinary Medical Science, University of Tokyo, Tokyo, Japan – sequence: 11 givenname: Malcolm surname: Leissring fullname: Leissring, Malcolm organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida – sequence: 12 givenname: Leonard surname: Petrucelli fullname: Petrucelli, Leonard organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida – sequence: 13 givenname: Masugi surname: Nishihara fullname: Nishihara, Masugi organization: Department of Veterinary Physiology, Veterinary Medical Science, University of Tokyo, Tokyo, Japan – sequence: 14 givenname: Michael L. surname: Hutton fullname: Hutton, Michael L. organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida – sequence: 15 givenname: Eileen surname: McGowan fullname: McGowan, Eileen organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida – sequence: 16 givenname: Dennis W. surname: Dickson fullname: Dickson, Dennis W. email: dickson.dennis@mayo.edu organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida – sequence: 17 givenname: Jada surname: Lewis fullname: Lewis, Jada organization: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22974364$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20522652$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUltv0zAYtdAQ6wZ_gAfkF7SnDF8SJ0FoUjXBQBSB6Hi2XOdL5i61OzueNH49Dmm5TGJIkRzH5xJ_5xyhA-ssIPScklPGC_5KrbdquDplJH0gNalp8QjNaMGKjNGaHqAZIYRldZ6TQ3QUwjptBa_IE3TISMGYKNgMfZ9rDT14NUCDF2br2hi0sS6YgJVt8LeVuYlmMFYNxllsLL7wysY-vXy0Tl-7OOBPRgNexq6DMGCFv7oecOs8_uJdtwenZxmTVQht7PG8M7Z7ih63qg_wbLceo8t3by_P32eLzxcfzueLTItCDJmmjLVUlysNQlSNIqUohSq0bivKW6ialWq4YKKpy1ITnquallAqoYBBLmp-jM4m2W1cbaDRYAevern1ZqP8nXTKyL9PrLmSnbuVrKq5KPMkcLIT8O4mpjvKjQlpaL2y4GKQJecip7wgCfniT6tfHvtxJ8DLHUAFrfo2TUeb8BvH6uQnRstqwmnvQvDQSm2GnwmkPzS9pESODZBTA-TYADk1IFHZPepe_UHSm4kEKYdbA16mEoDV0BgPepCNMw_Tz-7RdcrcpBtewx2EtYvepoQllYFJIpdjL8daUiIIqcoxo9f_Fvif-w8frvTl |
| CODEN | AJPAA4 |
| CitedBy_id | crossref_primary_10_3389_fnins_2020_586107 crossref_primary_10_1016_j_nbd_2011_10_016 crossref_primary_10_1016_j_ajhg_2012_04_021 crossref_primary_10_1016_j_bbadis_2017_07_014 crossref_primary_10_1111_j_1471_4159_2010_06961_x crossref_primary_10_1002_embj_201385857 crossref_primary_10_1371_journal_pone_0118956 crossref_primary_10_1186_1750_1326_7_33 crossref_primary_10_1016_j_tem_2013_08_003 crossref_primary_10_3390_biomedicines10081905 crossref_primary_10_1371_journal_pone_0018778 crossref_primary_10_1038_s41467_020_18405_9 crossref_primary_10_1111_j_1582_4934_2011_01350_x crossref_primary_10_1038_s41423_019_0274_5 crossref_primary_10_1016_j_ebiom_2018_01_022 crossref_primary_10_1093_brain_aws006 crossref_primary_10_1007_s00401_015_1475_3 crossref_primary_10_1016_j_pneurobio_2011_04_006 crossref_primary_10_1186_s40478_019_0856_6 crossref_primary_10_1016_j_nbd_2017_06_012 crossref_primary_10_1186_alzrt102 crossref_primary_10_1080_14728222_2018_1487951 crossref_primary_10_1007_s40142_014_0063_5 crossref_primary_10_1016_j_neuron_2011_09_011 crossref_primary_10_1074_jbc_R112_399170 crossref_primary_10_1523_ENEURO_0061_14_2015 crossref_primary_10_1038_s41419_021_03506_0 crossref_primary_10_1016_j_ajhg_2010_11_002 crossref_primary_10_1038_s41467_024_50076_8 crossref_primary_10_1007_s12035_012_8236_2 crossref_primary_10_3390_cells8030230 crossref_primary_10_1016_j_neuron_2010_11_014 crossref_primary_10_1093_brain_awae074 crossref_primary_10_1186_s12974_024_03039_1 crossref_primary_10_15252_embr_202050197 crossref_primary_10_1007_s00401_018_1861_8 crossref_primary_10_1016_j_nbd_2023_106138 crossref_primary_10_1016_j_brainres_2014_09_023 crossref_primary_10_3389_fnins_2019_00335 crossref_primary_10_3389_fcell_2022_836196 crossref_primary_10_1371_journal_pone_0035115 crossref_primary_10_1523_JNEUROSCI_3498_17_2019 crossref_primary_10_1016_j_jmb_2020_02_033 crossref_primary_10_1186_s40035_022_00296_z crossref_primary_10_1016_j_tins_2014_04_003 crossref_primary_10_1007_s40265_020_01440_7 crossref_primary_10_1038_s41598_021_90366_5 crossref_primary_10_14336_AD_2017_1127 crossref_primary_10_1016_j_brainres_2012_01_075 crossref_primary_10_1007_s12031_011_9622_3 crossref_primary_10_1038_s41419_022_05290_x crossref_primary_10_1016_S0001_4079_19_31683_8 crossref_primary_10_1186_s40478_017_0412_1 crossref_primary_10_1016_j_ebiom_2016_10_010 crossref_primary_10_3389_fnmol_2021_713031 crossref_primary_10_1016_j_gene_2022_146513 crossref_primary_10_1186_s13195_020_00649_8 crossref_primary_10_1186_s13024_021_00513_9 crossref_primary_10_1093_hmg_ddw252 crossref_primary_10_1007_s00109_018_1703_0 crossref_primary_10_1007_s00401_012_0979_3 crossref_primary_10_1096_fj_10_161471 crossref_primary_10_1080_21691401_2024_2402298 crossref_primary_10_1016_j_arr_2016_04_008 crossref_primary_10_1016_j_bbadis_2019_165571 crossref_primary_10_1016_j_bbadis_2019_165570 crossref_primary_10_1186_s12974_023_02965_w crossref_primary_10_3389_fimmu_2024_1417836 crossref_primary_10_1038_s12276_020_0418_9 crossref_primary_10_1007_s00401_014_1262_6 crossref_primary_10_1016_j_neuropharm_2020_107948 crossref_primary_10_3390_cells9020350 crossref_primary_10_1007_s12031_011_9569_4 crossref_primary_10_1371_journal_pone_0182896 crossref_primary_10_1016_j_conb_2021_10_001 crossref_primary_10_1093_hmg_ddx011 crossref_primary_10_1172_jci_insight_136147 crossref_primary_10_1016_j_neurobiolaging_2018_03_007 crossref_primary_10_1007_s12035_024_04190_9 crossref_primary_10_1016_j_jalz_2012_03_002 crossref_primary_10_1038_s42255_020_00270_x crossref_primary_10_3390_cells10010150 crossref_primary_10_1093_hmg_ddac271 crossref_primary_10_1016_j_celrep_2024_114985 crossref_primary_10_1111_cpr_13481 crossref_primary_10_1371_journal_pone_0097032 crossref_primary_10_1093_hmg_dds475 crossref_primary_10_1038_s41392_023_01484_7 crossref_primary_10_1093_hmg_ddx247 crossref_primary_10_1016_j_brainres_2013_06_006 crossref_primary_10_1084_jem_20160999 crossref_primary_10_3390_cells12131803 crossref_primary_10_1016_j_neuroscience_2015_12_006 crossref_primary_10_1016_j_ajpath_2016_08_006 crossref_primary_10_1111_jnc_13622 crossref_primary_10_3389_fnagi_2014_00204 crossref_primary_10_1016_j_neurobiolaging_2013_04_019 crossref_primary_10_1186_s13024_018_0281_5 crossref_primary_10_3390_ijms20235866 crossref_primary_10_1016_j_neuron_2011_07_021 crossref_primary_10_1083_jcb_201502029 crossref_primary_10_1186_s40478_020_01037_x crossref_primary_10_3390_brainsci13101474 crossref_primary_10_1016_j_isci_2023_107247 crossref_primary_10_1523_JNEUROSCI_6103_11_2013 crossref_primary_10_1016_j_neuron_2010_09_034 crossref_primary_10_1038_s41467_018_02821_z crossref_primary_10_1007_s00401_012_1029_x crossref_primary_10_1093_brain_awx198 crossref_primary_10_1093_brain_awz377 crossref_primary_10_1002_ana_23722 crossref_primary_10_1007_s12035_015_9473_y crossref_primary_10_3390_ijms23020629 crossref_primary_10_1111_jnc_15378 crossref_primary_10_1038_labinvest_2014_113 crossref_primary_10_1016_j_stemcr_2023_01_012 crossref_primary_10_1371_journal_pone_0098184 crossref_primary_10_1083_jcb_201603079 crossref_primary_10_1016_j_atherosclerosis_2018_08_042 crossref_primary_10_1038_s41418_017_0043_x crossref_primary_10_1007_s13311_023_01348_6 crossref_primary_10_1093_brain_awx060 crossref_primary_10_1186_s12974_023_02735_8 crossref_primary_10_3389_fneur_2021_754045 crossref_primary_10_1007_s11481_013_9495_z crossref_primary_10_1073_pnas_1722344115 crossref_primary_10_1084_jem_20140214 crossref_primary_10_1016_j_dci_2023_105115 crossref_primary_10_15252_embr_202050241 crossref_primary_10_1016_j_nbd_2022_105891 crossref_primary_10_1523_JNEUROSCI_3081_17_2018 crossref_primary_10_1002_acn3_51242 crossref_primary_10_1016_j_celrep_2021_109399 crossref_primary_10_1186_s40478_023_01544_7 crossref_primary_10_1007_s12035_015_9507_5 crossref_primary_10_1111_febs_16638 crossref_primary_10_1111_bpa_13312 crossref_primary_10_1016_j_nbd_2011_08_029 crossref_primary_10_3390_ijms18040769 crossref_primary_10_1016_j_matbio_2017_10_002 crossref_primary_10_15252_emmm_201809711 crossref_primary_10_1007_s12035_012_8380_8 crossref_primary_10_1186_s40478_023_01571_4 crossref_primary_10_15252_emmm_201809712 crossref_primary_10_1007_s12031_011_9553_z crossref_primary_10_1038_nrn_2017_36 crossref_primary_10_1016_j_nbd_2021_105360 crossref_primary_10_1186_s40478_023_01510_3 crossref_primary_10_1007_s11910_016_0707_9 crossref_primary_10_3390_ijms232213753 crossref_primary_10_1016_j_jneumeth_2019_108422 crossref_primary_10_1016_j_neuroscience_2012_11_032 crossref_primary_10_1186_s12974_017_1000_9 crossref_primary_10_1523_ENEURO_0100_17_2017 crossref_primary_10_1038_s41591_024_02973_0 crossref_primary_10_1016_j_celrep_2012_09_007 crossref_primary_10_1186_1742_2094_8_65 crossref_primary_10_1074_jbc_M112_441949 crossref_primary_10_1007_s00018_011_0861_9 crossref_primary_10_1016_j_cell_2015_11_008 crossref_primary_10_1016_j_yjmcc_2019_12_009 crossref_primary_10_1186_1750_1326_5_41 crossref_primary_10_1038_nm_3672 crossref_primary_10_1111_gbb_12300 crossref_primary_10_1016_j_nbd_2021_105314 crossref_primary_10_1016_j_neuron_2017_06_026 crossref_primary_10_1038_nm_2224 crossref_primary_10_1080_21678707_2019_1703672 crossref_primary_10_1016_j_bbadis_2019_165614 crossref_primary_10_1016_j_addr_2022_114464 crossref_primary_10_1016_j_celrep_2017_08_056 crossref_primary_10_3389_fnins_2021_775391 crossref_primary_10_1126_scitranslmed_aah5642 crossref_primary_10_2165_11640070_000000000_00000 crossref_primary_10_15252_embr_202050219 crossref_primary_10_1016_j_nbd_2018_11_011 crossref_primary_10_1038_s41467_024_49908_4 crossref_primary_10_1093_braincomms_fcab310 crossref_primary_10_1007_s11910_013_0366_z crossref_primary_10_26508_lsa_202000874 crossref_primary_10_1016_j_jmb_2019_01_027 crossref_primary_10_3389_fnagi_2016_00035 crossref_primary_10_1172_JCI63113 crossref_primary_10_1523_JNEUROSCI_5336_12_2013 crossref_primary_10_1002_path_4043 crossref_primary_10_1007_s00401_017_1668_z crossref_primary_10_1186_s40478_014_0078_x crossref_primary_10_1177_1533317512467681 crossref_primary_10_1186_2047_9158_2_8 crossref_primary_10_1016_j_omtm_2021_05_009 crossref_primary_10_1093_hmg_ddt057 crossref_primary_10_1002_jcp_26583 crossref_primary_10_1016_j_nbd_2023_106108 crossref_primary_10_1186_s13024_016_0114_3 crossref_primary_10_1002_acn3_51165 crossref_primary_10_1007_s12031_011_9625_0 crossref_primary_10_1016_j_neuroscience_2013_06_049 crossref_primary_10_1038_s41467_018_06449_x crossref_primary_10_1080_21678707_2017_1360182 crossref_primary_10_1016_j_neulet_2012_05_070 crossref_primary_10_1016_j_ymthe_2018_11_013 crossref_primary_10_1038_ncomms15277 crossref_primary_10_1073_pnas_1100650108 crossref_primary_10_1016_j_celrep_2021_109581 crossref_primary_10_3390_ijms242115946 crossref_primary_10_1016_j_isci_2023_108362 crossref_primary_10_3389_fphar_2023_1227220 crossref_primary_10_1073_pnas_2022115118 crossref_primary_10_1186_s12950_023_00327_0 crossref_primary_10_1016_j_ymgme_2015_08_008 crossref_primary_10_1146_annurev_pathmechdis_012418_012955 crossref_primary_10_3390_ijms23105729 crossref_primary_10_1111_nan_12536 crossref_primary_10_1073_pnas_2210442120 crossref_primary_10_1016_j_mcn_2020_103553 crossref_primary_10_1038_s41598_021_85494_x crossref_primary_10_1186_s40478_018_0631_0 crossref_primary_10_1016_j_jbc_2021_101159 |
| Cites_doi | 10.1016/S0304-3940(98)00008-1 10.1016/S0167-4943(01)00219-9 10.1007/s00018-008-7581-9 10.1002/ana.20963 10.1016/j.brainres.2007.09.021 10.2174/156720506779025251 10.1002/j.1460-2075.1995.tb00029.x 10.1186/gb-2005-6-6-r48 10.1002/path.2580 10.1126/science.1134108 10.1093/brain/awl271 10.1084/jem.20091568 10.1517/14712598.8.7.969 10.1212/01.wnl.0000325058.10218.fc 10.1016/j.bbr.2007.07.020 10.1098/rstb.2008.0213 10.1002/glia.10154 10.1002/dvdy.10341 10.1177/019262330002800104 10.1111/j.1365-2990.2007.00878.x 10.1038/nature05016 10.1007/BF00691284 10.1083/jcb.200712039 10.1097/nen.0b013e31803020cf 10.1369/jhc.6A7156.2007 10.1186/1742-2094-4-7 10.1093/brain/awn352 10.1016/0306-4522(80)90053-6 10.1007/s11064-009-9922-y 10.1007/s00401-007-0223-8 10.1073/pnas.89.5.1715 10.1007/s00109-003-0474-3 10.1111/j.1471-4159.2009.06211.x 10.1262/jrd.20239 10.1002/jnr.10157 10.1523/JNEUROSCI.3421-07.2007 10.1002/ana.21397 10.1196/annals.1404.008 10.1094/MPMI.1999.12.12.1114 10.1177/002215540004800713 |
| ContentType | Journal Article |
| Copyright | 2010 American Society for Investigative Pathology American Society for Investigative Pathology 2015 INIST-CNRS Copyright © American Society for Investigative Pathology 2010 |
| Copyright_xml | – notice: 2010 American Society for Investigative Pathology – notice: American Society for Investigative Pathology – notice: 2015 INIST-CNRS – notice: Copyright © American Society for Investigative Pathology 2010 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.2353/ajpath.2010.090915 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1525-2191 |
| EndPage | 324 |
| ExternalDocumentID | PMC2893674 20522652 22974364 10_2353_ajpath_2010_090915 S0002944010600879 1_s2_0_S0002944010600879 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: NIA NIH HHS grantid: P50 AG016574 |
| GroupedDBID | --- --K -~X .1- .55 .FO .GJ 0R~ 1P~ 23M 2WC 34R 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 6J9 7-5 7X7 88E 88I 8AF 8C1 8FE 8FH 8FI 8FJ 8R4 8R5 AAEDT AAEDW AAFWJ AAIKJ AALRI AAQFI AAQXK AAXUO AAYWO ABCQX ABJNI ABLJU ABMAC ABOCM ABUWG ABWVN ACGFO ACGOD ACPRK ACRPL ACVFH ADBBV ADCNI ADEZE ADHJS ADMUD ADNMO ADVLN AENEX AEUPX AEVXI AFFNX AFJKZ AFKRA AFPUW AFRHN AFTJW AGCQF AGHFR AGQPQ AHDRD AHMBA AI. AIGII AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ APXCP ASPBG AVWKF AZFZN AZQEC BAWUL BBNVY BELOY BENPR BHPHI BPHCQ BVXVI C1A CCPQU CS3 DIK DWQXO E3Z EBS EFJIC EFKBS EJD F5P FDB FEDTE FGOYB FYUFA GBLVA GNUQQ GX1 H13 HCIFZ HMCUK HVGLF HX~ HZ~ IH2 IXB J5H KOM KQ8 L7B LID LK8 M1P M2P M41 M7P MVM N9A O9- OG~ OHT OK1 OS. P2P PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PUEGO Q2X R2- ROL RPM SEL SES SJN SSZ TIP TR2 UKHRP VH1 WH7 WOQ X7M XH2 Y6R YHG YNH Z5R ZGI ZXP 3V. AACTN ADPAM AFCTW ALIPV VXZ AAIAV ABVKL AGZHU ALXNB NCXOZ ZA5 AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c656t-c122f1c7bce668da07676a5ccf813fe8dbad3626d977c034a917e7a6ae2e4693 |
| IEDL.DBID | IXB |
| ISSN | 0002-9440 1525-2191 |
| IngestDate | Thu Aug 21 18:05:03 EDT 2025 Mon Jul 21 11:51:27 EDT 2025 Thu Apr 03 07:07:50 EDT 2025 Mon Jul 21 09:14:14 EDT 2025 Thu Apr 24 23:11:05 EDT 2025 Tue Jul 01 02:34:20 EDT 2025 Fri Feb 23 02:34:42 EST 2024 Sun Feb 23 10:19:49 EST 2025 Tue Aug 26 19:05:08 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Progranulin Ageing Metabolic diseases Enzymopathy Lipofuscinosis Genetic disease Anatomic pathology Ubiquitination Animal Knockout mouse Pigments Lipoidosis Age |
| Language | English |
| License | http://www.elsevier.com/open-access/userlicense/1.0 CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c656t-c122f1c7bce668da07676a5ccf813fe8dbad3626d977c034a917e7a6ae2e4693 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.clinicalkey.com/#!/content/1-s2.0-S0002944010600879 |
| PMID | 20522652 |
| PQID | 733641350 |
| PQPubID | 23479 |
| PageCount | 14 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2893674 proquest_miscellaneous_733641350 pubmed_primary_20522652 pascalfrancis_primary_22974364 crossref_citationtrail_10_2353_ajpath_2010_090915 crossref_primary_10_2353_ajpath_2010_090915 elsevier_sciencedirect_doi_10_2353_ajpath_2010_090915 elsevier_clinicalkeyesjournals_1_s2_0_S0002944010600879 elsevier_clinicalkey_doi_10_2353_ajpath_2010_090915 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2010-07-01 |
| PublicationDateYYYYMMDD | 2010-07-01 |
| PublicationDate_xml | – month: 07 year: 2010 text: 2010-07-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Bethesda, MD |
| PublicationPlace_xml | – name: Bethesda, MD – name: United States |
| PublicationTitle | The American journal of pathology |
| PublicationTitleAlternate | Am J Pathol |
| PublicationYear | 2010 |
| Publisher | Elsevier Inc American Society for Investigative Pathology |
| Publisher_xml | – name: Elsevier Inc – name: American Society for Investigative Pathology |
| References | Shimada, Keino, Kawamura, Chiba, Hosokawa (bib38) 2008; 34 Zhang, Xu, Dickey, Buratti, Baralle, Bailey, Pickering-Brown, Dickson, Petrucelli (bib30) 2007; 27 Kumagai, Chiba, Hosono, Fujii, Kawamura, Keino, Yoshikawa, Ishii, Saitoh, Satoh, Shimada, Hosokawa (bib39) 2007; 1185 Ghidoni, Benussi, Glionna, Franzoni, Binetti (bib9) 2008; 71 Carter, Greenhall, Yoshida, Fuchs, Helton, Swaroop, Lockhart, Barlow (bib40) 2005; 6 Streit (bib37) 2002 Cook, Zhang, Xu, Dickson, Petrucelli (bib27) 2008; 8 Daniel, Daniels, He, Bateman (bib1) 2003; 227 Cruts, Kumar-Singh, Van Broeckhoven (bib7) 2006; 3 Chiba, Matsuwaki, Yamanouchi, Nishihara (bib20) 2009; 55 Jolly, Palmer, Dalefield (bib33) 2002; 34 Yin, Banerjee, Thomas, Zhou, Qian, Jia, Ma, Ma, Iadecola, Beal, Nathan, Ding (bib32) 2009; 207 Josephs, Ahmed, Katsuse, Parisi, Boeve, Knopman, Petersen, Davies, Duara, Graff-Radford, Uitti, Rademakers, Adamson, Baker, Hutton, Dickson (bib13) 2007; 66 He, Bateman (bib5) 2003; 81 Mackenzie, Baker, Pickering-Brown, Hsiung, Lindholm, Dwosh, Gass, Cannon, Rademakers, Hutton, Feldman (bib14) 2006; 129 Kayasuga, Chiba, Suzuki, Kikusui, Matsuwaki, Yamanouchi, Kotaki, Horai, Iwakura, Nishihara (bib19) 2007; 185 Mukherjee, Pastor, Cairns, Chakraverty, Kauwe, Shears, Behrens, Budde, Hinrichs, Norton, Levitch, Taylor-Reinwald, Gitcho, Tu, Tenenholz Grinberg, Liscic, Armendariz, Morris, Goate (bib15) 2006; 60 Ahmed, Shaw, Sharma, Yang, McGowan, Dickson (bib24) 2007; 55 Ghandour, Langley, Vincendon, Gombos, Filippi, Limozin, Dalmasso, Laurent (bib23) 1980; 5 Double, Dedov, Fedorow, Kettle, Halliday, Garner, Brunk (bib28) 2008; 65 Coppola, Karydas, Rademakers, Wang, Baker, Hutton, Miller, Geschwind (bib8) 2008; 64 Dickson, Crystal, Mattiace, Kress, Schwagerl, Ksiezak-Reding, Davies, Yen (bib25) 1989; 78 Pereson, Wils, Kleinberger, McGowan, Vandewoestyne, Van Broeck, Joris, Cuijt, Deforce, Hutton, Van Broeckhoven, Kumar-Singh (bib31) 2009; 219 Avrova, Stewart, De Jong, Heilbronn, Lyon, Birch (bib2) 1999; 12 Ahmed, Mackenzie, Hutton, Dickson (bib4) 2007; 4 Suzuki, Yoshida, Nishihara, Takahashi (bib18) 1998; 242 Jung, Bader, Grune (bib34) 2007; 1119 Matzilevich, Rall, Moore, Grill, Dash (bib42) 2002; 67 Peters, Palay, Webster (bib29) 1991 Neumann, Sampathu, Kwong, Truax, Micsenyi, Chou, Bruce, Schuck, Grossman, Clark, McCluskey, Miller, Masliah, Mackenzie, Feldman, Feiden, Kretzschmar, Trojanowski, Lee (bib12) 2006; 314 Van Damme, Van Hoecke, Lambrechts, Vanacker, Bogaert, van Swieten, Carmeliet, Van Den Bosch, Robberecht (bib17) 2008; 181 Streit (bib43) 2002; 40 Margolis, Pickett (bib22) 1956; 5 Daniel, He, Carmichael, Halper, Bateman (bib16) 2000; 48 Saftig, Hetman, Schmahl, Weber, Heine, Mossmann, Koster, Hess, Evers, von Figura, Peters (bib26) 1995; 14 Streit (bib36) 2000; 28 Finch, Baker, Crook, Swanson, Kuntz, Surtees, Bisceglio, Rovelet-Lecrux, Boeve, Petersen, Dickson, Younkin, Deramecourt, Crook, Graff-Radford, Rademakers (bib10) 2009; 132 Bhandari, Palfree, Bateman (bib3) 1992; 89 Bianco, Wilson (bib35) 2009; 364 Baker, Mackenzie, Pickering-Brown, Gass, Rademakers, Lindholm, Snowden, Adamson, Sadovnick, Rollinson, Cannon, Dwosh, Neary, Melquist, Richardson, Dickson, Berger, Eriksen, Robinson, Zehr, Dickey, Crook, McGowan, Mann, Boeve, Feldman, Hutton (bib6) 2006; 442 Mackenzie (bib11) 2007; 114 Dormann, Capell, Carlson, Shankaran, Rodde, Neumann, Kremmer, Matsuwaki, Yamanouchi, Nishihara, Haass (bib21) 2009; 110 Takeda (bib41) 2009; 34 Ghidoni (10.2353/ajpath.2010.090915_bib9) 2008; 71 Jung (10.2353/ajpath.2010.090915_bib34) 2007; 1119 Daniel (10.2353/ajpath.2010.090915_bib1) 2003; 227 Neumann (10.2353/ajpath.2010.090915_bib12) 2006; 314 Pereson (10.2353/ajpath.2010.090915_bib31) 2009; 219 Coppola (10.2353/ajpath.2010.090915_bib8) 2008; 64 Takeda (10.2353/ajpath.2010.090915_bib41) 2009; 34 Double (10.2353/ajpath.2010.090915_bib28) 2008; 65 Cook (10.2353/ajpath.2010.090915_bib27) 2008; 8 Ahmed (10.2353/ajpath.2010.090915_bib4) 2007; 4 Margolis (10.2353/ajpath.2010.090915_bib22) 1956; 5 Yin (10.2353/ajpath.2010.090915_bib32) 2009; 207 Kayasuga (10.2353/ajpath.2010.090915_bib19) 2007; 185 Ghandour (10.2353/ajpath.2010.090915_bib23) 1980; 5 Shimada (10.2353/ajpath.2010.090915_bib38) 2008; 34 He (10.2353/ajpath.2010.090915_bib5) 2003; 81 Mackenzie (10.2353/ajpath.2010.090915_bib11) 2007; 114 Mackenzie (10.2353/ajpath.2010.090915_bib14) 2006; 129 Carter (10.2353/ajpath.2010.090915_bib40) 2005; 6 Avrova (10.2353/ajpath.2010.090915_bib2) 1999; 12 Matzilevich (10.2353/ajpath.2010.090915_bib42) 2002; 67 Cruts (10.2353/ajpath.2010.090915_bib7) 2006; 3 Peters (10.2353/ajpath.2010.090915_bib29) 1991 Van Damme (10.2353/ajpath.2010.090915_bib17) 2008; 181 Bianco (10.2353/ajpath.2010.090915_bib35) 2009; 364 Saftig (10.2353/ajpath.2010.090915_bib26) 1995; 14 Mukherjee (10.2353/ajpath.2010.090915_bib15) 2006; 60 Ahmed (10.2353/ajpath.2010.090915_bib24) 2007; 55 Zhang (10.2353/ajpath.2010.090915_bib30) 2007; 27 Streit (10.2353/ajpath.2010.090915_bib37) 2002 Daniel (10.2353/ajpath.2010.090915_bib16) 2000; 48 Jolly (10.2353/ajpath.2010.090915_bib33) 2002; 34 Dickson (10.2353/ajpath.2010.090915_bib25) 1989; 78 Chiba (10.2353/ajpath.2010.090915_bib20) 2009; 55 Finch (10.2353/ajpath.2010.090915_bib10) 2009; 132 Josephs (10.2353/ajpath.2010.090915_bib13) 2007; 66 Suzuki (10.2353/ajpath.2010.090915_bib18) 1998; 242 Streit (10.2353/ajpath.2010.090915_bib36) 2000; 28 Kumagai (10.2353/ajpath.2010.090915_bib39) 2007; 1185 Dormann (10.2353/ajpath.2010.090915_bib21) 2009; 110 Bhandari (10.2353/ajpath.2010.090915_bib3) 1992; 89 Streit (10.2353/ajpath.2010.090915_bib43) 2002; 40 Baker (10.2353/ajpath.2010.090915_bib6) 2006; 442 Am J Pathol. 2010 Oct;177(4):2146 |
| References_xml | – volume: 89 start-page: 1715 year: 1992 end-page: 1719 ident: bib3 article-title: Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains publication-title: Proc Natl Acad Sci USA – volume: 65 start-page: 1669 year: 2008 end-page: 1682 ident: bib28 article-title: The comparative biology of neuromelanin and lipofuscin in the human brain publication-title: Cell Mol Life Sci – volume: 5 start-page: 459 year: 1956 end-page: 474 ident: bib22 article-title: New applications of the Luxol fast blue myelin stain publication-title: Lab Invest – volume: 64 start-page: 92 year: 2008 end-page: 96 ident: bib8 article-title: Gene expression study on peripheral blood identifies progranulin mutations publication-title: Ann Neurol – volume: 5 start-page: 559 year: 1980 end-page: 571 ident: bib23 article-title: Immunochemical and immunohistochemical study of carbonic anhydrase II in adult rat cerebellum: a marker for oligodendrocytes publication-title: Neuroscience – volume: 314 start-page: 130 year: 2006 end-page: 133 ident: bib12 article-title: Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis publication-title: Science – volume: 227 start-page: 593 year: 2003 end-page: 599 ident: bib1 article-title: Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development publication-title: Dev Dyn – volume: 185 start-page: 110 year: 2007 end-page: 118 ident: bib19 article-title: Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene publication-title: Behav Brain Res – volume: 3 start-page: 485 year: 2006 end-page: 491 ident: bib7 article-title: Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21 publication-title: Curr Alzheimer Res – volume: 71 start-page: 1235 year: 2008 end-page: 1239 ident: bib9 article-title: Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration publication-title: Neurology – volume: 181 start-page: 37 year: 2008 end-page: 41 ident: bib17 article-title: Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival publication-title: J Cell Biol – volume: 207 start-page: 117 year: 2009 end-page: 128 ident: bib32 article-title: Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice publication-title: J Exp Med – volume: 242 start-page: 127 year: 1998 end-page: 130 ident: bib18 article-title: Identification of a sex steroid-inducible gene in the neonatal rat hypothalamus publication-title: Neurosci Lett – volume: 6 start-page: R48 year: 2005 ident: bib40 article-title: Mechanisms of aging in senescence-accelerated mice publication-title: Genome Biol – start-page: 34 year: 1991 end-page: 38 ident: bib29 publication-title: The fine structure of the nervous system: neurons and their supporting cells – volume: 114 start-page: 49 year: 2007 end-page: 54 ident: bib11 article-title: The neuropathology and clinical phenotype of FTD with progranulin mutations publication-title: Acta Neuropathol – volume: 129 start-page: 3081 year: 2006 end-page: 3090 ident: bib14 article-title: The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene publication-title: Brain – volume: 78 start-page: 572 year: 1989 end-page: 584 ident: bib25 article-title: Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques publication-title: Acta Neuropathol – volume: 1119 start-page: 97 year: 2007 end-page: 111 ident: bib34 article-title: Lipofuscin: formation, distribution, and metabolic consequences publication-title: Ann NY Acad Sci – volume: 67 start-page: 646 year: 2002 end-page: 663 ident: bib42 article-title: High-density microarray analysis of hippocampal gene expression following experimental brain injury publication-title: J Neurosci Res – volume: 219 start-page: 173 year: 2009 end-page: 181 ident: bib31 article-title: Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models publication-title: J Pathol – volume: 14 start-page: 3599 year: 1995 end-page: 3608 ident: bib26 article-title: Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells publication-title: EMBO J – volume: 48 start-page: 999 year: 2000 end-page: 1009 ident: bib16 article-title: Cellular localization of gene expression for progranulin publication-title: J Histochem Cytochem – volume: 27 start-page: 10530 year: 2007 end-page: 10534 ident: bib30 article-title: Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43 publication-title: J Neurosci – volume: 4 start-page: 7 year: 2007 ident: bib4 article-title: Progranulin in frontotemporal lobar degeneration and neuroinflammation publication-title: J Neuroinflammation – volume: 60 start-page: 314 year: 2006 end-page: 322 ident: bib15 article-title: HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin publication-title: Ann Neurol – volume: 28 start-page: 28 year: 2000 end-page: 30 ident: bib36 article-title: Microglial response to brain injury: a brief synopsis publication-title: Toxicol Pathol – start-page: 11 year: 2002 end-page: 24 ident: bib37 article-title: Microglia and the response to brain injury publication-title: Ernst Schering Res Found Workshop – volume: 55 start-page: 518 year: 2009 end-page: 522 ident: bib20 article-title: Alteration in anxiety with relation to the volume of the locus ceruleus in progranulin-deficient mice publication-title: J Reprod Dev – volume: 1185 start-page: 75 year: 2007 end-page: 85 ident: bib39 article-title: Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse publication-title: Brain Res – volume: 8 start-page: 969 year: 2008 end-page: 978 ident: bib27 article-title: TDP-43 in neurodegenerative disorders publication-title: Expert Opin Biol Ther – volume: 66 start-page: 142 year: 2007 end-page: 151 ident: bib13 article-title: Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations publication-title: J Neuropathol Exp Neurol – volume: 110 start-page: 1082 year: 2009 end-page: 1094 ident: bib21 article-title: Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin publication-title: J Neurochem – volume: 34 start-page: 33 year: 2008 end-page: 51 ident: bib38 article-title: Limbic structures are prone to age-related impairments in proteasome activity and neuronal ubiquitinated inclusions in SAMP10 mouse: a model of cerebral degeneration publication-title: Neuropathol Appl Neurobiol – volume: 12 start-page: 1114 year: 1999 end-page: 1119 ident: bib2 article-title: A cysteine protease gene is expressed early in resistant potato interactions with Phytophthora infestans publication-title: Mol Plant Microbe Interact – volume: 81 start-page: 600 year: 2003 end-page: 612 ident: bib5 article-title: Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis publication-title: J Mol Med – volume: 34 start-page: 639 year: 2009 end-page: 659 ident: bib41 article-title: Senescence-accelerated mouse (SAM) with special references to neurodegeneration models. SAMP8 and SAMP10 mice publication-title: Neurochem Res – volume: 132 start-page: 583 year: 2009 end-page: 591 ident: bib10 article-title: Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members publication-title: Brain – volume: 55 start-page: 687 year: 2007 end-page: 700 ident: bib24 article-title: Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry publication-title: J Histochem Cytochem – volume: 40 start-page: 133 year: 2002 end-page: 139 ident: bib43 article-title: Microglia as neuroprotective, immunocompetent cells of the CNS publication-title: Glia – volume: 442 start-page: 916 year: 2006 end-page: 919 ident: bib6 article-title: Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 publication-title: Nature – volume: 34 start-page: 205 year: 2002 end-page: 217 ident: bib33 article-title: The analytical approach to the nature of lipofuscin (age pigment) publication-title: Arch Gerontol Geriatr – volume: 364 start-page: 1005 year: 2009 end-page: 1020 ident: bib35 article-title: Review. The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain publication-title: Philos Trans R Soc Lond B Biol Sci – volume: 242 start-page: 127 year: 1998 ident: 10.2353/ajpath.2010.090915_bib18 article-title: Identification of a sex steroid-inducible gene in the neonatal rat hypothalamus publication-title: Neurosci Lett doi: 10.1016/S0304-3940(98)00008-1 – volume: 34 start-page: 205 year: 2002 ident: 10.2353/ajpath.2010.090915_bib33 article-title: The analytical approach to the nature of lipofuscin (age pigment) publication-title: Arch Gerontol Geriatr doi: 10.1016/S0167-4943(01)00219-9 – volume: 65 start-page: 1669 year: 2008 ident: 10.2353/ajpath.2010.090915_bib28 article-title: The comparative biology of neuromelanin and lipofuscin in the human brain publication-title: Cell Mol Life Sci doi: 10.1007/s00018-008-7581-9 – volume: 60 start-page: 314 year: 2006 ident: 10.2353/ajpath.2010.090915_bib15 article-title: HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin publication-title: Ann Neurol doi: 10.1002/ana.20963 – volume: 1185 start-page: 75 year: 2007 ident: 10.2353/ajpath.2010.090915_bib39 article-title: Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse publication-title: Brain Res doi: 10.1016/j.brainres.2007.09.021 – volume: 3 start-page: 485 year: 2006 ident: 10.2353/ajpath.2010.090915_bib7 article-title: Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21 publication-title: Curr Alzheimer Res doi: 10.2174/156720506779025251 – volume: 14 start-page: 3599 year: 1995 ident: 10.2353/ajpath.2010.090915_bib26 article-title: Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells publication-title: EMBO J doi: 10.1002/j.1460-2075.1995.tb00029.x – volume: 6 start-page: R48 year: 2005 ident: 10.2353/ajpath.2010.090915_bib40 article-title: Mechanisms of aging in senescence-accelerated mice publication-title: Genome Biol doi: 10.1186/gb-2005-6-6-r48 – volume: 219 start-page: 173 year: 2009 ident: 10.2353/ajpath.2010.090915_bib31 article-title: Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models publication-title: J Pathol doi: 10.1002/path.2580 – volume: 314 start-page: 130 year: 2006 ident: 10.2353/ajpath.2010.090915_bib12 article-title: Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis publication-title: Science doi: 10.1126/science.1134108 – volume: 129 start-page: 3081 year: 2006 ident: 10.2353/ajpath.2010.090915_bib14 article-title: The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene publication-title: Brain doi: 10.1093/brain/awl271 – volume: 5 start-page: 459 year: 1956 ident: 10.2353/ajpath.2010.090915_bib22 article-title: New applications of the Luxol fast blue myelin stain publication-title: Lab Invest – volume: 207 start-page: 117 year: 2009 ident: 10.2353/ajpath.2010.090915_bib32 article-title: Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice publication-title: J Exp Med doi: 10.1084/jem.20091568 – volume: 8 start-page: 969 year: 2008 ident: 10.2353/ajpath.2010.090915_bib27 article-title: TDP-43 in neurodegenerative disorders publication-title: Expert Opin Biol Ther doi: 10.1517/14712598.8.7.969 – volume: 71 start-page: 1235 year: 2008 ident: 10.2353/ajpath.2010.090915_bib9 article-title: Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration publication-title: Neurology doi: 10.1212/01.wnl.0000325058.10218.fc – volume: 185 start-page: 110 year: 2007 ident: 10.2353/ajpath.2010.090915_bib19 article-title: Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene publication-title: Behav Brain Res doi: 10.1016/j.bbr.2007.07.020 – volume: 364 start-page: 1005 year: 2009 ident: 10.2353/ajpath.2010.090915_bib35 article-title: Review. The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain publication-title: Philos Trans R Soc Lond B Biol Sci doi: 10.1098/rstb.2008.0213 – volume: 40 start-page: 133 year: 2002 ident: 10.2353/ajpath.2010.090915_bib43 article-title: Microglia as neuroprotective, immunocompetent cells of the CNS publication-title: Glia doi: 10.1002/glia.10154 – volume: 227 start-page: 593 year: 2003 ident: 10.2353/ajpath.2010.090915_bib1 article-title: Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development publication-title: Dev Dyn doi: 10.1002/dvdy.10341 – volume: 28 start-page: 28 year: 2000 ident: 10.2353/ajpath.2010.090915_bib36 article-title: Microglial response to brain injury: a brief synopsis publication-title: Toxicol Pathol doi: 10.1177/019262330002800104 – volume: 34 start-page: 33 year: 2008 ident: 10.2353/ajpath.2010.090915_bib38 article-title: Limbic structures are prone to age-related impairments in proteasome activity and neuronal ubiquitinated inclusions in SAMP10 mouse: a model of cerebral degeneration publication-title: Neuropathol Appl Neurobiol doi: 10.1111/j.1365-2990.2007.00878.x – volume: 442 start-page: 916 year: 2006 ident: 10.2353/ajpath.2010.090915_bib6 article-title: Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 publication-title: Nature doi: 10.1038/nature05016 – volume: 78 start-page: 572 year: 1989 ident: 10.2353/ajpath.2010.090915_bib25 article-title: Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques publication-title: Acta Neuropathol doi: 10.1007/BF00691284 – volume: 181 start-page: 37 year: 2008 ident: 10.2353/ajpath.2010.090915_bib17 article-title: Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival publication-title: J Cell Biol doi: 10.1083/jcb.200712039 – volume: 66 start-page: 142 year: 2007 ident: 10.2353/ajpath.2010.090915_bib13 article-title: Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations publication-title: J Neuropathol Exp Neurol doi: 10.1097/nen.0b013e31803020cf – volume: 55 start-page: 687 year: 2007 ident: 10.2353/ajpath.2010.090915_bib24 article-title: Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry publication-title: J Histochem Cytochem doi: 10.1369/jhc.6A7156.2007 – volume: 4 start-page: 7 year: 2007 ident: 10.2353/ajpath.2010.090915_bib4 article-title: Progranulin in frontotemporal lobar degeneration and neuroinflammation publication-title: J Neuroinflammation doi: 10.1186/1742-2094-4-7 – volume: 132 start-page: 583 year: 2009 ident: 10.2353/ajpath.2010.090915_bib10 article-title: Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members publication-title: Brain doi: 10.1093/brain/awn352 – volume: 5 start-page: 559 year: 1980 ident: 10.2353/ajpath.2010.090915_bib23 article-title: Immunochemical and immunohistochemical study of carbonic anhydrase II in adult rat cerebellum: a marker for oligodendrocytes publication-title: Neuroscience doi: 10.1016/0306-4522(80)90053-6 – volume: 34 start-page: 639 year: 2009 ident: 10.2353/ajpath.2010.090915_bib41 article-title: Senescence-accelerated mouse (SAM) with special references to neurodegeneration models. SAMP8 and SAMP10 mice publication-title: Neurochem Res doi: 10.1007/s11064-009-9922-y – volume: 114 start-page: 49 year: 2007 ident: 10.2353/ajpath.2010.090915_bib11 article-title: The neuropathology and clinical phenotype of FTD with progranulin mutations publication-title: Acta Neuropathol doi: 10.1007/s00401-007-0223-8 – volume: 89 start-page: 1715 year: 1992 ident: 10.2353/ajpath.2010.090915_bib3 article-title: Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.89.5.1715 – volume: 81 start-page: 600 year: 2003 ident: 10.2353/ajpath.2010.090915_bib5 article-title: Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis publication-title: J Mol Med doi: 10.1007/s00109-003-0474-3 – volume: 110 start-page: 1082 year: 2009 ident: 10.2353/ajpath.2010.090915_bib21 article-title: Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin publication-title: J Neurochem doi: 10.1111/j.1471-4159.2009.06211.x – start-page: 11 year: 2002 ident: 10.2353/ajpath.2010.090915_bib37 article-title: Microglia and the response to brain injury publication-title: Ernst Schering Res Found Workshop – volume: 55 start-page: 518 year: 2009 ident: 10.2353/ajpath.2010.090915_bib20 article-title: Alteration in anxiety with relation to the volume of the locus ceruleus in progranulin-deficient mice publication-title: J Reprod Dev doi: 10.1262/jrd.20239 – volume: 67 start-page: 646 year: 2002 ident: 10.2353/ajpath.2010.090915_bib42 article-title: High-density microarray analysis of hippocampal gene expression following experimental brain injury publication-title: J Neurosci Res doi: 10.1002/jnr.10157 – volume: 27 start-page: 10530 year: 2007 ident: 10.2353/ajpath.2010.090915_bib30 article-title: Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3421-07.2007 – volume: 64 start-page: 92 year: 2008 ident: 10.2353/ajpath.2010.090915_bib8 article-title: Gene expression study on peripheral blood identifies progranulin mutations publication-title: Ann Neurol doi: 10.1002/ana.21397 – volume: 1119 start-page: 97 year: 2007 ident: 10.2353/ajpath.2010.090915_bib34 article-title: Lipofuscin: formation, distribution, and metabolic consequences publication-title: Ann NY Acad Sci doi: 10.1196/annals.1404.008 – volume: 12 start-page: 1114 year: 1999 ident: 10.2353/ajpath.2010.090915_bib2 article-title: A cysteine protease gene is expressed early in resistant potato interactions with Phytophthora infestans publication-title: Mol Plant Microbe Interact doi: 10.1094/MPMI.1999.12.12.1114 – start-page: 34 year: 1991 ident: 10.2353/ajpath.2010.090915_bib29 – volume: 48 start-page: 999 year: 2000 ident: 10.2353/ajpath.2010.090915_bib16 article-title: Cellular localization of gene expression for progranulin publication-title: J Histochem Cytochem doi: 10.1177/002215540004800713 – reference: - Am J Pathol. 2010 Oct;177(4):2146 |
| SSID | ssj0006380 |
| Score | 2.4639332 |
| Snippet | Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its function in the central nervous system is unknown. Roles in... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 311 |
| SubjectTerms | Aging - physiology Animals Biological and medical sciences Brain - cytology Brain - metabolism Brain - pathology Errors of metabolism Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Investigative techniques, diagnostic techniques (general aspects) Lipids (lysosomal enzyme disorders, storage diseases) Medical sciences Metabolic diseases Mice Mice, Knockout Neuronal Ceroid-Lipofuscinoses - genetics Neuronal Ceroid-Lipofuscinoses - metabolism Neuronal Ceroid-Lipofuscinoses - pathology Neurons - cytology Neurons - metabolism Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Progranulins Regular Ubiquitin - metabolism Ubiquitination |
| Title | Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0002944010600879 https://www.clinicalkey.es/playcontent/1-s2.0-S0002944010600879 https://dx.doi.org/10.2353/ajpath.2010.090915 https://www.ncbi.nlm.nih.gov/pubmed/20522652 https://www.proquest.com/docview/733641350 https://pubmed.ncbi.nlm.nih.gov/PMC2893674 |
| Volume | 177 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqHhASQrwJj5UP3NBqYzt2kmOpKIWyCNFW2pvlODYNqpKFJBd-PTNxElgoRULaU9ajZDyTmW_ieRDygnGVM-MVhCUcR5gZuSxMXiy9ZUVskpxlGRYnrz-o4_Pk3UZu9sjhVAuDaZWj7Q82fbDW45XVuJurbVVhjW_M8yTBoAYbq2ERn0iyoYhv82q2xqBf8QSBcXUonOFCipX5glN_x_SuHByn_JtzurU1LWyZD7MurgKjv-dU_uKkju6Q2yO6pAeBgbtkz9X3yI31eH5-n3w_sBb8DLaHKOn7atv4Hpium7ZqqalLel5UX_uqq8InQlrV9A08DCar05MaLGfTd3QNpoWe9p_xYIoa-qm5dBSQL_04ZHqFxfA77YdRjL6Hx8FBSA_I2dHrs8Pj5Th9YWkB43VLyzj3zKaFdUplpYlTlSojrfUZE95lZWFK7GVTAoK0sUgMBH4uNco47iDmFg_Jft3U7jGhpXC5kAC8TO4SCWhe5JkpnIkT5nPnWUTYtOvajp3JcUDGpYYIBSWlg6Q0SkoHSUXk5UyzDX05rl0tJmHqqeIUbKQGt3EtVXoVlWvH17zVTLdcx_oPVYyInCl3tPmfd1zsaNrMGucQ9wmVRIROqqfBDuDhjqld07ca21oCIJFxRB4FTfxJHCPIlhz42dHReQG2GN_9p64uhlbjEI4LlSZP_pOfp-RmyLbA9OZnZL_71rvnAOK6YgHhy9uTxfCu_gBzs0e0 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLbGkAAJIW6DcBl-gCdUNbZzfeBhXEZL2wmxTuqb5TgOBE1JtyRC8LP4hZwTJ4HCGBLSpD61Pq3tc_L5O_W5EPKU8SBmKgvALeHYwkz5o0TFySjTLHGVF7MowuTkxUEwOfLerfzVFvne58JgWGWH_RbTW7Tu3hl3uzle5znm-Lo89jx0arCwWtxFVs7M1y_gt1Uvpq9Byc8433-zfDUZda0FRhoITD3SjPOM6TDRJgiiVIE3HwbK1zqLmMhMlCYqxUItKdAj7QpPgVdjQhUoww04lAK-9hK5DOQjRDCYrl4O6A_27PaUG2dnE3W48MVYfcYuw104WQwHtf-3w_D6WlWgosz21jiL_P4ew_nLobh_k9zo2Czdsxt2i2yZ4ja5suju6--Qb3taw7mG5ShSOs_XZdbAJhdllVdUFSk9SvKTJq9z-5ckzQv6FiaDwfF0VgBSl01NFwBl9LD5iBdhVNEP5bGhwLTp-zayzA6G12HTtn7MGpgONl66S5YXoZIdsl2UhblPaCpMLHwgeio2ng_eg4gjlRjleiyLTcYcwvpdl7qrhI4NOY4leESoKWk1JVFT0mrKIc8HmbWtA3LuaNErU_YZroDJEo6pc6XCs6RM1cFKJZmsuHTlH6bvEH-Q3Hh6_vmLuxuWNiyNc_AzReA5hPamJwF38DJJFaZsKollNIEA-a5D7llL_CnsIqn3Oaxnw0aHAVjSfPOTIv_UljYH918EoffgP9fzhFydLBdzOZ8ezB6SazbSA0OrH5Ht-rQxj4FA1slu-8RSIi8YIX4AieWEKw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Accelerated+Lipofuscinosis+and+Ubiquitination+in+Granulin+Knockout+Mice+Suggest+a+Role+for+Progranulin+in+Successful+Aging&rft.jtitle=The+American+journal+of+pathology&rft.au=Ahmed%2C+Zeshan&rft.au=Sheng%2C+Hong&rft.au=Xu%2C+Ya-fei&rft.au=Lin%2C+Wen-Lang&rft.date=2010-07-01&rft.pub=Elsevier+Inc&rft.issn=0002-9440&rft.volume=177&rft.issue=1&rft.spage=311&rft.epage=324&rft_id=info:doi/10.2353%2Fajpath.2010.090915&rft.externalDocID=S0002944010600879 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00029440%2FS0002944010X60023%2Fcov150h.gif |