Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice

• Published in: PloS one Vol. 10; no. 10; p. e0138880
• Main Authors: Jacouton, Elsa, Mach, Núria, Cadiou, Julie, Lapaque, Nicolas, Clément, Karine, Doré, Joël, van Hylckama Vlieg, Johan E. T., Smokvina, Tamara, Blottière, Hervé M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.10.2015; Public Library of Science (PLoS)
• Subjects: Angiopoietin-like 4 Protein; Angiopoietins - genetics; Angiopoietins - metabolism; Animal tissues; Animals; Antibiotics; Bacteria; Bacterial effects; Carbohydrate metabolism; Carbohydrates; Cellular structure; Diabetes; Diet; Endocrinology and metabolism; Energy balance; Epithelial cells; Epithelial Cells - metabolism; Fatty acids; Food and Nutrition; Functional analysis; Gene expression; Genetic aspects; Genomes; Homeostasis; HT29 Cells; Human health and pathology; Humans; Immune response; Immune system; Immunomodulation; Inflammation; Intestines - cytology; Lactobacilli; Lactobacillus; Lactobacillus - physiology; Lactobacillus paracasei; Lactobacillus plantarum; Lactobacillus rhamnosus; Lactobacillus rhamnosus - physiology; Life Sciences; Lipid metabolism; Lipids; Lymphoid tissue; Medical treatment; Metabolic disorders; Metabolism; Mice; Mice, Inbred C57BL; Microbiota; Modulation; Obesity; Pathways; Peroxisome proliferator-activated receptors; Physiological aspects; Physiology; Probiotics; Proteins; Rodents; Small intestine; Strains (organisms); Target recognition; France; Canada; United States > US; TRIGLYCERIDE; BACTERIA; INHIBITION; PROTEIN; LINOLEIC-ACID; HYPERLIPIDEMIA; ANGIOPOIETIN-LIKE 4; TARGET GENE; LIPOPROTEIN-LIPASE; INDUCED OBESE MICE

Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of energy homeostasis. Lactobacilli are often considered to display beneficial effect for their hosts, acting on different regulatory pathways. The a...