Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice
Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of energy homeostasis. Lactobacilli are often considered to display beneficial effect for their hosts, acting on different regulatory pathways. The a...
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| Published in | PloS one Vol. 10; no. 10; p. e0138880 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Public Library of Science
06.10.2015
Public Library of Science (PLoS) |
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| Abstract | Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of energy homeostasis. Lactobacilli are often considered to display beneficial effect for their hosts, acting on different regulatory pathways. The aim of the present work was to study the effect of several lactobacilli strains on Fiaf gene expression in human intestinal epithelial cells (IECs) and on mice tissues to decipher the underlying mechanisms.
Nineteen lactobacilli strains have been tested on HT-29 human intestinal epithelial cells for their ability to regulate Fiaf gene expression by RT-qPCR. In order to determine regulated pathways, we analysed the whole genome transcriptome of IECs. We then validated in vivo bacterial effects using C57BL/6 mono-colonized mice fed with normal chow.
We identified one strain (Lactobacillus rhamnosus CNCMI-4317) that modulated Fiaf expression in IECs. This regulation relied potentially on bacterial surface-exposed molecules and seemed to be PPAR-γ independent but PPAR-α dependent. Transcriptome functional analysis revealed that multiple pathways including cellular function and maintenance, lymphoid tissue structure and development, as well as lipid metabolism were regulated by this strain. The regulation of immune system and lipid and carbohydrate metabolism was also confirmed by overrepresentation of Gene Ontology terms analysis. In vivo, circulating FIAF protein was increased by the strain but this phenomenon was not correlated with modulation Fiaf expression in tissues (except a trend in distal small intestine).
We showed that Lactobacillus rhamnosus CNCMI-4317 induced Fiaf expression in human IECs, and increased circulating FIAF protein level in mice. Moreover, this effect was accompanied by transcriptome modulation of several pathways including immune response and metabolism in vitro. |
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| AbstractList | Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of energy homeostasis. Lactobacilli are often considered to display beneficial effect for their hosts, acting on different regulatory pathways. The aim of the present work was to study the effect of several lactobacilli strains on Fiaf gene expression in human intestinal epithelial cells (IECs) and on mice tissues to decipher the underlying mechanisms.
Nineteen lactobacilli strains have been tested on HT-29 human intestinal epithelial cells for their ability to regulate Fiaf gene expression by RT-qPCR. In order to determine regulated pathways, we analysed the whole genome transcriptome of IECs. We then validated in vivo bacterial effects using C57BL/6 mono-colonized mice fed with normal chow.
We identified one strain (Lactobacillus rhamnosus CNCMI-4317) that modulated Fiaf expression in IECs. This regulation relied potentially on bacterial surface-exposed molecules and seemed to be PPAR-γ independent but PPAR-α dependent. Transcriptome functional analysis revealed that multiple pathways including cellular function and maintenance, lymphoid tissue structure and development, as well as lipid metabolism were regulated by this strain. The regulation of immune system and lipid and carbohydrate metabolism was also confirmed by overrepresentation of Gene Ontology terms analysis. In vivo, circulating FIAF protein was increased by the strain but this phenomenon was not correlated with modulation Fiaf expression in tissues (except a trend in distal small intestine).
We showed that Lactobacillus rhamnosus CNCMI-4317 induced Fiaf expression in human IECs, and increased circulating FIAF protein level in mice. Moreover, this effect was accompanied by transcriptome modulation of several pathways including immune response and metabolism in vitro. Background and Objectives Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of energy homeostasis. Lactobacilli are often considered to display beneficial effect for their hosts, acting on different regulatory pathways. The aim of the present work was to study the effect of several lactobacilli strains on Fiaf gene expression in human intestinal epithelial cells (IECs) and on mice tissues to decipher the underlying mechanisms. Subjects and Methods Nineteen lactobacilli strains have been tested on HT-29 human intestinal epithelial cells for their ability to regulate Fiaf gene expression by RT-qPCR. In order to determine regulated pathways, we analysed the whole genome transcriptome of IECs. We then validated in vivo bacterial effects using C57BL/6 mono-colonized mice fed with normal chow. Results We identified one strain (Lactobacillus rhamnosus CNCMI-4317) that modulated Fiaf expression in IECs. This regulation relied potentially on bacterial surface-exposed molecules and seemed to be PPAR-[gamma] independent but PPAR-[alpha] dependent. Transcriptome functional analysis revealed that multiple pathways including cellular function and maintenance, lymphoid tissue structure and development, as well as lipid metabolism were regulated by this strain. The regulation of immune system and lipid and carbohydrate metabolism was also confirmed by overrepresentation of Gene Ontology terms analysis. In vivo, circulating FIAF protein was increased by the strain but this phenomenon was not correlated with modulation Fiaf expression in tissues (except a trend in distal small intestine). Conclusion We showed that Lactobacillus rhamnosus CNCMI-4317 induced Fiaf expression in human IECs, and increased circulating FIAF protein level in mice. Moreover, this effect was accompanied by transcriptome modulation of several pathways including immune response and metabolism in vitro. Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of energy homeostasis. Lactobacilli are often considered to display beneficial effect for their hosts, acting on different regulatory pathways. The aim of the present work was to study the effect of several lactobacilli strains on Fiaf gene expression in human intestinal epithelial cells (IECs) and on mice tissues to decipher the underlying mechanisms. Nineteen lactobacilli strains have been tested on HT-29 human intestinal epithelial cells for their ability to regulate Fiaf gene expression by RT-qPCR. In order to determine regulated pathways, we analysed the whole genome transcriptome of IECs. We then validated in vivo bacterial effects using C57BL/6 mono-colonized mice fed with normal chow. We identified one strain (Lactobacillus rhamnosus CNCMI-4317) that modulated Fiaf expression in IECs. This regulation relied potentially on bacterial surface-exposed molecules and seemed to be PPAR-[gamma] independent but PPAR-[alpha] dependent. Transcriptome functional analysis revealed that multiple pathways including cellular function and maintenance, lymphoid tissue structure and development, as well as lipid metabolism were regulated by this strain. The regulation of immune system and lipid and carbohydrate metabolism was also confirmed by overrepresentation of Gene Ontology terms analysis. In vivo, circulating FIAF protein was increased by the strain but this phenomenon was not correlated with modulation Fiaf expression in tissues (except a trend in distal small intestine). We showed that Lactobacillus rhamnosus CNCMI-4317 induced Fiaf expression in human IECs, and increased circulating FIAF protein level in mice. Moreover, this effect was accompanied by transcriptome modulation of several pathways including immune response and metabolism in vitro. Background and Objectives Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of energy homeostasis. Lactobacilli are often considered to display beneficial effect for their hosts, acting on different regulatory pathways. The aim of the present work was to study the effect of several lactobacilli strains on Fiaf gene expression in human intestinal epithelial cells (IECs) and on mice tissues to decipher the underlying mechanisms. Subjects and Methods Nineteen lactobacilli strains have been tested on HT–29 human intestinal epithelial cells for their ability to regulate Fiaf gene expression by RT-qPCR. In order to determine regulated pathways, we analysed the whole genome transcriptome of IECs. We then validated in vivo bacterial effects using C57BL/6 mono-colonized mice fed with normal chow. Results We identified one strain ( Lactobacillus rhamnosus CNCMI–4317) that modulated Fiaf expression in IECs. This regulation relied potentially on bacterial surface-exposed molecules and seemed to be PPAR-γ independent but PPAR-α dependent. Transcriptome functional analysis revealed that multiple pathways including cellular function and maintenance, lymphoid tissue structure and development, as well as lipid metabolism were regulated by this strain. The regulation of immune system and lipid and carbohydrate metabolism was also confirmed by overrepresentation of Gene Ontology terms analysis. In vivo , circulating FIAF protein was increased by the strain but this phenomenon was not correlated with modulation Fiaf expression in tissues (except a trend in distal small intestine). Conclusion We showed that Lactobacillus rhamnosus CNCMI–4317 induced Fiaf expression in human IECs, and increased circulating FIAF protein level in mice. Moreover, this effect was accompanied by transcriptome modulation of several pathways including immune response and metabolism in vitro . Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of energy homeostasis. Lactobacilli are often considered to display beneficial effect for their hosts, acting on different regulatory pathways. The aim of the present work was to study the effect of several lactobacilli strains on Fiaf gene expression in human intestinal epithelial cells (IECs) and on mice tissues to decipher the underlying mechanisms.Nineteen lactobacilli strains have been tested on HT-29 human intestinal epithelial cells for their ability to regulate Fiaf gene expression by RT-qPCR. In order to determine regulated pathways, we analysed the whole genome transcriptome of IECs. We then validated in vivo bacterial effects using C57BL/6 mono-colonized mice fed with normal chow.We identified one strain (Lactobacillus rhamnosus CNCMI-4317) that modulated Fiaf expression in IECs. This regulation relied potentially on bacterial surface-exposed molecules and seemed to be PPAR-γ independent but PPAR-α dependent. Transcriptome functional analysis revealed that multiple pathways including cellular function and maintenance, lymphoid tissue structure and development, as well as lipid metabolism were regulated by this strain. The regulation of immune system and lipid and carbohydrate metabolism was also confirmed by overrepresentation of Gene Ontology terms analysis. In vivo, circulating FIAF protein was increased by the strain but this phenomenon was not correlated with modulation Fiaf expression in tissues (except a trend in distal small intestine).We showed that Lactobacillus rhamnosus CNCMI-4317 induced Fiaf expression in human IECs, and increased circulating FIAF protein level in mice. Moreover, this effect was accompanied by transcriptome modulation of several pathways including immune response and metabolism in vitro. Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of energy homeostasis. Lactobacilli are often considered to display beneficial effect for their hosts, acting on different regulatory pathways. The aim of the present work was to study the effect of several lactobacilli strains on Fiaf gene expression in human intestinal epithelial cells (IECs) and on mice tissues to decipher the underlying mechanisms.BACKGROUND AND OBJECTIVESIdentification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of energy homeostasis. Lactobacilli are often considered to display beneficial effect for their hosts, acting on different regulatory pathways. The aim of the present work was to study the effect of several lactobacilli strains on Fiaf gene expression in human intestinal epithelial cells (IECs) and on mice tissues to decipher the underlying mechanisms.Nineteen lactobacilli strains have been tested on HT-29 human intestinal epithelial cells for their ability to regulate Fiaf gene expression by RT-qPCR. In order to determine regulated pathways, we analysed the whole genome transcriptome of IECs. We then validated in vivo bacterial effects using C57BL/6 mono-colonized mice fed with normal chow.SUBJECTS AND METHODSNineteen lactobacilli strains have been tested on HT-29 human intestinal epithelial cells for their ability to regulate Fiaf gene expression by RT-qPCR. In order to determine regulated pathways, we analysed the whole genome transcriptome of IECs. We then validated in vivo bacterial effects using C57BL/6 mono-colonized mice fed with normal chow.We identified one strain (Lactobacillus rhamnosus CNCMI-4317) that modulated Fiaf expression in IECs. This regulation relied potentially on bacterial surface-exposed molecules and seemed to be PPAR-γ independent but PPAR-α dependent. Transcriptome functional analysis revealed that multiple pathways including cellular function and maintenance, lymphoid tissue structure and development, as well as lipid metabolism were regulated by this strain. The regulation of immune system and lipid and carbohydrate metabolism was also confirmed by overrepresentation of Gene Ontology terms analysis. In vivo, circulating FIAF protein was increased by the strain but this phenomenon was not correlated with modulation Fiaf expression in tissues (except a trend in distal small intestine).RESULTSWe identified one strain (Lactobacillus rhamnosus CNCMI-4317) that modulated Fiaf expression in IECs. This regulation relied potentially on bacterial surface-exposed molecules and seemed to be PPAR-γ independent but PPAR-α dependent. Transcriptome functional analysis revealed that multiple pathways including cellular function and maintenance, lymphoid tissue structure and development, as well as lipid metabolism were regulated by this strain. The regulation of immune system and lipid and carbohydrate metabolism was also confirmed by overrepresentation of Gene Ontology terms analysis. In vivo, circulating FIAF protein was increased by the strain but this phenomenon was not correlated with modulation Fiaf expression in tissues (except a trend in distal small intestine).We showed that Lactobacillus rhamnosus CNCMI-4317 induced Fiaf expression in human IECs, and increased circulating FIAF protein level in mice. Moreover, this effect was accompanied by transcriptome modulation of several pathways including immune response and metabolism in vitro.CONCLUSIONWe showed that Lactobacillus rhamnosus CNCMI-4317 induced Fiaf expression in human IECs, and increased circulating FIAF protein level in mice. Moreover, this effect was accompanied by transcriptome modulation of several pathways including immune response and metabolism in vitro. Background and Objectives Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of energy homeostasis. Lactobacilli are often considered to display beneficial effect for their hosts, acting on different regulatory pathways. The aim of the present work was to study the effect of several lactobacilli strains on Fiaf gene expression in human intestinal epithelial cells (IECs) and on mice tissues to decipher the underlying mechanisms. Subjects and Methods Nineteen lactobacilli strains have been tested on HT–29 human intestinal epithelial cells for their ability to regulate Fiaf gene expression by RT-qPCR. In order to determine regulated pathways, we analysed the whole genome transcriptome of IECs. We then validated in vivo bacterial effects using C57BL/6 mono-colonized mice fed with normal chow. Results We identified one strain (Lactobacillus rhamnosus CNCMI–4317) that modulated Fiaf expression in IECs. This regulation relied potentially on bacterial surface-exposed molecules and seemed to be PPAR-γ independent but PPAR-α dependent. Transcriptome functional analysis revealed that multiple pathways including cellular function and maintenance, lymphoid tissue structure and development, as well as lipid metabolism were regulated by this strain. The regulation of immune system and lipid and carbohydrate metabolism was also confirmed by overrepresentation of Gene Ontology terms analysis. In vivo, circulating FIAF protein was increased by the strain but this phenomenon was not correlated with modulation Fiaf expression in tissues (except a trend in distal small intestine). Conclusion We showed that Lactobacillus rhamnosus CNCMI–4317 induced Fiaf expression in human IECs, and increased circulating FIAF protein level in mice. Moreover, this effect was accompanied by transcriptome modulation of several pathways including immune response and metabolism in vitro. Background and ObjectivesIdentification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of energy homeostasis. Lactobacilli are often considered to display beneficial effect for their hosts, acting on different regulatory pathways. The aim of the present work was to study the effect of several lactobacilli strains on Fiaf gene expression in human intestinal epithelial cells (IECs) and on mice tissues to decipher the underlying mechanisms.Subjects and MethodsNineteen lactobacilli strains have been tested on HT–29 human intestinal epithelial cells for their ability to regulate Fiaf gene expression by RT-qPCR. In order to determine regulated pathways, we analysed the whole genome transcriptome of IECs. We then validated in vivo bacterial effects using C57BL/6 mono-colonized mice fed with normal chow.ResultsWe identified one strain (Lactobacillus rhamnosus CNCMI–4317) that modulated Fiaf expression in IECs. This regulation relied potentially on bacterial surface-exposed molecules and seemed to be PPAR-γ independent but PPAR-α dependent. Transcriptome functional analysis revealed that multiple pathways including cellular function and maintenance, lymphoid tissue structure and development, as well as lipid metabolism were regulated by this strain. The regulation of immune system and lipid and carbohydrate metabolism was also confirmed by overrepresentation of Gene Ontology terms analysis. In vivo, circulating FIAF protein was increased by the strain but this phenomenon was not correlated with modulation Fiaf expression in tissues (except a trend in distal small intestine).ConclusionWe showed that Lactobacillus rhamnosus CNCMI–4317 induced Fiaf expression in human IECs, and increased circulating FIAF protein level in mice. Moreover, this effect was accompanied by transcriptome modulation of several pathways including immune response and metabolism in vitro. |
| Audience | Academic |
| Author | Jacouton, Elsa Lapaque, Nicolas Blottière, Hervé M Clément, Karine Doré, Joël Mach, Núria Cadiou, Julie Smokvina, Tamara van Hylckama Vlieg, Johan E. T. |
| AuthorAffiliation | 2 INRA, UMR 1319 Micalis, Jouy en Josas, France 7 ICAN, APHP, CNRH-Ile de France, Paris, France University of Guelph, Canada, CANADA 1 Danone Nutricia Research, Palaiseau, France 4 INRA, US 1367, Metagenopolis, Jouy en Josas, France 5 INSERM, U872, centre de recherche des Cordeliers, Paris, France 6 UPMC, Paris, France 3 AgroParistech, UMR Micalis, Jouy en Josas, France |
| AuthorAffiliation_xml | – name: 4 INRA, US 1367, Metagenopolis, Jouy en Josas, France – name: 6 UPMC, Paris, France – name: 7 ICAN, APHP, CNRH-Ile de France, Paris, France – name: University of Guelph, Canada, CANADA – name: 5 INSERM, U872, centre de recherche des Cordeliers, Paris, France – name: 1 Danone Nutricia Research, Palaiseau, France – name: 2 INRA, UMR 1319 Micalis, Jouy en Josas, France – name: 3 AgroParistech, UMR Micalis, Jouy en Josas, France |
| Author_xml | – sequence: 1 givenname: Elsa surname: Jacouton fullname: Jacouton, Elsa – sequence: 2 givenname: Núria surname: Mach fullname: Mach, Núria – sequence: 3 givenname: Julie surname: Cadiou fullname: Cadiou, Julie – sequence: 4 givenname: Nicolas surname: Lapaque fullname: Lapaque, Nicolas – sequence: 5 givenname: Karine surname: Clément fullname: Clément, Karine – sequence: 6 givenname: Joël surname: Doré fullname: Doré, Joël – sequence: 7 givenname: Johan E. T. surname: van Hylckama Vlieg fullname: van Hylckama Vlieg, Johan E. T. – sequence: 8 givenname: Tamara surname: Smokvina fullname: Smokvina, Tamara – sequence: 9 givenname: Hervé M surname: Blottière fullname: Blottière, Hervé M |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26439630$$D View this record in MEDLINE/PubMed https://hal.sorbonne-universite.fr/hal-01272988$$DView record in HAL |
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| Cites_doi | 10.1128/AEM.00336-14 10.1111/j.1365-2672.2007.03336.x 10.1016/j.cmet.2010.11.002 10.1074/jbc.M109.025452 10.1161/CIRCULATIONAHA.111.049072 10.1186/gb-2002-3-7-research0034 10.1128/MCB.20.14.5343-5349.2000 10.1038/nature03985 10.1186/1471-2350-12-89 10.1053/j.gastro.2006.11.022 10.1074/jbc.M807899200 10.1074/jbc.M111.294124 10.1152/ajpgi.00293.2012 10.1194/jlr.P015867 10.1016/j.bbalip.2006.05.007 10.1152/ajpendo.90491.2008 10.1073/pnas.0408452102 10.1073/pnas.0809919106 10.1161/ATVBAHA.108.176917 10.1161/ATVBAHA.107.151894 10.1074/jbc.M113.497602 10.1073/pnas.0407076101 10.1371/journal.pone.0013087 10.1074/jbc.M506519200 10.1074/jbc.M004029200 10.3164/jcbn.11-07 10.1002/hep.24479 10.1371/journal.pone.0034868 10.1194/jlr.C200010-JLR200 10.1074/jbc.M110.142018 10.1038/nature12506 10.1111/j.1462-2920.2011.02482.x |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2015 Public Library of Science 2015 Jacouton et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Attribution 2015 Jacouton et al 2015 Jacouton et al |
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| DOI | 10.1371/journal.pone.0138880 |
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| Keywords | TRIGLYCERIDE BACTERIA INHIBITION PROTEIN LINOLEIC-ACID HYPERLIPIDEMIA ANGIOPOIETIN-LIKE 4 TARGET GENE LIPOPROTEIN-LIPASE INDUCED OBESE MICE |
| Language | English |
| License | Attribution: http://creativecommons.org/licenses/by This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: This work has been funded in part by Danone Research EJ, TS and JvHV work for Danone Research, part of Danone Group. Danone is selling products that contain lactobacilli. There is the following patent relating to material pertinent to this article (LACTOBACILLUS RHAMNOSUS STRAIN FOR REGULATING LIPID METABOLISM - Application No: PCT/IB/2014/060841 - Publication No: WO/2014/170879). There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials. Conceived and designed the experiments: EJ NL JvHV JD TS HMB. Performed the experiments: EJ JC. Analyzed the data: EJ NM NL HMB. Contributed reagents/materials/analysis tools: KC. Wrote the paper: EJ NM TS HMB. |
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| References | F Bäckhed (ref17) 2004; 44 MJ Lafferty (ref5) 2013; 40 H Li (ref29) 2011; 3 K Yoshida (ref7) 2002; 11 L Lichtenstein (ref11) 2010; 6 S Kersten (ref27) 2000; 37 J Vandesompele (ref22) 2002; 3 PJ Talmud (ref8) 2008; 12 NE Gray (ref2) 2012; 11 K Honda (ref26) 2012; 2 JC Yoon (ref14) 2000; 14 EC Lee (ref4) 2009; 20 E Le Chatellier (ref13) 2013; 500 S Alex (ref16) 2013; 4 C Grootaert (ref18) 2011; 7 L Aronsson (ref21) 2010; 9 P van Baarlen (ref31) 2009; 7 L Macia (ref32) 2012; 4 S Schmidt (ref33) 2008; 5 F Yan (ref30) 2007; 2 MR Robciuc (ref10) 2011; 8 A Galaup (ref12) 2012; 1 SK Koliwad (ref15) 2009; 38 A Korecka (ref19) 2013; 11 K Kaddatz (ref28) 2010; 38 K Lee (ref25) 2007; 4 MC Smart-Halajko (ref9) 2011; 12 SE Calvano (ref23) 2005; 437 L Lichtenstein (ref3) 2007; 11 GW Tannock (ref20) 2014; 9 HY Lee (ref24) 2006; 7 S Mandard (ref1) 2006; 2 A Xu (ref6) 2005; 17 16807088 - Biochim Biophys Acta. 2006 Jul;1761(7):736-44 10862772 - J Biol Chem. 2000 Sep 15;275(37):28488-93 22086875 - Circulation. 2012 Jan 3;125(1):140-9 22267746 - J Biol Chem. 2012 Mar 9;287(11):8444-56 12184808 - Genome Biol. 2002 Jun 18;3(7):RESEARCH0034 17258729 - Gastroenterology. 2007 Feb;132(2):562-75 15505215 - Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23 10866690 - Mol Cell Biol. 2000 Jul;20(14):5343-9 22962525 - J Clin Biochem Nutr. 2012 Sep;51(2):96-101 23518684 - Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1;304(11):G1025-37 19628874 - J Biol Chem. 2009 Sep 18;284(38):25593-601 23960078 - J Biol Chem. 2013 Oct 4;288(40):28524-34 17761937 - Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2420-7 18974381 - Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2319-25 18780771 - Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1084-94 21596930 - J Lipid Res. 2011 Aug;52(8):1575-82 20927337 - PLoS One. 2010;5(9). pii: e13087. doi: 10.1371/journal.pone.0013087 20595396 - J Biol Chem. 2010 Sep 17;285(38):29469-79 24141811 - Histochem Cell Biol. 2014 Apr;141(4):383-91 23985870 - Nature. 2013 Aug 29;500(7464):541-6 22514681 - PLoS One. 2012;7(4):e34868 21518214 - Environ Microbiol. 2011 Jul;13(7):1778-89 16136080 - Nature. 2005 Oct 13;437(7061):1032-7 17897219 - J Appl Microbiol. 2007 Oct;103(4):1140-6 21674552 - Hepatology. 2011 Sep 2;54(3):910-9 12401877 - J Lipid Res. 2002 Nov;43(11):1770-2 15837923 - Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6086-91 19190178 - Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2371-6 24584241 - Appl Environ Microbiol. 2014 May;80(9):2851-9 21714923 - BMC Med Genet. 2011;12:89 16272564 - J Biol Chem. 2006 Jan 13;281(2):934-44 19318355 - J Biol Chem. 2009 May 15;284(20):13735-45 21109191 - Cell Metab. 2010 Dec 1;12(6):580-92 |
| References_xml | – volume: 9 start-page: 2851 year: 2014 ident: ref20 article-title: Altered transcription of murine genes induced in the small bowel by administration of probiotic strain Lactobacillus rhamnosus HN001 publication-title: Appl Environ Microbiol doi: 10.1128/AEM.00336-14 – volume: 4 start-page: 1140 year: 2007 ident: ref25 article-title: Antiobesity effect of trans–10,cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet-induced obese mice publication-title: J Appl Microbiol doi: 10.1111/j.1365-2672.2007.03336.x – volume: 6 start-page: 580 year: 2010 ident: ref11 article-title: Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages publication-title: Cell Metab doi: 10.1016/j.cmet.2010.11.002 – volume: 38 start-page: 25593 year: 2009 ident: ref15 article-title: Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism publication-title: J Biol Chem doi: 10.1074/jbc.M109.025452 – volume: 1 start-page: 140 year: 2012 ident: ref12 article-title: Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.111.049072 – volume: 3 start-page: RESEARCH0034 year: 2002 ident: ref22 article-title: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes publication-title: Genome Biol doi: 10.1186/gb-2002-3-7-research0034 – volume: 14 start-page: 5343 year: 2000 ident: ref14 article-title: Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation publication-title: Mol Cell Biol doi: 10.1128/MCB.20.14.5343-5349.2000 – volume: 437 start-page: 1032 year: 2005 ident: ref23 article-title: A network-based analysis of systemic inflammation in humans publication-title: Nature doi: 10.1038/nature03985 – volume: 12 start-page: 89 year: 2011 ident: ref9 article-title: ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial publication-title: BMC Med Genet doi: 10.1186/1471-2350-12-89 – volume: 2 start-page: 562 year: 2007 ident: ref30 article-title: Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth publication-title: Gastroenterol doi: 10.1053/j.gastro.2006.11.022 – volume: 20 start-page: 13735 year: 2009 ident: ref4 article-title: Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL) publication-title: J Biol Chem doi: 10.1074/jbc.M807899200 – volume: 11 start-page: 8444 year: 2012 ident: ref2 article-title: Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes publication-title: J Biol Chem doi: 10.1074/jbc.M111.294124 – volume: 11 start-page: G1025 year: 2013 ident: ref19 article-title: ANGPTL4 expression induced by butyrate and rosiglitazone in human intestinal epithelial cells utilizes independent pathways publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00293.2012 – volume: 8 start-page: 1575 year: 2011 ident: ref10 article-title: Serum angiopoietin-like 4 protein levels and expression in adipose tissue are inversely correlated with obesity in monozygotic twins publication-title: J Lipid Res doi: 10.1194/jlr.P015867 – volume: 4 start-page: 383 year: 2013 ident: ref16 article-title: ANGPTL4 is produced by entero-endocrine cells in the human intestinal tract publication-title: Histochem Cell Biol – volume: 7 start-page: 736 year: 2006 ident: ref24 article-title: Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice publication-title: Biochim Biophys Acta doi: 10.1016/j.bbalip.2006.05.007 – volume: 5 start-page: 1084 year: 2008 ident: ref33 article-title: Neuronal functions, feeding behavior, and energy balance in Slc2a3+/- mice publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.90491.2008 – volume: 17 start-page: 6086 year: 2005 ident: ref6 article-title: Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0408452102 – volume: 7 start-page: 2371 year: 2009 ident: ref31 article-title: Differential NF-κB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0809919106 – volume: 12 start-page: 2319 year: 2008 ident: ref8 article-title: ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.108.176917 – volume: 11 start-page: 2420 year: 2007 ident: ref3 article-title: Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.107.151894 – volume: 40 start-page: 28524 year: 2013 ident: ref5 article-title: Angiopoietin-like protein 4 inhibition of lipoprotein lipase: evidence for reversible complex formation publication-title: J Biol Chem doi: 10.1074/jbc.M113.497602 – volume: 44 start-page: 15718 year: 2004 ident: ref17 article-title: The gut microbiota as an environmental factor that regulates fat storage publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0407076101 – volume: 9 start-page: e13087 year: 2010 ident: ref21 article-title: Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4) publication-title: PLoS One doi: 10.1371/journal.pone.0013087 – volume: 2 start-page: 934 year: 2006 ident: ref1 article-title: The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity publication-title: J Biol Chem doi: 10.1074/jbc.M506519200 – volume: 37 start-page: 28488 year: 2000 ident: ref27 article-title: Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene publication-title: J Biol Chem doi: 10.1074/jbc.M004029200 – volume: 2 start-page: 96 year: 2012 ident: ref26 article-title: Anti-diabetic effects of lactic acid bacteria in normal and type 2 diabetic mice publication-title: J Clin Biochem Nutr doi: 10.3164/jcbn.11-07 – volume: 3 start-page: 910 year: 2011 ident: ref29 article-title: Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule–1/integrin beta1 signaling in human hepatocellular carcinoma publication-title: Hepatology doi: 10.1002/hep.24479 – volume: 4 start-page: e34868 year: 2012 ident: ref32 article-title: Macrophage inhibitory cytokine 1 (MIC–1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets publication-title: PLoS One doi: 10.1371/journal.pone.0034868 – volume: 11 start-page: 1770 year: 2002 ident: ref7 article-title: Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase publication-title: J Lipid Res doi: 10.1194/jlr.C200010-JLR200 – volume: 38 start-page: 29469 year: 2010 ident: ref28 article-title: Transcriptional profiling identifies functional interactions of TGF beta and PPAR beta/delta signaling: synergistic induction of ANGPTL4 transcription publication-title: J Biol Chem doi: 10.1074/jbc.M110.142018 – volume: 500 start-page: 541 year: 2013 ident: ref13 article-title: Richness of human gut microbiome correlates with metabolic markers publication-title: Nature doi: 10.1038/nature12506 – volume: 7 start-page: 1778 year: 2011 ident: ref18 article-title: Bacterial monocultures, propionate, butyrate and H2O2 modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines publication-title: Environ Microbiol doi: 10.1111/j.1462-2920.2011.02482.x – reference: 19628874 - J Biol Chem. 2009 Sep 18;284(38):25593-601 – reference: 20927337 - PLoS One. 2010;5(9). pii: e13087. doi: 10.1371/journal.pone.0013087 – reference: 20595396 - J Biol Chem. 2010 Sep 17;285(38):29469-79 – reference: 21109191 - Cell Metab. 2010 Dec 1;12(6):580-92 – reference: 17897219 - J Appl Microbiol. 2007 Oct;103(4):1140-6 – reference: 21596930 - J Lipid Res. 2011 Aug;52(8):1575-82 – reference: 24141811 - Histochem Cell Biol. 2014 Apr;141(4):383-91 – reference: 16807088 - Biochim Biophys Acta. 2006 Jul;1761(7):736-44 – reference: 23985870 - Nature. 2013 Aug 29;500(7464):541-6 – reference: 15505215 - Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23 – reference: 19190178 - Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2371-6 – reference: 10862772 - J Biol Chem. 2000 Sep 15;275(37):28488-93 – reference: 21518214 - Environ Microbiol. 2011 Jul;13(7):1778-89 – reference: 17258729 - Gastroenterology. 2007 Feb;132(2):562-75 – reference: 22514681 - PLoS One. 2012;7(4):e34868 – reference: 16272564 - J Biol Chem. 2006 Jan 13;281(2):934-44 – reference: 22962525 - J Clin Biochem Nutr. 2012 Sep;51(2):96-101 – reference: 18780771 - Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1084-94 – reference: 22267746 - J Biol Chem. 2012 Mar 9;287(11):8444-56 – reference: 21674552 - Hepatology. 2011 Sep 2;54(3):910-9 – reference: 23960078 - J Biol Chem. 2013 Oct 4;288(40):28524-34 – reference: 24584241 - Appl Environ Microbiol. 2014 May;80(9):2851-9 – reference: 23518684 - Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1;304(11):G1025-37 – reference: 21714923 - BMC Med Genet. 2011;12:89 – reference: 18974381 - Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2319-25 – reference: 19318355 - J Biol Chem. 2009 May 15;284(20):13735-45 – reference: 15837923 - Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6086-91 – reference: 16136080 - Nature. 2005 Oct 13;437(7061):1032-7 – reference: 17761937 - Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2420-7 – reference: 12184808 - Genome Biol. 2002 Jun 18;3(7):RESEARCH0034 – reference: 22086875 - Circulation. 2012 Jan 3;125(1):140-9 – reference: 10866690 - Mol Cell Biol. 2000 Jul;20(14):5343-9 – reference: 12401877 - J Lipid Res. 2002 Nov;43(11):1770-2 |
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| Snippet | Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of... Background and Objectives Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a... Background and ObjectivesIdentification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a... Background and Objectives Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a... |
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| SubjectTerms | Angiopoietin-like 4 Protein Angiopoietins - genetics Angiopoietins - metabolism Animal tissues Animals Antibiotics Bacteria Bacterial effects Carbohydrate metabolism Carbohydrates Cellular structure Diabetes Diet Endocrinology and metabolism Energy balance Epithelial cells Epithelial Cells - metabolism Fatty acids Food and Nutrition Functional analysis Gene expression Genetic aspects Genomes Homeostasis HT29 Cells Human health and pathology Humans Immune response Immune system Immunomodulation Inflammation Intestines - cytology Lactobacilli Lactobacillus Lactobacillus - physiology Lactobacillus paracasei Lactobacillus plantarum Lactobacillus rhamnosus Lactobacillus rhamnosus - physiology Life Sciences Lipid metabolism Lipids Lymphoid tissue Medical treatment Metabolic disorders Metabolism Mice Mice, Inbred C57BL Microbiota Modulation Obesity Pathways Peroxisome proliferator-activated receptors Physiological aspects Physiology Probiotics Proteins Rodents Small intestine Strains (organisms) Target recognition |
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| Title | Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice |
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