Susceptibility Pattern of Enterococci at Tertiary Care Hospital

The study was aimed to characterize enterococci from various clinical specimens, to determine the antimicrobial susceptibility pattern, and to explore the association between virulence factors and antimicrobial resistance. A total of 283 clinical enterococcal isolates were speciated and subjected to...

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Published inJournal of global infectious diseases Vol. 9; no. 2; pp. 73 - 75
Main Authors Sachan, Sadhana, Rawat, Vinita, Umesh, Kumar, Mukesh, Kaur, Tripta, Chaturvedi, Preeti
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.04.2017
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Antibacterial agents
Antimicrobial agents
Biofilms
Care and treatment
Dosage and administration
Drug resistance
Enterococcal infections
Enterococcus
Gentamicins
Hospitals
Laboratories
Microbiology Report
Nosocomial infections
Urine
vancomycin resistant
virulence factors
Enterococcus
vancomycin resistant
virulence factors
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Summary:The study was aimed to characterize enterococci from various clinical specimens, to determine the antimicrobial susceptibility pattern, and to explore the association between virulence factors and antimicrobial resistance. A total of 283 clinical enterococcal isolates were speciated and subjected to antimicrobial susceptibility testing. Virulence factors (hemolysin, gelatinase, and biofilm production) were detected phenotypically. Of the 283 enterococci isolated, 12 species were identified; predominant species were (82.33%). High-level gentamicin (HLG) and vancomycin resistance were observed among 55.57% and 6.01% of enteroccal isolates, respectively. All vancomycin-resistant enterococci (VREs) were and had VanA phenotype and genotype. Hemolysin, gelatinase, and biofilm production were seen in 15.90%, 12.36%, and 13.43% of enterococcal isolates, respectively. Vancomycin and HLG resistance were observed in 0.35% and 61.86% of the enterococcal isolates producing virulence factors. Isolates resistant to HLG but susceptible to vancomycin expressed more virulent factors. Further research is required to reveal the complex interplay between drug resistance and virulence factors.
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ISSN:0974-777X
0974-8245
DOI:10.4103/0974-777X.194371