Spiking Pandemic Potential: Structural and Immunological Aspects of SARS-CoV-2

• Published in: Trends in microbiology (Regular ed.) Vol. 28; no. 8; pp. 605 - 618
• Main Authors: Wang, Ying-Ting, Landeras-Bueno, Sara, Hsieh, Li-En, Terada, Yutaka, Kim, Kenneth, Ley, Klaus, Shresta, Sujan, Saphire, Erica Ollmann, Regla-Nava, Jose Angel
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2020; Elsevier Science Ltd; The Authors. Published by Elsevier Ltd
• Subjects: Animal models; Animals; Betacoronavirus - chemistry; Betacoronavirus - immunology; coronavirus; Coronavirus Infections - epidemiology; Coronavirus Infections - prevention & control; Coronavirus Infections - therapy; Coronavirus Infections - virology; Coronaviruses; COVID-19; COVID-19 infection; Disease Models, Animal; Drug development; Epidemics; Epidemiology; host immune response; Humans; Immune response; Immunology; Innate immunity; microbiology; Outbreaks; pandemic; Pandemics; Pandemics - prevention & control; Pneumonia, Viral - epidemiology; Pneumonia, Viral - prevention & control; Pneumonia, Viral - therapy; Pneumonia, Viral - virology; Public health; Respiratory diseases; respiratory tract diseases; Review; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; spike; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - immunology; Spike protein; therapeutics; travel; Viral diseases; World Health Organization; COVID-19; host immune response; coronavirus; SARS-CoV-2; pandemic; spike

SARS-Coronavirus-2 (SARS-CoV-2) causes Coronavirus disease 2019 (COVID-19), an infectious respiratory disease causing thousands of deaths and overwhelming public health systems. The international spread of SARS-CoV-2 is associated with the ease of global travel, and societal dynamics, immunologic na...