Diarrhea During COVID-19 Infection: Pathogenesis, Epidemiology, Prevention, and Management

• Published in: Clinical gastroenterology and hepatology Vol. 18; no. 8; pp. 1663 - 1672
• Main Authors: D’Amico, Ferdinando, Baumgart, Daniel C., Danese, Silvio, Peyrin-Biroulet, Laurent
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2020; WB Saunders; by the AGA Institute
• Subjects: ACE2; Angiotensin-Converting Enzyme 2; Betacoronavirus - isolation & purification; Child; Coronavirus Infections - complications; COVID-19; Diarrhea; Diarrhea - epidemiology; Diarrhea - pathology; Diarrhea - physiopathology; Diarrhea - therapy; Disease Management; Disease Transmission, Infectious - prevention & control; Epidemiology; Feces - virology; Gastroenterology and Hepatology; Humans; Incidence; Infection Control - methods; Life Sciences; Pandemics; Peptidyl-Dipeptidase A - metabolism; Pneumonia, Viral - complications; SARS-CoV-2; Serine Endopeptidases - metabolism; Spike Glycoprotein, Coronavirus - metabolism; TMPRSS2; Virus Attachment; Virus Internalization; COVID-19; Angiotensin-Converting Enzyme 2; ACE2; SARS-CoV-2; SARS-CoV; Diarrhea; TMPRSS2; Epidemiology; MERS; Middle East respiratory syndrome; severe acute respiratory syndrome coronavirus; severe acute respiratory syndrome coronavirus 2; coronavirus disease 2019

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19) pandemic is a worldwide emergency. An increasing number of diarrhea cases is reported. Here we investigate the epidemiology, clinical presentation, molecular mechanisms, management, and prevention of SARS-CoV-2 associated diar...