Fusarielin A as an Anti-angiogenic and Anti-proliferative Agent: Basic Biological Characterization

• Published in: Chemical & Pharmaceutical Bulletin Vol. 56; no. 3; pp. 298 - 304
• Main Authors: Fujimoto, Haruka, Aoyama, Hiroshi, Noguchi-Yachide, Tomomi, Hashimoto, Yuichi, Kobayashi, Hisayoshi
• Format: Journal Article
• Language: English; Japanese
• Published: TOKYO The Pharmaceutical Society of Japan 01.03.2008; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan
• Subjects: Angiogenesis Inhibitors; anti-angiogenic activity; Antineoplastic Agents; Aspergillus oryzae - drug effects; binding protein; Cell Proliferation - drug effects; Cells, Cultured; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Coumarins - chemistry; Epoxy Compounds - chemical synthesis; Epoxy Compounds - metabolism; Epoxy Compounds - pharmacology; Fluorescent Dyes; fusarielin A; HL-60; HL-60 Cells; human umbilical vein endothelial cell; Humans; Indicators and Reagents; Isotope Labeling; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Naphthalenes - chemical synthesis; Naphthalenes - metabolism; Naphthalenes - pharmacology; Pharmacology & Pharmacy; Photoaffinity Labels; Physical Sciences; Science & Technology; Spores, Fungal - drug effects; Structure-Activity Relationship; tritium-labeling; DESIGN; ICM0301S; ASPERGILLUS SP F-1491; tritium-labeling; BINDING-PROTEIN; fusarielin A; binding protein; PROBES; PHYSICOCHEMICAL PROPERTIES; FLUORESCENT; human umbilical vein endothelial cell; anti-angiogenic activity; RHIZOXIN; HL-60; INHIBITORS
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.56.298

Fusarielin A shows anti-angiogenic activity in the human umbilical vein endothelial cell (HUVEC) tube formation assay. Structural development studies indicated the importance of the hydroxyl groups in this molecule. A 3H-labeled derivative and a fluorescent affinity-labeling agent were prepared and used to examine the cellular distribution and biological behavior of fusarielin A.