Lipid metabolism reprogramming and its potential targets in cancer

• Published in: Cancer communications (London, England) Vol. 38; no. 1; pp. 1 - 14
• Main Authors: Cheng, Chunming, Geng, Feng, Cheng, Xiang, Guo, Deliang
• Format: Journal Article
• Language: English
• Published: London BioMed Central 21.05.2018; Wiley
• Subjects: Animals; Antineoplastic Agents - therapeutic use; Cancer; Cholesterol; Endoplasmic Reticulum - metabolism; Fatty acids; Humans; Intracellular Signaling Peptides and Proteins - metabolism; Lipid droplets; Lipid metabolism; Lipid Metabolism - drug effects; Lipogenesis - drug effects; Membrane Proteins - metabolism; Models, Biological; Neoplasms - drug therapy; Neoplasms - metabolism; Review; SCAP; SREBPs; Sterol Regulatory Element Binding Proteins - metabolism; Lipid droplets; SCAP; SREBPs; Lipid metabolism; Fatty acids; Cholesterol; Cancer

Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy. Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth. Lipids constitute the basic structure of membranes and also function as signaling molecules and energy s...