Further reductions in nonvertebral fracture rate with long-term denosumab treatment in the FREEDOM open-label extension and influence of hip bone mineral density after 3 years

• Published in: Osteoporosis international Vol. 26; no. 12; pp. 2763 - 2771
• Main Authors: Ferrari, S., Adachi, J. D., Lippuner, K., Zapalowski, C., Miller, P. D., Reginster, J.-Y., Törring, O., Kendler, D. L., Daizadeh, N. S., Wang, A., O’Malley, C. D., Wagman, R. B., Libanati, C., Lewiecki, E. M.
• Format: Journal Article Web Resource
• Language: English
• Published: London Springer London 01.12.2015; Springer Nature B.V; Springer Science & Business Media B.V
• Subjects: Aged; Aged, 80 and over; Bone density; Bone Density - drug effects; Bone Density Conservation Agents - administration & dosage; Bone Density Conservation Agents - therapeutic use; denosumab; Denosumab - administration & dosage; Denosumab - therapeutic use; Double-Blind Method; Drug Administration Schedule; Drug therapy; Endocrinology; Female; Follow-Up Studies; fracture treshold; Fractures; General & internal medicine; hip bone mineral density; Hip Joint - physiopathology; Human health sciences; Humans; Incidence; long-term osteoporosis therapy; Medicine; Medicine & Public Health; Middle Aged; Médecine générale & interne; nonvertebral fracture; Original; Original Article; Orthopedics; Osteoporosis; Osteoporosis, Postmenopausal - drug therapy; Osteoporosis, Postmenopausal - epidemiology; Osteoporosis, Postmenopausal - physiopathology; Osteoporotic Fractures - epidemiology; Osteoporotic Fractures - physiopathology; Osteoporotic Fractures - prevention & control; Rheumatology; Sciences de la santé humaine; treatment to goal; Hip bone mineral density; Long-term osteoporosis therapy; Fracture threshold; Nonvertebral fracture; Denosumab; Treatment to goal

Summary Limited data exist on the efficacy of long-term therapies for osteoporosis. In osteoporotic postmenopausal women receiving denosumab for 7 years, nonvertebral fracture rates significantly decreased in years 4–7 versus years 1–3. This is the first demonstration of a further benefit on fractur...