Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression

• Published in: Journal of hepatology Vol. 66; no. 3; pp. 601 - 609
• Main Authors: Ramirez, Teresa, Li, Yong-Mei, Yin, Shi, Xu, Ming-Jiang, Feng, Dechun, Zhou, Zhou, Zang, Mengwei, Mukhopadhyay, Partha, Varga, Zoltan V., Pacher, Pal, Gao, Bin, Wang, Hua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2017; Elsevier Science Ltd
• Subjects: Aging; Aging - genetics; Aging - metabolism; Aging - pathology; Alcohol; Animals; Binge Drinking; c-Myc protein; Cell culture; Clonal deletion; Cystic fibrosis; Disease Models, Animal; Down-Regulation; Ethanol; Fatty liver; Female; Fibrosis; Gastroenterology and Hepatology; Hepatic stellate cells (HSCs); Hepatic Stellate Cells - metabolism; Hepatic Stellate Cells - pathology; Hepatocytes; Liver diseases; Liver Diseases, Alcoholic - etiology; Liver Diseases, Alcoholic - genetics; Liver Diseases, Alcoholic - pathology; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle-age; Myc protein; Oxidative Stress; PDGFR-α; SIRT1 protein; Sirtuin 1 - deficiency; Sirtuin 1 - genetics; Steatohepatitis; Stellate cells; Middle-age; Hepatic stellate cells (HSCs); Fatty liver; Ethanol; Steatohepatitis; PDGFR-α

[Display omitted] Aging is known to exacerbate the progression of alcoholic liver disease (ALD), but the underlying mechanisms remain obscure. The aim of this study was to use a chronic plus binge ethanol feeding model in mice to evaluate the effects of aging on alcohol-induced liver injury. C57BL/6...