Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression - Ramirez, Teresa; Li, Yong-Mei; Yin, Shi; Xu, Ming-Jiang; Feng, Dechun; Zhou, Zhou; Zang, Mengwei; Mukhopadhyay, Partha; Varga, Zoltan V.; Pacher, Pal; Gao, Bin; Wang, Hua (Journal of hepatology, 2017)
Keywords: Aging; Aging - genetics; Aging - metabolism; Aging - pathology; Alcohol; Animals; Binge Drinking; c-Myc protein; Cell culture; Clonal deletion; Cystic fibrosis; Disease Models, Animal; Down-Regulation; Ethanol; Fatty liver; Female; Fibrosis; Gastroenterology and Hepatology; Hepatic stellate cells (HSCs); Hepatic Stellate Cells - metabolism; Hepatic Stellate Cells - pathology; Hepatocytes; Liver diseases; Liver Diseases, Alcoholic - etiology; Liver Diseases, Alcoholic - genetics; Liver Diseases, Alcoholic - pathology; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle-age; Myc protein; Oxidative Stress; PDGFR-α; SIRT1 protein; Sirtuin 1 - deficiency; Sirtuin 1 - genetics; Steatohepatitis; Stellate cells; Middle-age; Hepatic stellate cells (HSCs); Fatty liver; Ethanol; Steatohepatitis; PDGFR-α