Evidence for Mechanisms Underlying the Functional Benefits of a Myocardial Matrix Hydrogel for Post-MI Treatment

• Published in: Journal of the American College of Cardiology Vol. 67; no. 9; pp. 1074 - 1086
• Main Authors: Wassenaar, Jean W., Gaetani, Roberto, Garcia, Julian J., Braden, Rebecca L., Luo, Colin G., Huang, Diane, DeMaria, Anthony N., Omens, Jeffrey H., Christman, Karen L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.03.2016; Elsevier Limited
• Subjects: Animals; biomaterial; Biomedical materials; Cardiology; Cardiomyocytes; Cardiovascular; Coronary Circulation - physiology; Disease Models, Animal; Extracellular matrix; Extracellular Matrix - chemistry; Female; Gene expression; Heart attacks; heart failure; Heart Failure - etiology; Heart Failure - metabolism; Heart Failure - prevention & control; Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage; Hydrogels; infarction; Injections; Ischemia; Laboratory animals; Metabolism; microarray; Myocardial Infarction - complications; Myocardium; Neovascularization, Physiologic - drug effects; Principal components analysis; Rats; Rats, Sprague-Dawley; Rodents; Studies; Ventricular Remodeling - drug effects; United States > US; California; heart failure; biomaterial; IHC; infarction; LV; ECM; microarray; PPAR; CPC; qPCR; MI; extracellular matrix; HF; left ventricle; myocardial infarction; cardiac progenitor cell; immunohistochemistry; peroxisome proliferator-activated receptor; quantitative real-time polymerase chain reaction

There is increasing need for better therapies to prevent the development of heart failure after myocardial infarction (MI). An injectable hydrogel derived from decellularized porcine ventricular myocardium has been shown to halt the post-infarction progression of negative left ventricular remodeling...