Limitations of reliance on specific IgE for epidemiologic surveillance of food allergy

[...]in the extensive literature review conducted for development of the National Institute of Allergy and Infectious Diseases Guidelines for the Diagnosis and Management of Food Allergy, the authors could only conclude that food allergy affects more than 1% to 2% but <10% of the population.1 All...

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 130; no. 5; pp. 1207 - 1209.e10
Main Authors Keet, Corinne A., Wood, Robert A., Matsui, Elizabeth C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2012
Elsevier Limited
Subjects
Adolescent
Adult
Age
Aged
Aged, 80 and over
Allergens - immunology
Allergies
Allergy and Immunology
Arachis - immunology
Asthma
Child
Child, Preschool
Eggs
Epidemiological Monitoring
Epitopes - immunology
Female
Food
Food allergies
Food Hypersensitivity - epidemiology
Food Hypersensitivity - immunology
Humans
Immunoglobulin E - immunology
Indexing in process
Male
Middle Aged
Peanuts
Population
Predictive Value of Tests
Prevalence
Sex Factors
United States
Young Adult
United States
United States > US
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Summary:[...]in the extensive literature review conducted for development of the National Institute of Allergy and Infectious Diseases Guidelines for the Diagnosis and Management of Food Allergy, the authors could only conclude that food allergy affects more than 1% to 2% but <10% of the population.1 Allergen-specific IgE offers a potential surrogate. According to the cutoffs used by others,3 for each food we divided subjects into groups defined by food-specific IgE: "unlikely food allergy" (food-specific IgE of 0.35-2 kU/L), "probable food allergy" (food-specific IgE between 2 and 7 kU/L for egg, 15 kU/L for milk, 14 kU/L for peanut, and 5 kU/L for shrimp), and "likely food allergy" (food-specific IgE above those levels).
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ISSN:0091-6749
1097-6825
1097-6825
DOI:10.1016/j.jaci.2012.07.020