The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain

• Published in: Nature genetics Vol. 43; no. 7; pp. 706 - 711
• Main Authors: Gehman, Lauren T, Stoilov, Peter, Maguire, Jamie, Damianov, Andrey, Lin, Chia-Ho, Shiue, Lily, Ares, Manuel, Mody, Istvan, Black, Douglas L
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2011; Nature Publishing Group
• Subjects: 631/208/2489/144; 631/337/1645/1946; 692/699/375; Agriculture; Alternative Splicing; Animal Genetics and Genomics; Animals; Apoptosis; Binding proteins; Biological and medical sciences; Biomarkers - metabolism; Biomedical and Life Sciences; Biomedicine; Blotting, Western; Brain - cytology; Brain - metabolism; Cancer Research; Cell Proliferation; Central nervous system; Electrophysiology; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Profiling; Gene Expression Regulation; Gene Function; Genetic aspects; Genetics of eukaryotes. Biological and molecular evolution; Homeostasis; Human Genetics; Human subjects; Immunoenzyme Techniques; Kainic Acid - toxicity; letter; Male; Methods; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons - cytology; Neurons - metabolism; Oligonucleotide Array Sequence Analysis; Physiological aspects; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA splicing; RNA Splicing Factors; RNA, Messenger - genetics; RNA-Binding Proteins - physiology; Rodents; Seizures - chemically induced; Synaptic Transmission; United States; Vertebrata; Regulation(control); Mammalia; Neuron; Splicing; Central nervous system; Encephalon

The Rbfox family of RNA binding proteins mediate alternative splicing. Douglas Black and colleagues show that targeted deletion of the mouse Rbfox1 gene in the CNS alters splice isoforms of a subset of genes and is associated with neural hyperexcitability with spontaneous and drug-induced seizures....