Genetic Etiology for Alcohol-Induced Cardiac Toxicity

• Published in: Journal of the American College of Cardiology Vol. 71; no. 20; pp. 2293 - 2302
• Main Authors: Ware, James S., Amor-Salamanca, Almudena, Tayal, Upasana, Govind, Risha, Serrano, Isabel, Salazar-Mendiguchía, Joel, García-Pinilla, Jose Manuel, Pascual-Figal, Domingo A., Nuñez, Julio, Guzzo-Merello, Gonzalo, Gonzalez-Vioque, Emiliano, Bardaji, Alfredo, Manito, Nicolas, López-Garrido, Miguel A., Padron-Barthe, Laura, Edwards, Elizabeth, Whiffin, Nicola, Walsh, Roddy, Buchan, Rachel J., Midwinter, William, Wilk, Alicja, Prasad, Sanjay, Pantazis, Antonis, Baski, John, O’Regan, Declan P., Alonso-Pulpon, Luis, Cook, Stuart A., Lara-Pezzi, Enrique, Barton, Paul J., Garcia-Pavia, Pablo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.05.2018; Elsevier Limited; Elsevier Biomedical
• Subjects: Adult; Aged; alcohol; Alcohol use; Alcoholic beverages; Cardiology; Cardiomyopathy; Cardiomyopathy, Alcoholic - diagnosis; Cardiomyopathy, Alcoholic - etiology; Cardiomyopathy, Alcoholic - genetics; Cardiotoxicity - diagnosis; Cardiotoxicity - etiology; Cardiotoxicity - genetics; Cardiovascular; Cardiovascular disease; Cohort Studies; Connectin; Coronary vessels; Dilated cardiomyopathy; Ethnicity; Etiology; Family medical history; Female; Genetic Predisposition to Disease - etiology; Genetic Predisposition to Disease - genetics; Genetic screening; genetics; Genotype & phenotype; Genotypes; Heart; Heart diseases; Heart failure; Heart surgery; Humans; Male; Medical prognosis; Middle Aged; Multivariate analysis; Patients; Phenotypes; Prospective Studies; Recovery of function; Self Report; Survival analysis; titin; Toxicity; Transplants & implants; variant; Ventricle; alcohol; titin; genetics; ExAC; TTNtv; variant; LVEF; ACM; dilated cardiomyopathy; DCM; alcoholic cardiomyopathy; left ventricular ejection fraction; Exome Aggregation Consortium; titin truncating variant

Alcoholic cardiomyopathy (ACM) is defined by a dilated and impaired left ventricle due to chronic excess alcohol consumption. It is largely unknown which factors determine cardiac toxicity on exposure to alcohol. This study sought to evaluate the role of variation in cardiomyopathy-associated genes...