Microparticles in nasal lavage fluids in chronic rhinosinusitis: Potential biomarkers for diagnosis of aspirin-exacerbated respiratory disease - Takahashi, Toru; Kato, Atsushi; Berdnikovs, Sergejs; Stevens, Whitney W.; Suh, Lydia A.; Norton, James E.; Carter, Roderick G.; Harris, Kathleen E.; Peters, Anju T.; Hulse, Kathryn E.; Grammer, Leslie C.; Welch, Kevin C.; et al. (Journal of allergy and clinical immunology, 2017)
Keywords: Adult; Allergy and Immunology; Apoptosis; Aspirin; aspirin-exacerbated respiratory disease; Asthma; Asthma, Aspirin-Induced - pathology; basophil activation; Biomarkers; c-Kit protein; CD137; CD137 antigen; CD69; Cell activation; Cell adhesion & migration; Cell adhesion molecules; Cell injury; Cell-Derived Microparticles; Chronic Disease; chronic rhinosinusitis; Comorbidity; Diagnosis; Disease; E-cadherin; eosinophil activation; epithelial injury; Fc receptors; Female; Flow cytometry; Humans; Inflammation; Leukocytes (basophilic); Leukocytes (eosinophilic); Male; mast cell activation; Mast cells; Medical diagnosis; Membrane vesicles; Microparticles; Middle Aged; Mucin; Nasal Lavage Fluid - cytology; Nasal Polyps - pathology; Pathogenesis; Platelets; Polyps; Respiratory diseases; Rhinitis; Rhinitis - pathology; Rhinosinusitis; Sinusitis; Sinusitis - pathology; EpCAM; CRS; MCMPs; aspirin-exacerbated respiratory disease; AERD; apoptosis; CRSwNP; Microparticles; CRSsNP; AUC; NLFs; basophil activation; EoMPs; CD137; epithelial injury; mast cell activation; CFSE; EndoMPs; EpiMPs; ATA; MPs; eosinophil activation; PltMPs; chronic rhinosinusitis; CD69; BasoMPs; Aspirin-tolerant asthma; Epithelial cell adhesion molecule; Eosinophil MPs defined as EMR1(+)MPs; Area under the curve; Nasal lavage fluids; Basophil MPs defined as CD203c(+)c-kit(−)MPs; Endothelial MPs defined as CD31(+)CD41(−)MPs; Epithelial MPs defined as EpCAM(+)MPs or E-cadherin(+)MPs; Mast cell MPs defined as FcεRI(+)c-kit(+)MPs; Chronic rhinosinusitis without nasal polyps; Carboxyfluorescein succinimidyl ester; Chronic rhinosinusitis with nasal polyps; Platelet MPs defined as CD31(+)CD41(+)MPs