Effect of Aging on Human Mesenchymal Stem Cell Therapy in Ischemic Cardiomyopathy Patients
The role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial. This study sought to determine whether the therapeutic effect of culture-expanded MSCs persists, even in older subjects. Patients with ICM who received MSCs via transendo...
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| Published in | Journal of the American College of Cardiology Vol. 65; no. 2; pp. 125 - 132 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
20.01.2015
Elsevier Limited |
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| Online Access | Get full text |
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| Abstract | The role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial.
This study sought to determine whether the therapeutic effect of culture-expanded MSCs persists, even in older subjects.
Patients with ICM who received MSCs via transendocardial stem cell injection (TESI) as part of the TAC-HFT (Transendocardial Autologous Cells in Ischemic Heart Failure) (n = 19) and POSEIDON (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis) (n = 30) clinical trials were divided into 2 age groups: younger than 60 and 60 years of age and older. Functional capacity was measured by 6-min walk distance (6MWD) and quality of life using the Minnesota Living With Heart Failure Questionnaire (MLHFQ) score, measured at baseline, 6 months, and 1 year post-TESI. Various cardiac imaging parameters, including absolute scar size, were compared at baseline and 1 year post-TESI.
The mean 6MWD was similar at baseline and increased at 1 year post-TESI in both groups: 48.5 ± 14.6 m (p = 0.001) for the younger and 35.9 ± 18.3 m (p = 0.038) for the older participants (p = NS between groups). The older group exhibited a significant reduction in MLHFQ score (−7.04 ± 3.54; p = 0.022), whereas the younger than 60 age group had a borderline significant reduction (−11.22 ± 5.24; p = 0.058) from baseline (p = NS between groups). Although there were significant reductions in absolute scar size from baseline to 1 year post-TESI, the effect did not differ by age.
MSC therapy with TESI in ICM patients improves 6MWD and MLHFQ score and reduces myocardial infarction size. Importantly, older individuals did not have an impaired response to MSC therapy. |
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| AbstractList | The role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial.
This study sought to determine whether the therapeutic effect of culture-expanded MSCs persists, even in older subjects.
Patients with ICM who received MSCs via transendocardial stem cell injection (TESI) as part of the TAC-HFT (Transendocardial Autologous Cells in Ischemic Heart Failure) (n = 19) and POSEIDON (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis) (n = 30) clinical trials were divided into 2 age groups: younger than 60 and 60 years of age and older. Functional capacity was measured by 6-min walk distance (6MWD) and quality of life using the Minnesota Living With Heart Failure Questionnaire (MLHFQ) score, measured at baseline, 6 months, and 1 year post-TESI. Various cardiac imaging parameters, including absolute scar size, were compared at baseline and 1 year post-TESI.
The mean 6MWD was similar at baseline and increased at 1 year post-TESI in both groups: 48.5 ± 14.6 m (p = 0.001) for the younger and 35.9 ± 18.3 m (p = 0.038) for the older participants (p = NS between groups). The older group exhibited a significant reduction in MLHFQ score (-7.04 ± 3.54; p = 0.022), whereas the younger than 60 age group had a borderline significant reduction (-11.22 ± 5.24; p = 0.058) from baseline (p = NS between groups). Although there were significant reductions in absolute scar size from baseline to 1 year post-TESI, the effect did not differ by age.
MSC therapy with TESI in ICM patients improves 6MWD and MLHFQ score and reduces myocardial infarction size. Importantly, older individuals did not have an impaired response to MSC therapy. Background The role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial. Objectives This study sought to determine whether the therapeutic effect of culture-expanded MSCs persists, even in older subjects. Methods Patients with ICM who received MSCs via transendocardial stem cell injection (TESI) as part of the TAC-HFT (Transendocardial Autologous Cells in Ischemic Heart Failure) (n = 19) and POSEIDON (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis) (n = 30) clinical trials were divided into 2 age groups: younger than 60 and 60 years of age and older. Functional capacity was measured by 6-min walk distance (6MWD) and quality of life using the Minnesota Living With Heart Failure Questionnaire (MLHFQ) score, measured at baseline, 6 months, and 1 year post-TESI. Various cardiac imaging parameters, including absolute scar size, were compared at baseline and 1 year post-TESI. Results The mean 6MWD was similar at baseline and increased at 1 year post-TESI in both groups: 48.5 ± 14.6 m (p = 0.001) for the younger and 35.9 ± 18.3 m (p = 0.038) for the older participants (p = NS between groups). The older group exhibited a significant reduction in MLHFQ score (-7.04 ± 3.54; p = 0.022), whereas the younger than 60 age group had a borderline significant reduction (-11.22 ± 5.24; p = 0.058) from baseline (p = NS between groups). Although there were significant reductions in absolute scar size from baseline to 1 year post-TESI, the effect did not differ by age. Conclusions MSC therapy with TESI in ICM patients improves 6MWD and MLHFQ score and reduces myocardial infarction size. Importantly, older individuals did not have an impaired response to MSC therapy. The role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial.BACKGROUNDThe role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial.This study sought to determine whether the therapeutic effect of culture-expanded MSCs persists, even in older subjects.OBJECTIVESThis study sought to determine whether the therapeutic effect of culture-expanded MSCs persists, even in older subjects.Patients with ICM who received MSCs via transendocardial stem cell injection (TESI) as part of the TAC-HFT (Transendocardial Autologous Cells in Ischemic Heart Failure) (n = 19) and POSEIDON (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis) (n = 30) clinical trials were divided into 2 age groups: younger than 60 and 60 years of age and older. Functional capacity was measured by 6-min walk distance (6MWD) and quality of life using the Minnesota Living With Heart Failure Questionnaire (MLHFQ) score, measured at baseline, 6 months, and 1 year post-TESI. Various cardiac imaging parameters, including absolute scar size, were compared at baseline and 1 year post-TESI.METHODSPatients with ICM who received MSCs via transendocardial stem cell injection (TESI) as part of the TAC-HFT (Transendocardial Autologous Cells in Ischemic Heart Failure) (n = 19) and POSEIDON (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis) (n = 30) clinical trials were divided into 2 age groups: younger than 60 and 60 years of age and older. Functional capacity was measured by 6-min walk distance (6MWD) and quality of life using the Minnesota Living With Heart Failure Questionnaire (MLHFQ) score, measured at baseline, 6 months, and 1 year post-TESI. Various cardiac imaging parameters, including absolute scar size, were compared at baseline and 1 year post-TESI.The mean 6MWD was similar at baseline and increased at 1 year post-TESI in both groups: 48.5 ± 14.6 m (p = 0.001) for the younger and 35.9 ± 18.3 m (p = 0.038) for the older participants (p = NS between groups). The older group exhibited a significant reduction in MLHFQ score (-7.04 ± 3.54; p = 0.022), whereas the younger than 60 age group had a borderline significant reduction (-11.22 ± 5.24; p = 0.058) from baseline (p = NS between groups). Although there were significant reductions in absolute scar size from baseline to 1 year post-TESI, the effect did not differ by age.RESULTSThe mean 6MWD was similar at baseline and increased at 1 year post-TESI in both groups: 48.5 ± 14.6 m (p = 0.001) for the younger and 35.9 ± 18.3 m (p = 0.038) for the older participants (p = NS between groups). The older group exhibited a significant reduction in MLHFQ score (-7.04 ± 3.54; p = 0.022), whereas the younger than 60 age group had a borderline significant reduction (-11.22 ± 5.24; p = 0.058) from baseline (p = NS between groups). Although there were significant reductions in absolute scar size from baseline to 1 year post-TESI, the effect did not differ by age.MSC therapy with TESI in ICM patients improves 6MWD and MLHFQ score and reduces myocardial infarction size. Importantly, older individuals did not have an impaired response to MSC therapy.CONCLUSIONSMSC therapy with TESI in ICM patients improves 6MWD and MLHFQ score and reduces myocardial infarction size. Importantly, older individuals did not have an impaired response to MSC therapy. The role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial. This study sought to determine whether the therapeutic effect of culture-expanded MSCs persists, even in older subjects. Patients with ICM who received MSCs via transendocardial stem cell injection (TESI) as part of the TAC-HFT (Transendocardial Autologous Cells in Ischemic Heart Failure) (n = 19) and POSEIDON (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis) (n = 30) clinical trials were divided into 2 age groups: younger than 60 and 60 years of age and older. Functional capacity was measured by 6-min walk distance (6MWD) and quality of life using the Minnesota Living With Heart Failure Questionnaire (MLHFQ) score, measured at baseline, 6 months, and 1 year post-TESI. Various cardiac imaging parameters, including absolute scar size, were compared at baseline and 1 year post-TESI. The mean 6MWD was similar at baseline and increased at 1 year post-TESI in both groups: 48.5 ± 14.6 m (p = 0.001) for the younger and 35.9 ± 18.3 m (p = 0.038) for the older participants (p = NS between groups). The older group exhibited a significant reduction in MLHFQ score (−7.04 ± 3.54; p = 0.022), whereas the younger than 60 age group had a borderline significant reduction (−11.22 ± 5.24; p = 0.058) from baseline (p = NS between groups). Although there were significant reductions in absolute scar size from baseline to 1 year post-TESI, the effect did not differ by age. MSC therapy with TESI in ICM patients improves 6MWD and MLHFQ score and reduces myocardial infarction size. Importantly, older individuals did not have an impaired response to MSC therapy. AbstractBackgroundThe role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial. ObjectivesThis study sought to determine whether the therapeutic effect of culture-expanded MSCs persists, even in older subjects. MethodsPatients with ICM who received MSCs via transendocardial stem cell injection (TESI) as part of the TAC-HFT (Transendocardial Autologous Cells in Ischemic Heart Failure) (n = 19) and POSEIDON (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis) (n = 30) clinical trials were divided into 2 age groups: younger than 60 and 60 years of age and older. Functional capacity was measured by 6-min walk distance (6MWD) and quality of life using the Minnesota Living With Heart Failure Questionnaire (MLHFQ) score, measured at baseline, 6 months, and 1 year post-TESI. Various cardiac imaging parameters, including absolute scar size, were compared at baseline and 1 year post-TESI. ResultsThe mean 6MWD was similar at baseline and increased at 1 year post-TESI in both groups: 48.5 ± 14.6 m (p = 0.001) for the younger and 35.9 ± 18.3 m (p = 0.038) for the older participants (p = NS between groups). The older group exhibited a significant reduction in MLHFQ score (−7.04 ± 3.54; p = 0.022), whereas the younger than 60 age group had a borderline significant reduction (−11.22 ± 5.24; p = 0.058) from baseline (p = NS between groups). Although there were significant reductions in absolute scar size from baseline to 1 year post-TESI, the effect did not differ by age. ConclusionsMSC therapy with TESI in ICM patients improves 6MWD and MLHFQ score and reduces myocardial infarction size. Importantly, older individuals did not have an impaired response to MSC therapy. |
| Author | DiFede, Darcy L. Fishman, Joel E. Golpanian, Samuel El-Khorazaty, Jill Suncion, Viky Y. Mendizabal, Adam Karantalis, Vasileios Hare, Joshua M. Ghersin, Eduard Balkan, Wayne |
| AuthorAffiliation | Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida The EMMES Corporation, Rockville, Maryland |
| AuthorAffiliation_xml | – name: Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida – name: The EMMES Corporation, Rockville, Maryland – name: Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida |
| Author_xml | – sequence: 1 givenname: Samuel surname: Golpanian fullname: Golpanian, Samuel organization: Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida – sequence: 2 givenname: Jill surname: El-Khorazaty fullname: El-Khorazaty, Jill organization: EMMES Corporation, Rockville, Maryland – sequence: 3 givenname: Adam surname: Mendizabal fullname: Mendizabal, Adam organization: EMMES Corporation, Rockville, Maryland – sequence: 4 givenname: Darcy L. surname: DiFede fullname: DiFede, Darcy L. organization: Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida – sequence: 5 givenname: Viky Y. surname: Suncion fullname: Suncion, Viky Y. organization: Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida – sequence: 6 givenname: Vasileios surname: Karantalis fullname: Karantalis, Vasileios organization: Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida – sequence: 7 givenname: Joel E. surname: Fishman fullname: Fishman, Joel E. organization: Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida – sequence: 8 givenname: Eduard surname: Ghersin fullname: Ghersin, Eduard organization: Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida – sequence: 9 givenname: Wayne surname: Balkan fullname: Balkan, Wayne organization: Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida – sequence: 10 givenname: Joshua M. surname: Hare fullname: Hare, Joshua M. email: jhare@med.miami.edu organization: Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25593053$$D View this record in MEDLINE/PubMed |
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| Keywords | TESI heart failure EF hMSC CI ischemic heart disease ESV LV infarct size ICM MLHFQ EDV MI MSC 6MWD ejection fraction myocardial infarction end-diastolic volume left ventricular human mesenchymal stem cell mesenchymal stem cell 6-min walk distance end-systolic volume transendocardial stem cell injection ischemic cardiomyopathy confidence interval Minnesota Living With Heart Failure Questionnaire |
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| Snippet | The role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial.
This study sought to... AbstractBackgroundThe role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial.... Background The role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial. Objectives This... The role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial.BACKGROUNDThe role of patient... |
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| SubjectTerms | Adult Age Aging Cardiology Cardiomyopathy Cardiovascular Cardiovascular disease Cells, Cultured Clinical trials Confidence intervals Female Heart attacks Heart failure Hispanic Americans Humans infarct size ischemic heart disease Male Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stromal Cells - cytology Middle Aged Myocardial Ischemia - physiopathology Myocardial Ischemia - therapy Older people Quality of Life Statistical methods Stem cells Transplantation, Autologous Treatment Outcome Ventricular Remodeling - physiology |
| Title | Effect of Aging on Human Mesenchymal Stem Cell Therapy in Ischemic Cardiomyopathy Patients |
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