Cortical network dysfunction caused by a subtle defect of myelination

• Published in: Glia Vol. 64; no. 11; pp. 2025 - 2040
• Main Authors: Poggi, Giulia, Boretius, Susann, Möbius, Wiebke, Moschny, Nicole, Baudewig, Jürgen, Ruhwedel, Torben, Hassouna, Imam, Wieser, Georg L., Werner, Hauke B., Goebbels, Sandra, Nave, Klaus-Armin, Ehrenreich, Hannelore
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2016; Wiley Subscription Services, Inc; John Wiley and Sons Inc
• Subjects: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase - genetics; 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase - metabolism; Age Factors; Animals; catatonia; Cnp mutant; Disease Models, Animal; electron microscopy; Exploratory Behavior - physiology; Female; Leukoencephalopathies - diagnostic imaging; Leukoencephalopathies - genetics; Leukoencephalopathies - pathology; Leukoencephalopathies - physiopathology; Maze Learning - physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia - metabolism; Microglia - pathology; Microglia - ultrastructure; MRI; myelin basic protein (Mbp) mutant; Myelin Basic Protein - genetics; Myelin Basic Protein - metabolism; Myelin Sheath - genetics; Myelin Sheath - metabolism; Myelin Sheath - ultrastructure; Neural Pathways - metabolism; Neural Pathways - pathology; Neural Pathways - physiopathology; Nitric Oxide Synthase Type II - genetics; Nitric Oxide Synthase Type II - metabolism; NMR; Nuclear magnetic resonance; Pregnancy; prepulse inhibition; Prepulse Inhibition - genetics; Reflex, Startle - genetics; White Matter - pathology; White Matter - ultrastructure; catatonia; electron microscopy; prepulse inhibition; Cnp mutant; myelin basic protein (Mbp) mutant; MRI

Subtle white matter abnormalities have emerged as a hallmark of brain alterations in magnetic resonance imaging or upon autopsy of mentally ill subjects. However, it is unknown whether such reduction of white matter and myelin contributes to any disease‐relevant phenotype or simply constitutes an ep...