Native myocardial longitudinal (T1) relaxation time: Regional, age, and sex associations in the healthy adult heart

Purpose To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T1 relaxation time distribution, and global myocardial native T1 between sexes and across age groups. Materials and Methods In all, 84 healthy volunteers und...

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Published inJournal of magnetic resonance imaging Vol. 44; no. 3; pp. 541 - 548
Main Authors Rauhalammi, Samuli M.O., Mangion, Kenneth, Barrientos, Pauline Hall, Carrick, David J.A., Clerfond, Guillaume, McClure, John, McComb, Christie, Radjenovic, Aleksandra, Berry, Colin
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.09.2016
Wiley Subscription Services, Inc
John Wiley and Sons Inc
Subjects
Age
Aging - pathology
Aging - physiology
Cardiac Imaging Techniques - methods
Female
Gender differences
healthy volunteer
Heart Ventricles - anatomy & histology
Heart Ventricles - diagnostic imaging
Humans
longitudinal relaxation time
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
myocardium
native T1
NMR
Nuclear magnetic resonance
Original Research
Reference Values
Regression analysis
Reproducibility of Results
Sensitivity and Specificity
Sex Characteristics
T1 mapping
Ventricular Function, Left - physiology
native T1
longitudinal relaxation time
healthy volunteer
myocardium
T1 mapping
Online AccessGet full text

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Abstract Purpose To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T1 relaxation time distribution, and global myocardial native T1 between sexes and across age groups. Materials and Methods In all, 84 healthy volunteers underwent MRI at 1.5T and 3.0T. T1 maps were acquired in three left ventricular short axis slices using an optimized modified Look–Locker inversion recovery investigational prototype sequence. T1 measurements in msec were calculated from 16 regions‐of‐interest, and a global T1 value from all evaluable segments per subject. Associations were assessed with a multivariate linear regression model. Results In total, 1297 (96.5%) segments were evaluable at 1.5T and 1263 (94.0%) segments at 3.0T. Native T1 was higher in septal than lateral myocardium (1.5T: 956.3 ± 44.4 vs. 939.2 ± 54.2 msec; P < 0.001; 3.0T: 1158.2 ± 45.9 vs. 1148.9 ± 56.9 msec; P = 0.012). Native T1 decreased with increasing age in females but not in males. Among lowest age tertile (<33 years) global native T1 was higher in females than in males at 1.5T (960.0 ± 20.3 vs. 931.5 ± 22.2 msec, respectively; P = 0.003) and 3.0T (1166.5 ± 19.7 vs. 1130.2 ± 20.6 msec; P < 0.001). No sex differences were observed in upper age tertile (≥55 years) at 1.5T (937.7 ± 25.4 vs. 934.7 ± 22.3 msec; P = 0.762) or 3.0T (1153.0 ± 30.0 vs. 1132.3 ± 23.5 msec; P = 0.056). Association of global native T1 to age (P = 0.002) and sex (P < 0.001) was independent of field strength and body size. Conclusion In healthy adults, native T1 values are highest in the ventricular septum. Global native T1 was inversely associated with age in women, but not in men. J. Magn. Reson. Imaging 2016;44:541–548.
AbstractList To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T1 relaxation time distribution, and global myocardial native T1 between sexes and across age groups.PURPOSETo use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T1 relaxation time distribution, and global myocardial native T1 between sexes and across age groups.In all, 84 healthy volunteers underwent MRI at 1.5T and 3.0T. T1 maps were acquired in three left ventricular short axis slices using an optimized modified Look-Locker inversion recovery investigational prototype sequence. T1 measurements in msec were calculated from 16 regions-of-interest, and a global T1 value from all evaluable segments per subject. Associations were assessed with a multivariate linear regression model.MATERIALS AND METHODSIn all, 84 healthy volunteers underwent MRI at 1.5T and 3.0T. T1 maps were acquired in three left ventricular short axis slices using an optimized modified Look-Locker inversion recovery investigational prototype sequence. T1 measurements in msec were calculated from 16 regions-of-interest, and a global T1 value from all evaluable segments per subject. Associations were assessed with a multivariate linear regression model.In total, 1297 (96.5%) segments were evaluable at 1.5T and 1263 (94.0%) segments at 3.0T. Native T1 was higher in septal than lateral myocardium (1.5T: 956.3 ± 44.4 vs. 939.2 ± 54.2 msec; P < 0.001; 3.0T: 1158.2 ± 45.9 vs. 1148.9 ± 56.9 msec; P = 0.012). Native T1 decreased with increasing age in females but not in males. Among lowest age tertile (<33 years) global native T1 was higher in females than in males at 1.5T (960.0 ± 20.3 vs. 931.5 ± 22.2 msec, respectively; P = 0.003) and 3.0T (1166.5 ± 19.7 vs. 1130.2 ± 20.6 msec; P < 0.001). No sex differences were observed in upper age tertile (≥55 years) at 1.5T (937.7 ± 25.4 vs. 934.7 ± 22.3 msec; P = 0.762) or 3.0T (1153.0 ± 30.0 vs. 1132.3 ± 23.5 msec; P = 0.056). Association of global native T1 to age (P = 0.002) and sex (P < 0.001) was independent of field strength and body size.RESULTSIn total, 1297 (96.5%) segments were evaluable at 1.5T and 1263 (94.0%) segments at 3.0T. Native T1 was higher in septal than lateral myocardium (1.5T: 956.3 ± 44.4 vs. 939.2 ± 54.2 msec; P < 0.001; 3.0T: 1158.2 ± 45.9 vs. 1148.9 ± 56.9 msec; P = 0.012). Native T1 decreased with increasing age in females but not in males. Among lowest age tertile (<33 years) global native T1 was higher in females than in males at 1.5T (960.0 ± 20.3 vs. 931.5 ± 22.2 msec, respectively; P = 0.003) and 3.0T (1166.5 ± 19.7 vs. 1130.2 ± 20.6 msec; P < 0.001). No sex differences were observed in upper age tertile (≥55 years) at 1.5T (937.7 ± 25.4 vs. 934.7 ± 22.3 msec; P = 0.762) or 3.0T (1153.0 ± 30.0 vs. 1132.3 ± 23.5 msec; P = 0.056). Association of global native T1 to age (P = 0.002) and sex (P < 0.001) was independent of field strength and body size.In healthy adults, native T1 values are highest in the ventricular septum. Global native T1 was inversely associated with age in women, but not in men. J. Magn. Reson. Imaging 2016;44:541-548.CONCLUSIONIn healthy adults, native T1 values are highest in the ventricular septum. Global native T1 was inversely associated with age in women, but not in men. J. Magn. Reson. Imaging 2016;44:541-548.
Purpose To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T1 relaxation time distribution, and global myocardial native T1 between sexes and across age groups. Materials and Methods In all, 84 healthy volunteers underwent MRI at 1.5T and 3.0T. T1 maps were acquired in three left ventricular short axis slices using an optimized modified Look-Locker inversion recovery investigational prototype sequence. T1 measurements in msec were calculated from 16 regions-of-interest, and a global T1 value from all evaluable segments per subject. Associations were assessed with a multivariate linear regression model. Results In total, 1297 (96.5%) segments were evaluable at 1.5T and 1263 (94.0%) segments at 3.0T. Native T1 was higher in septal than lateral myocardium (1.5T: 956.3±44.4 vs. 939.2±54.2 msec; P < 0.001; 3.0T: 1158.2±45.9 vs. 1148.9±56.9 msec; P=0.012). Native T1 decreased with increasing age in females but not in males. Among lowest age tertile (<33 years) global native T1 was higher in females than in males at 1.5T (960.0±20.3 vs. 931.5±22.2 msec, respectively; P=0.003) and 3.0T (1166.5±19.7 vs. 1130.2±20.6 msec; P < 0.001). No sex differences were observed in upper age tertile (≥55 years) at 1.5T (937.7±25.4 vs. 934.7±22.3 msec; P=0.762) or 3.0T (1153.0±30.0 vs. 1132.3±23.5 msec; P=0.056). Association of global native T1 to age (P=0.002) and sex (P < 0.001) was independent of field strength and body size. Conclusion In healthy adults, native T1 values are highest in the ventricular septum. Global native T1 was inversely associated with age in women, but not in men. J. Magn. Reson. Imaging 2016;44:541-548.
To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T1 relaxation time distribution, and global myocardial native T1 between sexes and across age groups. In all, 84 healthy volunteers underwent MRI at 1.5T and 3.0T. T1 maps were acquired in three left ventricular short axis slices using an optimized modified Look-Locker inversion recovery investigational prototype sequence. T1 measurements in msec were calculated from 16 regions-of-interest, and a global T1 value from all evaluable segments per subject. Associations were assessed with a multivariate linear regression model. In total, 1297 (96.5%) segments were evaluable at 1.5T and 1263 (94.0%) segments at 3.0T. Native T1 was higher in septal than lateral myocardium (1.5T: 956.3 ± 44.4 vs. 939.2 ± 54.2 msec; P < 0.001; 3.0T: 1158.2 ± 45.9 vs. 1148.9 ± 56.9 msec; P = 0.012). Native T1 decreased with increasing age in females but not in males. Among lowest age tertile (<33 years) global native T1 was higher in females than in males at 1.5T (960.0 ± 20.3 vs. 931.5 ± 22.2 msec, respectively; P = 0.003) and 3.0T (1166.5 ± 19.7 vs. 1130.2 ± 20.6 msec; P < 0.001). No sex differences were observed in upper age tertile (≥55 years) at 1.5T (937.7 ± 25.4 vs. 934.7 ± 22.3 msec; P = 0.762) or 3.0T (1153.0 ± 30.0 vs. 1132.3 ± 23.5 msec; P = 0.056). Association of global native T1 to age (P = 0.002) and sex (P < 0.001) was independent of field strength and body size. In healthy adults, native T1 values are highest in the ventricular septum. Global native T1 was inversely associated with age in women, but not in men. J. Magn. Reson. Imaging 2016;44:541-548.
Purpose To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T sub(1) relaxation time distribution, and global myocardial native T sub(1) between sexes and across age groups. Materials and Methods In all, 84 healthy volunteers underwent MRI at 1.5T and 3.0T. T sub(1) maps were acquired in three left ventricular short axis slices using an optimized modified Look-Locker inversion recovery investigational prototype sequence. T sub(1) measurements in msec were calculated from 16 regions-of-interest, and a global T sub(1) value from all evaluable segments per subject. Associations were assessed with a multivariate linear regression model. Results In total, 1297 (96.5%) segments were evaluable at 1.5T and 1263 (94.0%) segments at 3.0T. Native T sub(1) was higher in septal than lateral myocardium (1.5T: 956.3 plus or minus 44.4 vs. 939.2 plus or minus 54.2 msec; P < 0.001; 3.0T: 1158.2 plus or minus 45.9 vs. 1148.9 plus or minus 56.9 msec; P=0.012). Native T sub(1) decreased with increasing age in females but not in males. Among lowest age tertile (<33 years) global native T sub(1) was higher in females than in males at 1.5T (960.0 plus or minus 20.3 vs. 931.5 plus or minus 22.2 msec, respectively; P=0.003) and 3.0T (1166.5 plus or minus 19.7 vs. 1130.2 plus or minus 20.6 msec; P < 0.001). No sex differences were observed in upper age tertile ( greater than or equal to 55 years) at 1.5T (937.7 plus or minus 25.4 vs. 934.7 plus or minus 22.3 msec; P=0.762) or 3.0T (1153.0 plus or minus 30.0 vs. 1132.3 plus or minus 23.5 msec; P=0.056). Association of global native T sub(1) to age (P=0.002) and sex (P < 0.001) was independent of field strength and body size. Conclusion In healthy adults, native T sub(1) values are highest in the ventricular septum. Global native T sub(1) was inversely associated with age in women, but not in men. J. Magn. Reson. Imaging 2016; 44:541-548.
Purpose To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T1 relaxation time distribution, and global myocardial native T1 between sexes and across age groups. Materials and Methods In all, 84 healthy volunteers underwent MRI at 1.5T and 3.0T. T1 maps were acquired in three left ventricular short axis slices using an optimized modified Look–Locker inversion recovery investigational prototype sequence. T1 measurements in msec were calculated from 16 regions‐of‐interest, and a global T1 value from all evaluable segments per subject. Associations were assessed with a multivariate linear regression model. Results In total, 1297 (96.5%) segments were evaluable at 1.5T and 1263 (94.0%) segments at 3.0T. Native T1 was higher in septal than lateral myocardium (1.5T: 956.3 ± 44.4 vs. 939.2 ± 54.2 msec; P < 0.001; 3.0T: 1158.2 ± 45.9 vs. 1148.9 ± 56.9 msec; P = 0.012). Native T1 decreased with increasing age in females but not in males. Among lowest age tertile (<33 years) global native T1 was higher in females than in males at 1.5T (960.0 ± 20.3 vs. 931.5 ± 22.2 msec, respectively; P = 0.003) and 3.0T (1166.5 ± 19.7 vs. 1130.2 ± 20.6 msec; P < 0.001). No sex differences were observed in upper age tertile (≥55 years) at 1.5T (937.7 ± 25.4 vs. 934.7 ± 22.3 msec; P = 0.762) or 3.0T (1153.0 ± 30.0 vs. 1132.3 ± 23.5 msec; P = 0.056). Association of global native T1 to age (P = 0.002) and sex (P < 0.001) was independent of field strength and body size. Conclusion In healthy adults, native T1 values are highest in the ventricular septum. Global native T1 was inversely associated with age in women, but not in men. J. Magn. Reson. Imaging 2016;44:541–548.
Author Clerfond, Guillaume
Mangion, Kenneth
Carrick, David J.A.
Rauhalammi, Samuli M.O.
Barrientos, Pauline Hall
McClure, John
McComb, Christie
Radjenovic, Aleksandra
Berry, Colin
AuthorAffiliation 2 West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital Glasgow UK
1 BHF Glasgow Cardiovascular Research Centre University of Glasgow Glasgow UK
3 Department of Clinical Physics Queen Elizabeth University Hospital Glasgow Glasgow UK
AuthorAffiliation_xml – name: 1 BHF Glasgow Cardiovascular Research Centre University of Glasgow Glasgow UK
– name: 3 Department of Clinical Physics Queen Elizabeth University Hospital Glasgow Glasgow UK
– name: 2 West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital Glasgow UK
Author_xml – sequence: 1
  givenname: Samuli M.O.
  surname: Rauhalammi
  fullname: Rauhalammi, Samuli M.O.
  organization: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
– sequence: 2
  givenname: Kenneth
  surname: Mangion
  fullname: Mangion, Kenneth
  organization: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
– sequence: 3
  givenname: Pauline Hall
  surname: Barrientos
  fullname: Barrientos, Pauline Hall
  organization: Department of Clinical Physics, Queen Elizabeth University Hospital, Glasgow, Glasgow, UK
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  organization: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
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  fullname: McComb, Christie
  organization: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
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  surname: Radjenovic
  fullname: Radjenovic, Aleksandra
  organization: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
– sequence: 9
  givenname: Colin
  surname: Berry
  fullname: Berry, Colin
  email: colin.berry@glasgow.ac.uk
  organization: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26946323$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2016 The Authors Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine
2016 The Authors Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.
2016 Wiley Periodicals, Inc.
Copyright_xml – notice: 2016 The Authors Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine
– notice: 2016 The Authors Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.
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Issue 3
Keywords native T1
longitudinal relaxation time
healthy volunteer
myocardium
T1 mapping
Language English
License Attribution
http://creativecommons.org/licenses/by/4.0
2016 The Authors Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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PublicationTitle Journal of magnetic resonance imaging
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References Scholz T, Martins J, Skorton D. NMR relaxation times in acute myocardial infarction: relative influence of changes in tissue water and fat content. Magn Reson Med 1992;23:89-95.
Sado D, White S, Piechnik S, et al. Identification and assessment of Anderson-Fabry disease by cardiovascular magnetic resonance noncontrast myocardial T1 mapping. Circ Cardiovasc Imaging 2013;6:392-398.
Flett A, Sado D, Quarta G, et al. Diffuse myocardial fibrosis in severe aortic stenosis: an equilibrium contrast cardiovascular magnetic resonance study. Eur Heart J Cardiovasc Imaging 2012;13:819-826.
Sado D, Flett A, Banypersad S, et al. Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease. Heart 2012;98:1436-1441.
van Eickels M, Grohe C, Cleutjens J, Janssen B, Wellens H, Doevendans P. 17 beta-estradiol attenuates the development of pressure-overload hypertrophy. Circulation 2001;104:1419-1423.
Kellman P, Hansen M. T1-mapping in the heart: accuracy and precision. J Cardiovasc Magn Reson 2014;16:2.
Kawel N, Nacif M, Zavodni A, et al. T1 mapping of the myocardium: intra-individual assessment of post-contrast T1 time evolution and extracellular volume fraction at 3T for Gd-DTPA and Gd-BOPTA. J Cardiovasc Magn Reson 2012;14:26.
Kannel W, Wilson P. Risk-factors that attenuate the female coronary disease advantage. Arch Intern Med 1995;155:57-61.
Piechnik S, Ferreira V, Lewandowski A, et al. Normal variation of magnetic resonance T1 relaxation times in the human population at 1.5 T using ShMOLLI. J Cardiovasc Magn Reson 2013;15:13.
McDiarmid AK, Broadbent DA, Higgins DM, et al. The effect of changes to MOLLI scheme on T1 mapping and extra cellular volume calculation in healthy volunteers with 3 Tesla cardiovascular magnetic resonance imaging. Quant Imaging Med Surg 2015;5:503-510.
Moon J, Messroghli D, Kellman P, et al. Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magn Reson 2013;15:92.
Messroghli D, Greiser A, Frohlich M, Dietz R, Schulz-Menger J. Optimization and validation of a fully-integrated pulse sequence for modified Look-Locker inversion-recovery (MOLLI) T1 mapping of the heart. J Magn Reson Imaging 2007;26:1081-1086.
Chuang M, Gona P, Hautvast G, et al. CMR reference values for left ventricular volumes, mass, and ejection fraction using computer-aided analysis: the Framingham Heart Study. J Magn Reson Imaging 2014;39:895-900.
Oshinski J, Delfino J, Sharma P, Gharib A, Pettigrew R. Cardiovascular magnetic resonance at 3.0T: current state of the art. J Cardiovasc Magn Reson 2010;12:55.
Kellman P, Arai A, McVeigh E, Aletras A. Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement. Magn Reson Med 2002;47:372-383.
Farahani K, Sinha U, Sinha S, Chiu LC, Lufkin RB. Effect of field strength on susceptibility artifacts in magnetic resonance imaging. Comput Med Imaging Graph 1990;14:409-413.
de Ravenstein C, Bouzin C, Lazam S, et al. Histological Validation of measurement of diffuse interstitial myocardial fibrosis by myocardial extravascular volume fraction from modified Look-Locker imaging (MOLLI) T1 mapping at 3 T. J Cardiovasc Magn Reson 2015;17.
Dabir D, Child N, Kalra A, et al. Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 2014;16:69.
Ferreira V, Piechnik S, Dall'Armellina E, et al. Non-contrast T1-mapping detects acute myocardial edema with high diagnostic accuracy: a comparison to T2-weighted cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2012;14:42.
Messroghli D, Radjenovic A, Kozerke S, Higgins D, Sivananthan M, Ridgway J. Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med 2004;52:141-146.
Karamitsos T, Piechnik S, Banypersad S, et al. Noncontrast T1 mapping for the diagnosis of cardiac amyloidosis. JACC Cardiovasc Imaging 2013;6:488-497.
Xue H, Guehring J, Srinivasan L, et al. Evaluation of rigid and non-rigid motion compensation of cardiac perfusion MRI. Med Image Comput Comput Assist Intervent 2008, Pt Ii, Proc 2008;5242:35-43.
Mendelsohn M, Karas R. Molecular and cellular basis of cardiovascular gender differences. Science 2005;308:1583-1587.
Wieben O, Francois C, Reeder S. Cardiac MRI of ischemic heart disease at 3 T: potential and challenges. Eur J Radiol 2008;65:15-28.
Cerqueira M, Weissman N, Dilsizian V, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 2002;105:539-542.
Rosano G, Vitale C, Marazzi G, Volterrani M. Menopause and cardiovascular disease: the evidence. Climacteric 2007;10:19-24.
Treibel T, Fontana M, Maestrini V, et al. Synthetic ECV: simplifying ECV quantification by deriving haematocrit from T1 blood. Heart 2015;101:A16-A17.
Piechnik S, Ferreira V, Lewandowski A, et al. Age and gender dependence of pre-contrast T1-relaxation times in normal human myocardium at 1.5T using ShMOLLI. J Cardiovasc Magn Reson 2012;14:P221.
Florian A, Ludwig A, Rosch S, Yildiz H, Sechtem U, Yilmaz A. Myocardial fibrosis imaging based on T1-mapping and extracellular volume fraction (ECV) measurement in muscular dystrophy patients: diagnostic value compared with conventional late gadolinium enhancement (LGE) imaging. Eur Heart J Cardiovasc Imaging 2014;15:1004-1012.
Ferreira P, Gatehouse P, Mohiaddin R, Firmin D. Cardiovascular magnetic resonance artefacts. J Cardiovasc Magn Reson 2013;15:14.
Regitz-Zagrosek V. Therapeutic implications of the gender-specific aspects of cardiovascular disease. Nat Rev Drug Discov 2006;5:425-438.
Kellman P, Wilson J, Xue H, Ugander M, Arai A. Extracellular volume fraction mapping in the myocardium, part 1: evaluation of an automated method. J Cardiovasc Magn Reson 2012;14.
Gold GE, Han E, Stainsby J, et al. Musculoskeletal MRI at 3.0 T: relaxation times and image contrast. Am J Roentgenol 2004;183;343-351.
Nacif M, Turkbey E, Gai N, et al. Myocardial T1 mapping with MRI: comparison of Look-Locker and MOLLI sequences. J Magn Reson Imaging 2011;34:1367-1373.
Kramer C, Barkhausen J, Flamm S, Kim R, Nagel E. Standardized cardiovascular magnetic resonance imaging (CMR) protocols, society for cardiovascular magnetic resonance: board of trustees task force on standardized protocols. J Cardiovasc Magn Reson 2008;10:35.
Du Bois D, Du Bois E. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 1916;17:863-871.
Rogers T, Dabir D, Mahmoud I, et al. Standardization of T1 measurements with MOLLI in differentiation between health and disease: the ConSept study. J Cardiovasc Magn Reson 2013;15:78.
Ferreira V, Piechnik S, Dall'Armellina E, et al. Native T1-mapping detects the location, extent and patterns of acute myocarditis without the need for gadolinium contrast agents. J Cardiovasc Magn Reson 2014;16:36.
Liu C, Liu Y, Wu C, et al. Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 2013;62:1280-1287.
von Knobelsdorff-Brenkenhoff F, Prothmann M, Dieringer M, et al. Myocardial T1 and T2 mapping at 3 T: reference values, influencing factors and implications. J Cardiovasc Magn Reson 2013;15:53.
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References_xml – reference: Kellman P, Hansen M. T1-mapping in the heart: accuracy and precision. J Cardiovasc Magn Reson 2014;16:2.
– reference: Ferreira V, Piechnik S, Dall'Armellina E, et al. Native T1-mapping detects the location, extent and patterns of acute myocarditis without the need for gadolinium contrast agents. J Cardiovasc Magn Reson 2014;16:36.
– reference: Kellman P, Wilson J, Xue H, Ugander M, Arai A. Extracellular volume fraction mapping in the myocardium, part 1: evaluation of an automated method. J Cardiovasc Magn Reson 2012;14.
– reference: Rosano G, Vitale C, Marazzi G, Volterrani M. Menopause and cardiovascular disease: the evidence. Climacteric 2007;10:19-24.
– reference: Liu C, Liu Y, Wu C, et al. Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 2013;62:1280-1287.
– reference: de Ravenstein C, Bouzin C, Lazam S, et al. Histological Validation of measurement of diffuse interstitial myocardial fibrosis by myocardial extravascular volume fraction from modified Look-Locker imaging (MOLLI) T1 mapping at 3 T. J Cardiovasc Magn Reson 2015;17.
– reference: Florian A, Ludwig A, Rosch S, Yildiz H, Sechtem U, Yilmaz A. Myocardial fibrosis imaging based on T1-mapping and extracellular volume fraction (ECV) measurement in muscular dystrophy patients: diagnostic value compared with conventional late gadolinium enhancement (LGE) imaging. Eur Heart J Cardiovasc Imaging 2014;15:1004-1012.
– reference: Nacif M, Turkbey E, Gai N, et al. Myocardial T1 mapping with MRI: comparison of Look-Locker and MOLLI sequences. J Magn Reson Imaging 2011;34:1367-1373.
– reference: Dabir D, Child N, Kalra A, et al. Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 2014;16:69.
– reference: van Eickels M, Grohe C, Cleutjens J, Janssen B, Wellens H, Doevendans P. 17 beta-estradiol attenuates the development of pressure-overload hypertrophy. Circulation 2001;104:1419-1423.
– reference: von Knobelsdorff-Brenkenhoff F, Prothmann M, Dieringer M, et al. Myocardial T1 and T2 mapping at 3 T: reference values, influencing factors and implications. J Cardiovasc Magn Reson 2013;15:53.
– reference: Sado D, White S, Piechnik S, et al. Identification and assessment of Anderson-Fabry disease by cardiovascular magnetic resonance noncontrast myocardial T1 mapping. Circ Cardiovasc Imaging 2013;6:392-398.
– reference: Flett A, Sado D, Quarta G, et al. Diffuse myocardial fibrosis in severe aortic stenosis: an equilibrium contrast cardiovascular magnetic resonance study. Eur Heart J Cardiovasc Imaging 2012;13:819-826.
– reference: Cerqueira M, Weissman N, Dilsizian V, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 2002;105:539-542.
– reference: Xue H, Guehring J, Srinivasan L, et al. Evaluation of rigid and non-rigid motion compensation of cardiac perfusion MRI. Med Image Comput Comput Assist Intervent 2008, Pt Ii, Proc 2008;5242:35-43.
– reference: Messroghli D, Greiser A, Frohlich M, Dietz R, Schulz-Menger J. Optimization and validation of a fully-integrated pulse sequence for modified Look-Locker inversion-recovery (MOLLI) T1 mapping of the heart. J Magn Reson Imaging 2007;26:1081-1086.
– reference: Treibel T, Fontana M, Maestrini V, et al. Synthetic ECV: simplifying ECV quantification by deriving haematocrit from T1 blood. Heart 2015;101:A16-A17.
– reference: Moon J, Messroghli D, Kellman P, et al. Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magn Reson 2013;15:92.
– reference: Du Bois D, Du Bois E. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 1916;17:863-871.
– reference: Sado D, Flett A, Banypersad S, et al. Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease. Heart 2012;98:1436-1441.
– reference: Piechnik S, Ferreira V, Lewandowski A, et al. Normal variation of magnetic resonance T1 relaxation times in the human population at 1.5 T using ShMOLLI. J Cardiovasc Magn Reson 2013;15:13.
– reference: Kannel W, Wilson P. Risk-factors that attenuate the female coronary disease advantage. Arch Intern Med 1995;155:57-61.
– reference: Farahani K, Sinha U, Sinha S, Chiu LC, Lufkin RB. Effect of field strength on susceptibility artifacts in magnetic resonance imaging. Comput Med Imaging Graph 1990;14:409-413.
– reference: Oshinski J, Delfino J, Sharma P, Gharib A, Pettigrew R. Cardiovascular magnetic resonance at 3.0T: current state of the art. J Cardiovasc Magn Reson 2010;12:55.
– reference: Mendelsohn M, Karas R. Molecular and cellular basis of cardiovascular gender differences. Science 2005;308:1583-1587.
– reference: Karamitsos T, Piechnik S, Banypersad S, et al. Noncontrast T1 mapping for the diagnosis of cardiac amyloidosis. JACC Cardiovasc Imaging 2013;6:488-497.
– reference: Rogers T, Dabir D, Mahmoud I, et al. Standardization of T1 measurements with MOLLI in differentiation between health and disease: the ConSept study. J Cardiovasc Magn Reson 2013;15:78.
– reference: Ferreira V, Piechnik S, Dall'Armellina E, et al. Non-contrast T1-mapping detects acute myocardial edema with high diagnostic accuracy: a comparison to T2-weighted cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2012;14:42.
– reference: Kramer C, Barkhausen J, Flamm S, Kim R, Nagel E. Standardized cardiovascular magnetic resonance imaging (CMR) protocols, society for cardiovascular magnetic resonance: board of trustees task force on standardized protocols. J Cardiovasc Magn Reson 2008;10:35.
– reference: Chuang M, Gona P, Hautvast G, et al. CMR reference values for left ventricular volumes, mass, and ejection fraction using computer-aided analysis: the Framingham Heart Study. J Magn Reson Imaging 2014;39:895-900.
– reference: Messroghli D, Radjenovic A, Kozerke S, Higgins D, Sivananthan M, Ridgway J. Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med 2004;52:141-146.
– reference: Gold GE, Han E, Stainsby J, et al. Musculoskeletal MRI at 3.0 T: relaxation times and image contrast. Am J Roentgenol 2004;183;343-351.
– reference: Kawel N, Nacif M, Zavodni A, et al. T1 mapping of the myocardium: intra-individual assessment of post-contrast T1 time evolution and extracellular volume fraction at 3T for Gd-DTPA and Gd-BOPTA. J Cardiovasc Magn Reson 2012;14:26.
– reference: Piechnik S, Ferreira V, Lewandowski A, et al. Age and gender dependence of pre-contrast T1-relaxation times in normal human myocardium at 1.5T using ShMOLLI. J Cardiovasc Magn Reson 2012;14:P221.
– reference: McDiarmid AK, Broadbent DA, Higgins DM, et al. The effect of changes to MOLLI scheme on T1 mapping and extra cellular volume calculation in healthy volunteers with 3 Tesla cardiovascular magnetic resonance imaging. Quant Imaging Med Surg 2015;5:503-510.
– reference: Scholz T, Martins J, Skorton D. NMR relaxation times in acute myocardial infarction: relative influence of changes in tissue water and fat content. Magn Reson Med 1992;23:89-95.
– reference: Kellman P, Arai A, McVeigh E, Aletras A. Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement. Magn Reson Med 2002;47:372-383.
– reference: Regitz-Zagrosek V. Therapeutic implications of the gender-specific aspects of cardiovascular disease. Nat Rev Drug Discov 2006;5:425-438.
– reference: Ferreira P, Gatehouse P, Mohiaddin R, Firmin D. Cardiovascular magnetic resonance artefacts. J Cardiovasc Magn Reson 2013;15:14.
– reference: Wieben O, Francois C, Reeder S. Cardiac MRI of ischemic heart disease at 3 T: potential and challenges. Eur J Radiol 2008;65:15-28.
– volume: 47
  start-page: 372
  year: 2002
  end-page: 383
  article-title: Phase‐sensitive inversion recovery for detecting myocardial infarction using gadolinium‐delayed hyperenhancement
  publication-title: Magn Reson Med
– volume: 6
  start-page: 488
  year: 2013
  end-page: 497
  article-title: Noncontrast T1 mapping for the diagnosis of cardiac amyloidosis
  publication-title: JACC Cardiovasc Imaging
– volume: 23
  start-page: 89
  year: 1992
  end-page: 95
  article-title: NMR relaxation times in acute myocardial infarction: relative influence of changes in tissue water and fat content
  publication-title: Magn Reson Med
– volume: 26
  start-page: 1081
  year: 2007
  end-page: 1086
  article-title: Optimization and validation of a fully‐integrated pulse sequence for modified Look–Locker inversion‐recovery (MOLLI) T1 mapping of the heart
  publication-title: J Magn Reson Imaging
– volume: 15
  start-page: 78
  year: 2013
  article-title: Standardization of T1 measurements with MOLLI in differentiation between health and disease: the ConSept study
  publication-title: J Cardiovasc Magn Reson
– volume: 14
  start-page: 409
  year: 1990
  end-page: 413
  article-title: Effect of field strength on susceptibility artifacts in magnetic resonance imaging
  publication-title: Comput Med Imaging Graph
– volume: 65
  start-page: 15
  year: 2008
  end-page: 28
  article-title: Cardiac MRI of ischemic heart disease at 3 T: potential and challenges
  publication-title: Eur J Radiol
– volume: 16
  start-page: 36
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Snippet Purpose To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T1 relaxation time...
To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T1 relaxation time...
Purpose To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T1 relaxation time...
Purpose To use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T sub(1) relaxation...
SourceID pubmedcentral
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crossref
wiley
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SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 541
SubjectTerms Age
Aging - pathology
Aging - physiology
Cardiac Imaging Techniques - methods
Female
Gender differences
healthy volunteer
Heart Ventricles - anatomy & histology
Heart Ventricles - diagnostic imaging
Humans
longitudinal relaxation time
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
myocardium
native T1
NMR
Nuclear magnetic resonance
Original Research
Reference Values
Regression analysis
Reproducibility of Results
Sensitivity and Specificity
Sex Characteristics
T1 mapping
Ventricular Function, Left - physiology
Title Native myocardial longitudinal (T1) relaxation time: Regional, age, and sex associations in the healthy adult heart
URI https://api.istex.fr/ark:/67375/WNG-2WCM5BSB-X/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjmri.25217
https://www.ncbi.nlm.nih.gov/pubmed/26946323
https://www.proquest.com/docview/1811042574
https://www.proquest.com/docview/1811299330
https://www.proquest.com/docview/1815691938
https://pubmed.ncbi.nlm.nih.gov/PMC5025725
Volume 44
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