Monitoring of chronic wasting disease using real-time quaking-induced conversion assay in Japan

There has been no report on Chronic wasting disease (CWD) cases in Japan to date; however, there is concern about the geographic spread of CWD. To clarify the CWD status in Japan, we conducted CWD monitoring using real-time quaking-induced conversion (RT-QuIC) assay which can detect the low level of...

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Published inJournal of Veterinary Medical Science Vol. 83; no. 11; pp. 1735 - 1739
Main Authors SAWADA, Kazuhei, YAMASAKI, Takeshi, SUGA, Kinuyo, ERDENEBAT, Temuulen, HORIUCHI, Motohiro, SUZUKI, Akio, TOBIUME, Minoru
Format Journal Article
LanguageEnglish
Published JAPANESE SOCIETY OF VETERINARY SCIENCE 2021
The Japanese Society of Veterinary Science
Subjects
chronic wasting disease
prion
prion protein
Public Health
real-time quaking-induced conversion
scrapie
Online AccessGet full text
ISSN0916-7250
1347-7439
1347-7439
DOI10.1292/jvms.21-0368

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Abstract There has been no report on Chronic wasting disease (CWD) cases in Japan to date; however, there is concern about the geographic spread of CWD. To clarify the CWD status in Japan, we conducted CWD monitoring using real-time quaking-induced conversion (RT-QuIC) assay which can detect the low level of CWD prions. A total of 690 obex samples collected from sika deer and Reeves’s muntjac in Hokkaido and Honshu was tested for CWD prions. No CWD-positive cases were found, suggesting that CWD is nonexistent in Japan. Our results also indicate that RT-QuIC assay is useful for continuous monitoring of CWD. Furthermore, nucleotide sequence analysis of the PrP gene revealed sika deer in Japan harbor CWD susceptible allele.
AbstractList There has been no report on Chronic wasting disease (CWD) cases in Japan to date; however, there is concern about the geographic spread of CWD. To clarify the CWD status in Japan, we conducted CWD monitoring using real-time quaking-induced conversion (RT-QuIC) assay which can detect the low level of CWD prions. A total of 690 obex samples collected from sika deer and Reeves’s muntjac in Hokkaido and Honshu was tested for CWD prions. No CWD-positive cases were found, suggesting that CWD is nonexistent in Japan. Our results also indicate that RT-QuIC assay is useful for continuous monitoring of CWD. Furthermore, nucleotide sequence analysis of the PrP gene revealed sika deer in Japan harbor CWD susceptible allele.
There has been no report on Chronic wasting disease (CWD) cases in Japan to date; however, there is concern about the geographic spread of CWD. To clarify the CWD status in Japan, we conducted CWD monitoring using real-time quaking-induced conversion (RT-QuIC) assay which can detect the low level of CWD prions. A total of 690 obex samples collected from sika deer and Reeves's muntjac in Hokkaido and Honshu was tested for CWD prions. No CWD-positive cases were found, suggesting that CWD is nonexistent in Japan. Our results also indicate that RT-QuIC assay is useful for continuous monitoring of CWD. Furthermore, nucleotide sequence analysis of the PrP gene revealed sika deer in Japan harbor CWD susceptible allele.There has been no report on Chronic wasting disease (CWD) cases in Japan to date; however, there is concern about the geographic spread of CWD. To clarify the CWD status in Japan, we conducted CWD monitoring using real-time quaking-induced conversion (RT-QuIC) assay which can detect the low level of CWD prions. A total of 690 obex samples collected from sika deer and Reeves's muntjac in Hokkaido and Honshu was tested for CWD prions. No CWD-positive cases were found, suggesting that CWD is nonexistent in Japan. Our results also indicate that RT-QuIC assay is useful for continuous monitoring of CWD. Furthermore, nucleotide sequence analysis of the PrP gene revealed sika deer in Japan harbor CWD susceptible allele.
There has been no report on Chronic wasting disease (CWD) cases in Japan to date; however, there is concern about the geographic spread of CWD. To clarify the CWD status in Japan, we conducted CWD monitoring using real-time quaking-induced conversion (RT-QuIC) assay which can detect the low level of CWD prions. A total of 690 obex samples collected from sika deer and Reeves’s muntjac in Hokkaido and Honshu was tested for CWD prions. No CWD-positive cases were found, suggesting that CWD is nonexistent in Japan. Our results also indicate that RT-QuIC assay is useful for continuous monitoring of CWD. Furthermore, nucleotide sequence analysis of the PrP gene revealed sika deer in Japan harbor CWD susceptible allele.
ArticleNumber 21-0368
Author SUGA, Kinuyo
SUZUKI, Akio
HORIUCHI, Motohiro
SAWADA, Kazuhei
TOBIUME, Minoru
YAMASAKI, Takeshi
ERDENEBAT, Temuulen
Author_xml – sequence: 1
  fullname: SAWADA, Kazuhei
  organization: Laboratory of Veterinary Hygiene, Faculty of Veterinary Medicine, Graduate School of Infectious Diseases, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
– sequence: 1
  fullname: YAMASAKI, Takeshi
  organization: Biomedical Animal Research Laboratory, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0815, Japan
– sequence: 1
  fullname: SUGA, Kinuyo
  organization: Hyogo Prefecture Nishiharima Meat Hygiene Inspection Office, Shingu-cho, Tatsuno, Hyogo 679-4322, Japan
– sequence: 1
  fullname: ERDENEBAT, Temuulen
  organization: Laboratory of Veterinary Hygiene, Faculty of Veterinary Medicine, Graduate School of Infectious Diseases, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
– sequence: 1
  fullname: HORIUCHI, Motohiro
  organization: Global Station for Zoonosis Control, Global Institute for Collaborative Research and Education, Hokkaido University, Kita 20, Nishi 10, Kita-ku, Sapporo, Hokkaido 001-0020, Japan
– sequence: 1
  fullname: SUZUKI, Akio
  organization: Laboratory of Veterinary Hygiene, Faculty of Veterinary Medicine, Graduate School of Infectious Diseases, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
– sequence: 1
  fullname: TOBIUME, Minoru
  organization: Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan
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References_xml – reference: 18. Race, B., Meade-White, K. D., Miller, M. W., Barbian, K. D., Rubenstein, R., LaFauci, G., Cervenakova, L., Favara, C., Gardner, D., Long, D., Parnell, M., Striebel, J., Priola, S. A., Ward, A., Williams, E. S., Race, R. and Chesebro, B. 2009. Susceptibilities of nonhuman primates to chronic wasting disease. Emerg. Infect. Dis. 15: 1366–1376.
– reference: 19. Saborio, G. P., Permanne, B. and Soto, C. 2001. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 411: 810–813.
– reference: 10. Kataoka, N., Nishimura, M., Horiuchi, M. and Ishiguro, N. 2005. Surveillance of chronic wasting disease in sika deer, Cervus nippon, from Tokachi district in Hokkaido. J. Vet. Med. Sci. 67: 349–351.
– reference: 14. Mathiason, C. K., Powers, J. G., Dahmes, S. J., Osborn, D. A., Miller, K. V., Warren, R. J., Mason, G. L., Hays, S. A., Hayes-Klug, J., Seelig, D. M., Wild, M. A., Wolfe, L. L., Spraker, T. R., Miller, M. W., Sigurdson, C. J., Telling, G. C. and Hoover, E. A. 2006. Infectious prions in the saliva and blood of deer with chronic wasting disease. Science 314: 133–136.
– reference: 16. Ministry of Agriculture Forestry and Fisheries (MAFF). 2020. Statistical Data, Survey on Wildlife Resource Utilization. https://www.maff.go.jp/j/tokei/kouhyou/jibie/index.html [accessed on June 14, 2021].
– reference: 1. Agriculture & Livestock Industries Corporation (ALIC). 2021. Statistical Data, Livestock and Livestock Products. https://www.alic.go.jp/joho-c/joho05_000073.html [accessed on May 31, 2021].
– reference: 12. Koutsoumanis, K., Allende, A., Alvarez-Ordoňez, A., Bolton, D., Bover-Cid, S., Chemaly, M., Davies, R., De Cesare, A., Herman, L., Hilbert, F., Lindqvist, R., Nauta, M., Peixe, L., Ru, G., Skandamis, P., Suffredini, E., Andreoletti, O., Benestad, S. L., Comoy, E., Nonno, R., da Silva Felicio, T., Ortiz-Pelaez, A., Simmons, M. M., EFSA Panel on Biological Hazards (BIOHAZ). 2019. Update on chronic wasting disease (CWD) III. EFSA J. 17: e05863.
– reference: 9. Jewell, J. E., Conner, M. M., Wolfe, L. L., Miller, M. W. and Williams, E. S. 2005. Low frequency of PrP genotype 225SF among free-ranging mule deer (Odocoileus hemionus) with chronic wasting disease. J. Gen. Virol. 86: 2127–2134.
– reference: 7. Henderson, D. M., Davenport, K. A., Haley, N. J., Denkers, N. D., Mathiason, C. K. and Hoover, E. A. 2015. Quantitative assessment of prion infectivity in tissues and body fluids by real-time quaking-induced conversion. J. Gen. Virol. 96: 210–219.
– reference: 20. Suzuki, A., Sawada, K., Yamasaki, T., Denkers, N. D., Mathiason, C. K., Hoover, E. A. and Horiuchi, M. 2020. Involvement of N- and C-terminal region of recombinant cervid prion protein in its reactivity to CWD and atypical BSE prions in real-time quaking-induced conversion reaction in the presence of high concentrations of tissue homogenates. Prion 14: 283–295.
– reference: 6. Haley, N. J., Carver, S., Hoon-Hanks, L. L., Henderson, D. M., Davenport, K. A., Bunting, E., Gray, S., Trindle, B., Galeota, J., LeVan, I., Dubovos, T., Shelton, P. and Hoover, E. A. 2014. Detection of chronic wasting disease in the lymph nodes of free-ranging cervids by real-time quaking-induced conversion. J. Clin. Microbiol. 52: 3237–3243.
– reference: 17. Pritzkow, S., Morales, R., Moda, F., Khan, U., Telling, G. C., Hoover, E. and Soto, C. 2015. Grass plants bind, retain, uptake, and transport infectious prions. Cell Rep. 11: 1168–1175.
– reference: 13. Masujin, K., Shimada, K., Kimura, K. M., Imamura, M., Yoshida, A., Iwamaru, Y., Mohri, S. and Yokoyama, T. 2007. Applicability of current bovine spongiform encephalopathy (BSE) diagnostic procedures for chronic wasting disease (CWD). Microbiol. Immunol. 51: 1039–1043.
– reference: 15. Meng, L. P., Zhao, D. M., Liu, H. X., Yang, J. M., Ning, Z. Y., Wu, C. D. and Han, C. X. 2005. Polymorphisms of the prion protein gene (PRNP) in Chinese domestic sika deer (Cervus nippon hortulorum). Anim. Genet. 36: 266–267.
– reference: 5. Haley, N. J. and Hoover, E. A. 2015. Chronic wasting disease of cervids: current knowledge and future perspectives. Annu. Rev. Anim. Biosci. 3: 305–325.
– reference: 11. Kong, Q., Huang, S., Zou, W., Vanegas, D., Wang, M., Wu, D., Yuan, J., Zheng, M., Bai, H., Deng, H., Chen, K., Jenny, A. L., O’Rourke, K., Belay, E. D., Schonberger, L. B., Petersen, R. B., Sy, M. S., Chen, S. G. and Gambetti, P. 2005. Chronic wasting disease of elk: transmissibility to humans examined by transgenic mouse models. J. Neurosci. 25: 7944–7949.
– reference: 8. Houston, F. and Andréoletti, O. 2019. Animal prion diseases: the risks to human health. Brain Pathol. 29: 248–262.
– reference: 3. Atarashi, R., Satoh, K., Sano, K., Fuse, T., Yamaguchi, N., Ishibashi, D., Matsubara, T., Nakagaki, T., Yamanaka, H., Shirabe, S., Yamada, M., Mizusawa, H., Kitamoto, T., Klug, G., McGlade, A., Collins, S. J. and Nishida, N. 2011. Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nat. Med. 17: 175–178.
– reference: 2. Arifin, M. I., Hannaoui, S., Chang, S. C., Thapa, S., Schatzl, H. M. and Gilch, S. 2021. Cervid prion protein polymorphisms: role in chronic wasting disease pathogenesis. Int. J. Mol. Sci. 22: 2271.
– reference: 4. Escobar, L. E., Pritzkow, S., Winter, S. N., Grear, D. A., Kirchgessner, M. S., Dominguez-Villegas, E., Machado, G., Townsend Peterson, A. and Soto, C. 2020. The ecology of chronic wasting disease in wildlife. Biol. Rev. Camb. Philos. Soc. 95: 393–408.
– reference: 21. Vikøren, T., Våge, J., Madslien, K. I., Røed, K. H., Rolandsen, C. M., Tran, L., Hopp, P., Veiberg, V., Heum, M., Moldal, T., Neves, C. G. D., Handeland, K., Ytrehus, B., Kolbjørnsen, Ø., Wisløff, H., Terland, R., Saure, B., Dessen, K. M., Svendsen, S. G., Nordvik, B. S. and Benestad, S. L. 2019. First detection of chronic wasting disease in a wild red deer (Cervus elaphus) in Europe. J. Wildl. Dis. 55: 970–972.
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Snippet There has been no report on Chronic wasting disease (CWD) cases in Japan to date; however, there is concern about the geographic spread of CWD. To clarify the...
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SubjectTerms chronic wasting disease
prion
prion protein
Public Health
real-time quaking-induced conversion
scrapie
Title Monitoring of chronic wasting disease using real-time quaking-induced conversion assay in Japan
URI https://www.jstage.jst.go.jp/article/jvms/83/11/83_21-0368/_article/-char/en
https://www.proquest.com/docview/2576657515
https://pubmed.ncbi.nlm.nih.gov/PMC8636886
Volume 83
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