Establishing, maintaining and modifying DNA methylation patterns in plants and animals

• Published in: Nature reviews. Genetics Vol. 11; no. 3; pp. 204 - 220
• Main Authors: Law, Julie A., Jacobsen, Steven E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2010; Nature Publishing Group
• Subjects: 631/208/176/1988; Agriculture; Animal Genetics and Genomics; Animals; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; CpG Islands; DNA damage; DNA glycosylases; DNA methylation; DNA Methylation - genetics; DNA Methylation - physiology; DNA, Plant - genetics; DNA, Plant - metabolism; Epigenesis, Genetic; Epigenetics; Fundamental and applied biological sciences. Psychology; Gametogenesis - genetics; Gene Function; Genes; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Histones - genetics; Histones - metabolism; Human Genetics; Models, Genetic; Physiological aspects; Plants - genetics; Plants - metabolism; Proteins; review-article; RNA polymerase; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; X chromosome; United States; Los Angeles California; United States > US; California; Methylation pattern; Plant; Vegetals; Review; Animal; DNA

Key Points Recent studies have shown that RNA-directed DNA methylation (RdDM) in Arabidopsis thaliana not only requires the production of 24-nucleotide small interfering RNAs (siRNAs) and the de novo DNA methyltransferase DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) but also requires the production...