GRIM-19, a Cell Death Regulatory Protein, Is Essential for Assembly and Function of Mitochondrial Complex I

Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from...

Full description

Saved in:
Bibliographic Details
Published inMolecular and Cellular Biology Vol. 24; no. 19; pp. 8447 - 8456
Main Authors Huang, Guochang, Lu, Hao, Hao, Aijun, Ng, Dominic C. H., Ponniah, Sathivel, Guo, Ke, Lufei, Chengchen, Zeng, Qi, Cao, Xinmin
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.10.2004
Taylor & Francis
Subjects
Animals
Apoptosis - genetics
Apoptosis - physiology
Blastocyst - pathology
Cell Division - genetics
Cell Division - physiology
Cell Growth and Development
Electron Transport Complex I - metabolism
Mice
Mice, Knockout
Microscopy, Confocal
Mitochondria - metabolism
Mitochondria - pathology
NADH, NADPH Oxidoreductases - deficiency
NADH, NADPH Oxidoreductases - genetics
NADH, NADPH Oxidoreductases - metabolism
Sequence Deletion
Online AccessGet full text

Cover

Abstract Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
AbstractList Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
Mitochondria play essential roles in cellular energy production via the oxidative phosphorylation system (OXPHOS) consisting of five multiprotein complexes and also in the initiation of apoptosis. NADH:ubiquinone oxidoreductase (complex I) is the largest complex that catalyzes the first step of electron transfer in the OXPHOS system. GRIM-19 was originally identified as a nuclear protein with apoptotic nature in interferon (IFN)- and all- trans -retinoic acid (RA)-induced tumor cells. To reveal its biological role, we generated mice deficient in GRIM-19 by gene targeting. Homologous deletion of GRIM-19 causes embryonic lethality at embryonic day 9.5. GRIM-19 −/− blastocysts show retarded growth in vitro and, strikingly, display abnormal mitochondrial structure, morphology, and cellular distribution. We reexamined the cellular localization of GRIM-19 in various cell types and found its primary localization in the mitochondria. Furthermore, GRIM-19 is detected in the native form of mitochondrial complex I. Finally, we show that elimination of GRIM-19 destroys the assembly and electron transfer activity of complex I and also influences the other complexes in the mitochondrial respiratory chain. Our result demonstrates that GRIM-19, a gene product with a specific role in IFN-RA-induced cell death, is a functional component of mitochondrial complex I and is essential for early embryonic development.
Mitochondria play essential roles in cellular energy production via the oxidative phosphorylation system (OXPHOS) consisting of five multiprotein complexes and also in the initiation of apoptosis. NADH:ubiquinone oxidoreductase (complex I) is the largest complex that catalyzes the first step of electron transfer in the OXPHOS system. GRIM-19 was originally identified as a nuclear protein with apoptotic nature in interferon (IFN)- and all-trans- retinoic acid (RA)-induced tumor cells. To reveal its biological role, we generated mice deficient in GRIM-19 by gene targeting. Homologous deletion of GRIM-19 causes embryonic lethality at embryonic day 9.5. GRIM-19 super(-/-) blastocysts show retarded growth in vitro and, strikingly, display abnormal mitochondrial structure, morphology, and cellular distribution. We reexamined the cellular localization of GRIM-19 in various cell types and found its primary localization in the mitochondria. Furthermore, GRIM-19 is detected in the native form of mitochondrial complex I. Finally, we show that elimination of GRIM-19 destroys the assembly and electron transfer activity of complex I and also influences the other complexes in the mitochondrial respiratory chain. Our result demonstrates that GRIM-19, a gene product with a specific role in IFN-RA- induced cell death, is a functional component of mitochondrial complex I and is essential for early embryonic development.
Mitochondria play essential roles in cellular energy production via the oxidative phosphorylation system (OXPHOS) consisting of five multiprotein complexes and also in the initiation of apoptosis. NADH:ubiquinone oxidoreductase (complex I) is the largest complex that catalyzes the first step of electron transfer in the OXPHOS system. GRIM-19 was originally identified as a nuclear protein with apoptotic nature in interferon (IFN)- and all-trans-retinoic acid (RA)-induced tumor cells. To reveal its biological role, we generated mice deficient in GRIM-19 by gene targeting. Homologous deletion of GRIM-19 causes embryonic lethality at embryonic day 9.5. GRIM-19(-/-) blastocysts show retarded growth in vitro and, strikingly, display abnormal mitochondrial structure, morphology, and cellular distribution. We reexamined the cellular localization of GRIM-19 in various cell types and found its primary localization in the mitochondria. Furthermore, GRIM-19 is detected in the native form of mitochondrial complex I. Finally, we show that elimination of GRIM-19 destroys the assembly and electron transfer activity of complex I and also influences the other complexes in the mitochondrial respiratory chain. Our result demonstrates that GRIM-19, a gene product with a specific role in IFN-RA-induced cell death, is a functional component of mitochondrial complex I and is essential for early embryonic development.
Mitochondria play essential roles in cellular energy production via the oxidative phosphorylation system (OXPHOS) consisting of five multiprotein complexes and also in the initiation of apoptosis. NADH:ubiquinone oxidoreductase (complex I) is the largest complex that catalyzes the first step of electron transfer in the OXPHOS system. GRIM-19 was originally identified as a nuclear protein with apoptotic nature in interferon (IFN)- and all-trans-retinoic acid (RA)-induced tumor cells. To reveal its biological role, we generated mice deficient in GRIM-19 by gene targeting. Homologous deletion of GRIM-19 causes embryonic lethality at embryonic day 9.5. GRIM-19 −/− blastocysts show retarded growth in vitro and, strikingly, display abnormal mitochondrial structure, morphology, and cellular distribution. We reexamined the cellular localization of GRIM-19 in various cell types and found its primary localization in the mitochondria. Furthermore, GRIM-19 is detected in the native form of mitochondrial complex I. Finally, we show that elimination of GRIM-19 destroys the assembly and electron transfer activity of complex I and also influences the other complexes in the mitochondrial respiratory chain. Our result demonstrates that GRIM-19, a gene product with a specific role in IFN-RA-induced cell death, is a functional component of mitochondrial complex I and is essential for early embryonic development.
Author Ke Guo
Chengchen Lufei
Aijun Hao
Hao Lu
Xinmin Cao
Dominic C. H. Ng
Sathivel Ponniah
Guochang Huang
Qi Zeng
AuthorAffiliation Signal Transduction Laboratory, 1 In Vivo Model Systems Facility, 2 Histology Unit, Institute of Molecular and Cell Biology, Singapore, Republic of Singapore 3
AuthorAffiliation_xml – name: Signal Transduction Laboratory, 1 In Vivo Model Systems Facility, 2 Histology Unit, Institute of Molecular and Cell Biology, Singapore, Republic of Singapore 3
Author_xml – sequence: 1
  givenname: Guochang
  surname: Huang
  fullname: Huang, Guochang
  organization: Signal Transduction Laboratory
– sequence: 2
  givenname: Hao
  surname: Lu
  fullname: Lu, Hao
  organization: Signal Transduction Laboratory
– sequence: 3
  givenname: Aijun
  surname: Hao
  fullname: Hao, Aijun
  organization: Signal Transduction Laboratory
– sequence: 4
  givenname: Dominic C. H.
  surname: Ng
  fullname: Ng, Dominic C. H.
  organization: Signal Transduction Laboratory
– sequence: 5
  givenname: Sathivel
  surname: Ponniah
  fullname: Ponniah, Sathivel
  organization: In Vivo Model Systems Facility
– sequence: 6
  givenname: Ke
  surname: Guo
  fullname: Guo, Ke
  organization: Histology Unit, Institute of Molecular and Cell Biology, Singapore
– sequence: 7
  givenname: Chengchen
  surname: Lufei
  fullname: Lufei, Chengchen
  organization: Signal Transduction Laboratory
– sequence: 8
  givenname: Qi
  surname: Zeng
  fullname: Zeng, Qi
  organization: Histology Unit, Institute of Molecular and Cell Biology, Singapore
– sequence: 9
  givenname: Xinmin
  surname: Cao
  fullname: Cao, Xinmin
  email: mcbcaoxm@imcb.a-star.edu.sg
  organization: Signal Transduction Laboratory
BackLink https://www.ncbi.nlm.nih.gov/pubmed/15367666$$D View this record in MEDLINE/PubMed
BookMark eNqNkc1u1DAURi1URKeFV0AWC1bNYMeOfxYsSmjLSB2BKlhbjmNPDIk92BnaefsmmhGUFaysK5_v3mufM3ASYrAAQIyWGJfi3br-sCzpEsuloJQXglZsWSJEn4EFRlIUVUXlCVigkqOCE8ROwVnO3xFCTCLyApziijDOGFuAHzd3q3WB5QXUsLZ9Dz9aPXbwzm52vR5j2sMvKY7Whwu4yvAqZxtGr3voYoKXUzU0_R7q0MLrXTCjjwFGB9d-jKaLoU0zWsdh29sHuHoJnjvdZ_vqeJ6Db9dXX-tPxe3nm1V9eVsYVtGxMIZQZ5qydbolCDlOiHOIO8q4FQJLbA2TpqGtbqgUojVS86apKNYtQtgRcg7eH_pud81gWzOtnHSvtskPOu1V1F79fRN8pzbxl6ow45WY8m-P-RR_7mwe1eCzmT5HBxt3WTEmuJQE_RPEvOScUTaB4gCaFHNO1v1eBiM1G1WTUVVShaWajarZqJqNTtHXTx_zJ3hUOAH1AfBhkjLo-5j6Vo1638fkkg7GZ0X-Y8ybQ5fOb7p7n6zSeVCDaZ7g5BGXgsCj
CitedBy_id crossref_primary_10_1016_j_biocel_2007_08_015
crossref_primary_10_1007_s12032_012_0234_8
crossref_primary_10_1016_j_bbamcr_2008_04_015
crossref_primary_10_1016_j_mitoco_2024_01_001
crossref_primary_10_1074_jbc_M110_105767
crossref_primary_10_1093_hmg_ddv133
crossref_primary_10_3390_genes9050243
crossref_primary_10_1186_s12864_024_10532_7
crossref_primary_10_1371_journal_pone_0087951
crossref_primary_10_2353_ajpath_2010_091280
crossref_primary_10_1016_j_semcdb_2008_12_014
crossref_primary_10_1016_j_bbabio_2008_04_005
crossref_primary_10_3390_microorganisms10081526
crossref_primary_10_1111_j_1365_2958_2009_06643_x
crossref_primary_10_1007_s00428_009_0766_2
crossref_primary_10_1038_s41467_017_01970_x
crossref_primary_10_1016_j_fsi_2012_11_017
crossref_primary_10_1016_j_jprot_2010_12_012
crossref_primary_10_1016_j_fertnstert_2014_10_012
crossref_primary_10_1128_MCB_01946_06
crossref_primary_10_1089_ars_2009_2743
crossref_primary_10_1016_j_bbabio_2004_12_003
crossref_primary_10_1016_j_bbadis_2024_167063
crossref_primary_10_1038_sj_bjc_6602556
crossref_primary_10_1016_j_cellsig_2011_03_004
crossref_primary_10_1016_j_cyto_2010_03_009
crossref_primary_10_1016_j_mito_2012_07_106
crossref_primary_10_3390_cells10010162
crossref_primary_10_3109_14397595_2015_1101211
crossref_primary_10_1071_RD16104
crossref_primary_10_1007_s11033_010_0519_y
crossref_primary_10_1002_elps_200600049
crossref_primary_10_1016_j_cytogfr_2016_09_001
crossref_primary_10_1210_en_2018_00451
crossref_primary_10_1126_science_1164551
crossref_primary_10_1586_14789450_2_4_541
crossref_primary_10_1042_BST20130091
crossref_primary_10_1007_s10545_006_0362_4
crossref_primary_10_3390_ijms21144962
crossref_primary_10_1016_j_nbd_2011_07_011
crossref_primary_10_1371_journal_pone_0162928
crossref_primary_10_1111_j_1349_7006_2011_02059_x
crossref_primary_10_1111_jcmm_13432
crossref_primary_10_1074_jbc_M112_440610
crossref_primary_10_1038_onc_2013_271
crossref_primary_10_1091_mbc_e07_07_0683
crossref_primary_10_1002_pmic_200600801
crossref_primary_10_1096_fj_202101074RR
crossref_primary_10_1021_acs_est_8b00149
crossref_primary_10_1128_MCB_01551_13
crossref_primary_10_3390_life10110296
crossref_primary_10_32607_actanaturae_25442
crossref_primary_10_3389_fendo_2021_691979
crossref_primary_10_1016_j_biocontrol_2010_07_009
crossref_primary_10_4161_jkst_22366
crossref_primary_10_1007_s12032_012_0249_1
crossref_primary_10_1016_j_ceb_2005_09_001
crossref_primary_10_1038_jhg_2010_57
crossref_primary_10_1007_s10815_014_0413_y
crossref_primary_10_3892_mmr_2015_4393
crossref_primary_10_1371_journal_pone_0153659
crossref_primary_10_1016_j_bbabio_2007_07_008
crossref_primary_10_1128_MCB_00497_06
crossref_primary_10_1016_j_dci_2013_11_004
crossref_primary_10_3340_jkns_2010_48_1_20
crossref_primary_10_1007_s11064_011_0689_6
crossref_primary_10_1002_ibd_20313
crossref_primary_10_1016_j_celrep_2014_06_018
crossref_primary_10_1371_journal_pone_0000098
crossref_primary_10_1038_sj_onc_1209708
crossref_primary_10_1016_j_rbmo_2016_10_001
crossref_primary_10_1089_ars_2019_7918
crossref_primary_10_18632_oncotarget_9167
crossref_primary_10_1007_s10863_009_9252_4
crossref_primary_10_1007_s10571_019_00689_1
crossref_primary_10_1016_j_ctrv_2007_11_003
crossref_primary_10_1016_j_fsi_2015_12_016
crossref_primary_10_1126_science_1142984
crossref_primary_10_1007_s10495_010_0527_3
crossref_primary_10_1016_j_aquatox_2018_10_023
crossref_primary_10_5402_2012_217162
crossref_primary_10_1016_j_bbabio_2010_03_013
crossref_primary_10_1016_j_neuroscience_2019_11_015
crossref_primary_10_1016_j_yexcr_2010_05_010
crossref_primary_10_1016_j_redox_2018_101073
crossref_primary_10_1158_0008_5472_CAN_07_0031
crossref_primary_10_1126_science_1169660
crossref_primary_10_1016_j_mam_2009_08_002
crossref_primary_10_3390_v15122380
crossref_primary_10_1007_s10120_020_01111_2
crossref_primary_10_1007_s13365_016_0506_8
crossref_primary_10_1074_jbc_M413776200
crossref_primary_10_1016_j_scr_2015_10_015
crossref_primary_10_1016_j_tcb_2012_05_001
crossref_primary_10_1134_S0006297916100072
crossref_primary_10_1146_annurev_biochem_75_103004_142539
crossref_primary_10_1016_j_ymgme_2011_11_188
crossref_primary_10_1038_sj_cdd_4402004
crossref_primary_10_1074_jbc_M609410200
crossref_primary_10_1136_jcp_2008_055343
crossref_primary_10_3389_fgene_2015_00206
crossref_primary_10_1016_j_freeradbiomed_2023_03_024
crossref_primary_10_1016_j_jdermsci_2010_12_003
crossref_primary_10_1016_j_jbc_2023_104727
crossref_primary_10_1016_j_cyto_2013_12_006
crossref_primary_10_3389_fcimb_2022_1016299
crossref_primary_10_3390_cells10071625
crossref_primary_10_1016_j_mito_2011_05_011
crossref_primary_10_58502_DTT_23_0013
crossref_primary_10_1038_s42003_023_04533_7
crossref_primary_10_1161_JAHA_122_028023
crossref_primary_10_3389_fendo_2022_1023194
crossref_primary_10_1007_s13277_016_4877_5
crossref_primary_10_3892_mmr_2015_3757
crossref_primary_10_1016_j_ejcb_2012_09_002
crossref_primary_10_1111_j_1349_7006_2006_00383_x
crossref_primary_10_1016_j_lfs_2012_06_041
crossref_primary_10_1097_PAP_0b013e31815e5258
crossref_primary_10_3389_fonc_2015_00121
crossref_primary_10_1007_s00726_010_0824_8
crossref_primary_10_1007_s00726_010_0517_3
crossref_primary_10_1530_ERC_11_0354
crossref_primary_10_1073_pnas_1303760110
crossref_primary_10_1158_1535_7163_MCT_09_1147
crossref_primary_10_1016_j_bbabio_2008_12_018
crossref_primary_10_1038_sj_bjc_6602547
crossref_primary_10_1074_jbc_M111_226209
crossref_primary_10_3389_fcvm_2015_00036
crossref_primary_10_1016_j_bbabio_2010_10_023
crossref_primary_10_1534_genetics_105_041517
crossref_primary_10_1016_j_modgep_2006_09_005
crossref_primary_10_1042_BJ20091213
crossref_primary_10_1007_s10741_010_9170_x
crossref_primary_10_1074_jbc_M112_378984
crossref_primary_10_1186_s12967_016_0963_0
crossref_primary_10_1093_nar_gkt132
crossref_primary_10_2174_2589977512666200220122650
crossref_primary_10_1038_sj_cdd_4402291
crossref_primary_10_1002_pmic_200600728
crossref_primary_10_1016_j_jbc_2022_102671
crossref_primary_10_1074_jbc_M112_340315
crossref_primary_10_1016_j_semcancer_2017_06_014
crossref_primary_10_1007_s40618_015_0356_x
crossref_primary_10_1089_jir_2006_0067
crossref_primary_10_1093_hmg_ddm371
crossref_primary_10_1016_j_canlet_2016_01_036
crossref_primary_10_1111_j_1471_4159_2007_05123_x
crossref_primary_10_1128_JVI_01156_07
crossref_primary_10_1007_s00425_018_3065_9
crossref_primary_10_3389_fonc_2017_00118
crossref_primary_10_1089_jir_2014_0021
crossref_primary_10_1016_j_neuint_2017_05_003
crossref_primary_10_1177_039463200702000407
crossref_primary_10_1016_j_yexcr_2012_07_012
crossref_primary_10_1016_S1472_6483_10_60050_8
crossref_primary_10_1038_s41575_024_00931_2
crossref_primary_10_4110_in_2020_20_e40
crossref_primary_10_1182_blood_2009_10_246439
crossref_primary_10_1016_j_yexcr_2021_112799
crossref_primary_10_1152_ajplung_00037_2018
crossref_primary_10_1093_molehr_gay020
crossref_primary_10_1152_ajpgi_00462_2014
crossref_primary_10_1042_BSR20171038
Cites_doi 10.1042/bj3420249
10.1074/jbc.C300064200
10.1126/science.8197455
10.1074/jbc.M304998200
10.1016/S0955-0674(00)00199-X
10.1146/annurev.biophys.30.1.23
10.1074/mcp.M300014-MCP200
10.1128/MCB.18.11.6493
10.1146/annurev.biochem.67.1.227
10.1016/S0005-2728(03)00059-8
10.1016/0955-0674(94)90051-5
10.1126/science.283.5407.1488
10.1093/emboj/19.8.1777
10.1158/0008-5472.CAN-03-3443
10.1016/S0014-5793(98)01317-9
10.1017/S003358350000425X
10.1128/MCB.23.19.6790-6797.2003
10.1016/S1385-299X(01)00108-8
10.1006/abio.1994.1112
10.1002/elps.1150181131
10.1016/0003-2697(91)90094-A
10.1074/jbc.M003929200
10.1074/jbc.C100444200
10.1002/ajmg.1397
10.1111/j.1432-1033.1991.tb15945.x
10.1101/gr.10.5.703
10.1016/S0092-8674(00)80849-1
10.1016/S0092-8674(03)00116-8
10.1016/0092-8674(94)90235-6
10.1146/annurev.bi.54.070185.005055
10.1073/pnas.1633516100
10.1126/science.283.5407.1482
10.1002/ajmg.1427
10.1093/emboj/cdg135
10.1016/S0005-2728(98)00023-1
ContentType Journal Article
Copyright Copyright © 2004, American Society for Microbiology 2004
Copyright_xml – notice: Copyright © 2004, American Society for Microbiology 2004
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
8FD
FR3
P64
RC3
7X8
5PM
DOI 10.1128/MCB.24.19.8447-8456.2004
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Technology Research Database
Engineering Research Database
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Genetics Abstracts
Engineering Research Database
Technology Research Database
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
DatabaseTitleList

Genetics Abstracts
MEDLINE

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
Biology
EISSN 1098-5549
EndPage 8456
ExternalDocumentID 10_1128_MCB_24_19_8447_8456_2004
15367666
12268277
mcb_24_19_8447
Genre Cell Growth and Development
Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-DZ
-~X
.55
.GJ
0R~
123
18M
29M
2WC
39C
3O-
4.4
53G
5RE
5VS
9M8
AAPBV
AAUGY
ABPTK
ACGFO
ACKIV
ACNCT
ADBBV
ADIYS
AENEX
AFFNX
AGVNZ
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CS3
DIK
DU5
E3Z
EBS
EJD
F5P
GX1
H13
HH5
HYE
HZ~
IH2
KQ8
L7B
MVM
N9A
O9-
OK1
P2P
RHF
RHI
RNS
RPM
RSF
TFL
TFW
TR2
UCJ
UDS
VQA
W8F
WH7
WHG
WOQ
X7M
Y6R
ZA5
ZCA
ZGI
ABJNI
ABRLO
ABTAH
AEOZL
AGHSJ
CGR
CUY
CVF
ECM
EIF
EMOBN
F20
M4Z
NPM
TDBHL
YYP
ZXP
ZY4
AAYXX
CITATION
8FD
FR3
P64
RC3
7X8
5PM
ID FETCH-LOGICAL-c654t-cc34fcb2dfad300f733ff07f467e88191ec69cb4dab4988dc9a7bb541ad001f33
IEDL.DBID RPM
ISSN 0270-7306
1098-5549
IngestDate Tue Sep 17 21:01:10 EDT 2024
Fri Oct 25 23:47:41 EDT 2024
Fri Oct 25 22:48:13 EDT 2024
Fri Dec 06 05:33:12 EST 2024
Sat Sep 28 07:47:08 EDT 2024
Tue Jun 13 19:24:49 EDT 2023
Wed May 18 15:26:10 EDT 2016
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 19
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c654t-cc34fcb2dfad300f733ff07f467e88191ec69cb4dab4988dc9a7bb541ad001f33
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Corresponding author. Mailing address: Institute of Molecular and Cell Biology, Proteos Building, Room 6-19B, 61 Biopolis Dr., Singapore 138673, Republic of Singapore. Phone: 65 6586 9657. Fax: 65 6779 1117. E-mail: mcbcaoxm@imcb.a-star.edu.sg.
OpenAccessLink https://mcb.asm.org/content/mcb/24/19/8447.full.pdf
PMID 15367666
PQID 17277646
PQPubID 23462
PageCount 10
ParticipantIDs proquest_miscellaneous_66879930
crossref_primary_10_1128_MCB_24_19_8447_8456_2004
highwire_asm_mcb_24_19_8447
informaworld_taylorfrancis_310_1128_MCB_24_19_8447_8456_2004
pubmedcentral_primary_oai_pubmedcentral_nih_gov_516758
pubmed_primary_15367666
proquest_miscellaneous_17277646
PublicationCentury 2000
PublicationDate 20041001
10/1/2004
2004-Oct
2004-10-01
PublicationDateYYYYMMDD 2004-10-01
PublicationDate_xml – month: 10
  year: 2004
  text: 20041001
  day: 01
PublicationDecade 2000
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Molecular and Cellular Biology
PublicationTitleAlternate Mol Cell Biol
PublicationYear 2004
Publisher American Society for Microbiology
Taylor & Francis
Publisher_xml – name: American Society for Microbiology
– name: Taylor & Francis
References 12628925 - EMBO J. 2003 Mar 17;22(6):1325-35
10455009 - Biochem J. 1999 Sep 1;342 ( Pt 2):249-68
1812789 - Anal Biochem. 1991 Dec;199(2):223-31
11579423 - Am J Med Genet. 2001 Spring;106(1):37-45
12644575 - Mol Cell Proteomics. 2003 Feb;2(2):117-26
12611891 - J Biol Chem. 2003 Apr 18;278(16):13619-22
10924506 - J Biol Chem. 2000 Oct 27;275(43):33416-26
11733193 - Brain Res Brain Res Protoc. 2001 Dec;8(3):176-83
9420170 - Electrophoresis. 1997 Oct;18(11):2059-64
10775262 - EMBO J. 2000 Apr 17;19(8):1777-83
12867595 - Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9342-7
9815768 - Clin Cancer Res. 1997 Jun;3(6):931-7
10830166 - Cell. 2000 May 12;101(4):389-99
8203750 - Anal Biochem. 1994 Mar;217(2):220-30
10066163 - Science. 1999 Mar 5;283(5407):1488-93
7512451 - Cell. 1994 Apr 8;77(1):63-71
11248555 - Curr Opin Cell Biol. 2001 Apr;13(2):211-7
9759489 - Annu Rev Biochem. 1998;67:227-64
9593856 - Biochim Biophys Acta. 1998 May 6;1364(2):125-33
12837546 - Biochim Biophys Acta. 2003 Jul 10;1604(3):135-50
1470679 - Q Rev Biophys. 1992 Aug;25(3):253-324
8197455 - Science. 1994 Jun 3;264(5164):1415-21
7831583 - Semin Hematol. 1994 Oct;31(4 Suppl 5):31-7
10066162 - Science. 1999 Mar 5;283(5407):1482-8
10810093 - Genome Res. 2000 May;10(5):703-13
12972599 - Mol Cell Biol. 2003 Oct;23(19):6790-7
11579419 - Am J Med Genet. 2001 Spring;106(1):1-3
12941961 - J Biol Chem. 2003 Oct 31;278(44):43081-8
11340051 - Annu Rev Biophys Biomol Struct. 2001;30:23-65
11522775 - J Biol Chem. 2001 Oct 19;276(42):38345-8
12600312 - Cell. 2003 Feb 21;112(4):481-90
9774665 - Mol Cell Biol. 1998 Nov;18(11):6493-504
9827566 - FEBS Lett. 1998 Nov 6;438(3):301-5
2029890 - Eur J Biochem. 1991 May 8;197(3):563-76
2862839 - Annu Rev Biochem. 1985;54:1015-69
15059901 - Cancer Res. 2004 Apr 1;64(7):2474-81
7880529 - Curr Opin Cell Biol. 1994 Dec;6(6):825-31
Lindner D. J. (R15) 1997; 3
Yagi T. (R34) 1998; 1364
R21
R20
R23
R22
R25
R24
R27
Skehel J. M. (R28) 1998; 438
R26
R29
Lykke-Andersen K. (R18) 2003; 23
R1
R2
R3
R4
Moore D. M. (R19) 1994; 31
R6
R7
R8
R9
R30
R10
R32
R31
R12
R11
R33
R14
R36
Dahl H. H. (R5) 2001; 106
R13
R35
R16
R37
R17
References_xml – ident: R6
  doi: 10.1042/bj3420249
– ident: R20
  doi: 10.1074/jbc.C300064200
– ident: R7
  doi: 10.1126/science.8197455
– ident: R3
  doi: 10.1074/jbc.M304998200
– ident: R12
  doi: 10.1016/S0955-0674(00)00199-X
– ident: R27
  doi: 10.1146/annurev.biophys.30.1.23
– ident: R4
  doi: 10.1074/mcp.M300014-MCP200
– ident: R11
  doi: 10.1128/MCB.18.11.6493
– ident: R29
  doi: 10.1146/annurev.biochem.67.1.227
– ident: R10
  doi: 10.1016/S0005-2728(03)00059-8
– ident: R16
  doi: 10.1016/0955-0674(94)90051-5
– ident: R23
  doi: 10.1126/science.283.5407.1488
– ident: R24
  doi: 10.1093/emboj/19.8.1777
– ident: R37
  doi: 10.1158/0008-5472.CAN-03-3443
– volume: 438
  start-page: 301
  year: 1998
  ident: R28
  publication-title: FEBS Lett.
  doi: 10.1016/S0014-5793(98)01317-9
  contributor:
    fullname: Skehel J. M.
– volume: 3
  start-page: 931
  year: 1997
  ident: R15
  publication-title: Clin. Cancer Res.
  contributor:
    fullname: Lindner D. J.
– ident: R31
  doi: 10.1017/S003358350000425X
– volume: 31
  start-page: 31
  year: 1994
  ident: R19
  publication-title: Semin. Hematol.
  contributor:
    fullname: Moore D. M.
– volume: 23
  start-page: 6790
  year: 2003
  ident: R18
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.23.19.6790-6797.2003
  contributor:
    fullname: Lykke-Andersen K.
– ident: R22
  doi: 10.1016/S1385-299X(01)00108-8
– ident: R26
  doi: 10.1006/abio.1994.1112
– ident: R35
  doi: 10.1002/elps.1150181131
– ident: R25
  doi: 10.1016/0003-2697(91)90094-A
– ident: R2
  doi: 10.1074/jbc.M003929200
– ident: R8
  doi: 10.1074/jbc.C100444200
– ident: R30
  doi: 10.1002/ajmg.1397
– ident: R33
  doi: 10.1111/j.1432-1033.1991.tb15945.x
– ident: R13
  doi: 10.1101/gr.10.5.703
– ident: R14
  doi: 10.1016/S0092-8674(00)80849-1
– ident: R21
  doi: 10.1016/S0092-8674(03)00116-8
– ident: R1
  doi: 10.1016/0092-8674(94)90235-6
– ident: R9
  doi: 10.1146/annurev.bi.54.070185.005055
– ident: R36
  doi: 10.1073/pnas.1633516100
– ident: R32
  doi: 10.1126/science.283.5407.1482
– volume: 106
  start-page: 1
  year: 2001
  ident: R5
  publication-title: Am. J. Med. Genet.
  doi: 10.1002/ajmg.1427
  contributor:
    fullname: Dahl H. H.
– ident: R17
  doi: 10.1093/emboj/cdg135
– volume: 1364
  start-page: 125
  year: 1998
  ident: R34
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/S0005-2728(98)00023-1
  contributor:
    fullname: Yagi T.
SSID ssj0006903
Score 2.2913935
Snippet Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
Mitochondria play essential roles in cellular energy production via the oxidative phosphorylation system (OXPHOS) consisting of five multiprotein complexes and...
SourceID pubmedcentral
proquest
crossref
pubmed
informaworld
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 8447
SubjectTerms Animals
Apoptosis - genetics
Apoptosis - physiology
Blastocyst - pathology
Cell Division - genetics
Cell Division - physiology
Cell Growth and Development
Electron Transport Complex I - metabolism
Mice
Mice, Knockout
Microscopy, Confocal
Mitochondria - metabolism
Mitochondria - pathology
NADH, NADPH Oxidoreductases - deficiency
NADH, NADPH Oxidoreductases - genetics
NADH, NADPH Oxidoreductases - metabolism
Sequence Deletion
Title GRIM-19, a Cell Death Regulatory Protein, Is Essential for Assembly and Function of Mitochondrial Complex I
URI http://mcb.asm.org/content/24/19/8447.abstract
https://www.tandfonline.com/doi/abs/10.1128/MCB.24.19.8447-8456.2004
https://www.ncbi.nlm.nih.gov/pubmed/15367666
https://search.proquest.com/docview/17277646
https://search.proquest.com/docview/66879930
https://pubmed.ncbi.nlm.nih.gov/PMC516758
Volume 24
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFLXoJAQvaIyvMBh-4HFp49hxEokXCCsrKGhMTNqb5Ti2VpG409JJ67_n2kmgm0BIPMeJmp7Te8-tr89F6G1upKE6ykOZEhMynZgw11qHJkpTSMdaST-tofzKj8_Y5_PkfDgU1g1tlVZVy6lt2qldXvjeystWzcY-sdlJWSTEydzZBE0g-44V-hB9odrzu8pxGoXAXj5278TZrCw-TGM2JcAOxiA2g3bwBaIfzeOcy7xV4lZ2Gh2D79iY_kmM3u2p3EpS8130aFCX-H3_Fo_RPW330P1-3uRmDz0oxvFuT9CPT6eLMiT5IZa40E2DPzoxiE_72fSrqw0-cRYOS3uIFx0-6twhJeAqhg-I3U5xWzUbLG2N55AZHbp4ZXAJ8QHiqa0drbGLNY2-wYun6Gx-9L04DofJC6HiCVuHSlFmVBXXRtY0ikxKqQH0DERVnbkSTyueq4rVsmJ5ltUql2lVJYzIGtKeofQZ2rErq18gDPLHWdoTE9VQecZEEsk0pTHwgxIdJwEi4zcuLnuDDeELkzgTAJiImSC5cIAJB5gbm8kCtD9CI2TXilZVW-sC9G4bLbH2f32Yfk6JoP9--JsRXQGQuP0TafXquhNO66Wc8b-v4DxLQfBFAXres-H3Kw0ECxC_xZNfC5zN9-0rwH5v992z_eX_3riPHvbmlK4B8RXaWV9d69cgpNbVAZp8-ZYd-N_PT1GAGec
link.rule.ids 230,314,727,780,784,885,27924,27925,53791,53793
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFLVgCI0XNAaMsMH8wOPSxrHzJfHCwkoLyzRNm7Q3y3FsUZG409JJ67_ftZOMbgIh8RwnanpO7z23vj4XoU-ZFpqqIPNFQrTPVKT9TCnl6yBJIB0rKdy0huIknl6w75fRZX8orO3bKo0s5yNTNyMz_-l6K68aOR76xManRR4RK3PHT9GziCYZGWr0Pv5Cvef2lcMk8IG_8dC_E6bjIj8chWxEgB-MQXQG9eBKRDecx3qXObPEtfw0eAY_MjL9kxx93FW5lqYmW-hlry_xl-49XqEnymyj593EydU22syHAW-v0a9vZ7PCJ9kBFjhXdY2_WjmIz7rp9IvrFT61Jg5zc4BnLT5q7TElYCuGD4jtXnFT1issTIUnkBstvnihcQERAiKqqSyxsY02tbrFszfoYnJ0nk_9fvaCL-OILX0pKdOyDCstKhoEOqFUA34a4qpKbZGnZJzJklWiZFmaVjITSVlGjIgKEp-m9C3aMAuj3iEMAsia2hMdVFB7hkQQwRSlITCEEhVGHiLDN86vOosN7kqTMOUAGA8ZJxm3gHELmB2cyTy0O0DDRdvwRpZr6zz0eR0tvnR_fuhuUgmn_374_oAuB0jsDoowanHTcqv2kpjFf18Rx2kCki_w0E7Hht-v1BPMQ_EDntwvsEbfD68A_53hd8f39_974z7anJ4Xx_x4dvJjF73orCptO-Ie2lhe36gPIKuW5Uf3K7oDprAcRw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9NAEB2VIj4uCAoFU6B74FjHXu_6S-ICbkMDuIoqKvW2Wq93RYTtRE0qkX_P7DqGtAIhcfY6iv2eZ954x28A3uZGGqbD3JcpNT7XsfFzrbVvwjTFdKyVdNMayrPk9IJ_uowvdyAbvoVxTfuqmo26ph11s2-ut3LRqmDoEwumZRFTK3ODRW2CO3A3ZsixoU7fxGCs-dzecpSGPnI4GXp4oiwoiw-jiI8ocoRzjNCoIFyZ6Ab0WP8yZ5i4laMG3-BbZqZ_kqS3Oyu3UtX4MTzaaEzyvr-WJ7Cjuz2410-dXO_Bg2IY8vYUvn88n5Q-zY-IJIVuGnJsJSE57yfUz6_WZGqNHGbdEZksycnSfqqEjCX4B4ndL26rZk1kV5Mx5keLMZkbUmKUwKja1ZbcxEacRv8gk2dwMT75Wpz6m_kLvkpivvKVYtyoKqqNrFkYmpQxgxgajK06s4WeVkmuKl7LiudZVqtcplUVcyprTH6GsX3Y7eadfgEERZA1tqcmrLH-jKikkmvGImQJozqKPaDDHReL3mZDuPIkygQCJiIuaC4sYMICZodncg8OBmiEXLaiVdXWOg_ebaMlVu4FiOmnlQj27x8_HNAVCIndRZGdnl8vhVV8acKTv69IkixF2Rd68Lxnw-9L2hDMg-QGT34tsGbfN4_gM-BMv3vOv_zfEw_h_vR4LL5Mzj4fwMPerdJ2JL6C3dXVtX6NympVvXEP0U_Kbh1a
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=GRIM-19%2C+a+Cell+Death+Regulatory+Protein%2C+Is+Essential+for+Assembly+and+Function+of+Mitochondrial+Complex+I&rft.jtitle=Molecular+and+cellular+biology&rft.au=Huang%2C+Guochang&rft.au=Lu%2C+Hao&rft.au=Hao%2C+Aijun&rft.au=Ng%2C+Dominic+C.+H.&rft.date=2004-10-01&rft.issn=1098-5549&rft.eissn=1098-5549&rft.volume=24&rft.issue=19&rft.spage=8447&rft.epage=8456&rft_id=info:doi/10.1128%2FMCB.24.19.8447-8456.2004&rft.externalDBID=n%2Fa&rft.externalDocID=10_1128_MCB_24_19_8447_8456_2004
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-7306&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-7306&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-7306&client=summon