Correlation of IgA, IgM and IgG antibody-detecting assays based on filamentous haemagglutinin, pertussis toxin and Bordetella pertussis sonicate in a strictly adult population

• Published in: Epidemiology and infection Vol. 133; no. 1; pp. 149 - 158
• Main Authors: KLEMENT, E., KAGAN, N., HAGAIN, L., KAYOUF, R., BOXMAN, J., COHEN, D., ORR, N.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.02.2005
• Subjects: Adolescent; Adult; Antibodies; Antibodies, Bacterial - analysis; Antigens; Bacteriology; Biological and medical sciences; Bordetella pertussis; Bordetella pertussis - immunology; Cough; Enzyme linked immunosorbent assay; Female; Fundamental and applied biological sciences. Psychology; Hemagglutinins - immunology; Humans; Immunoglobulin A - immunology; Immunoglobulin G - immunology; Immunoglobulin M - immunology; Immunoglobulins - immunology; Infections; Male; Microbiology; Miscellaneous; Pertussis Toxin - immunology; ROC Curve; Sensitivity and Specificity; Serologic Tests - methods; Symptoms; Toxins; Vaccination; Whooping cough; Whooping Cough - diagnosis; Whooping Cough - immunology; Human; IgA; Microbiology; Antibody; Hemagglutinin; IgG; Islet activating protein; Bordetella pertussis; Epidemiology; IgM; Bacteria; Adult; Detection

Pertussis diagnosis among adults is primarily based on serology. In this study, receiver operation characteristics (ROC) analysis was utilized to evaluate three IgA, IgM and IgG ELISAs based on B. pertussis whole-cell sonicate (WC), pertussis toxin (PT), or combined PT-filamentous haemagglutinin (FH...