Elucidating the involvement of apoptosis in postmortem proteolysis in porcine muscles from two production cycles using metabolomics approach
Apoptosis has been suggested as the first step in the process of conversion of muscle into meat. While a potential role of apoptosis in postmortem proteolysis has been proposed, the underlying mechanisms by which metabolome changes in muscles would influence apoptotic and proteolytic process, leadin...
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Published in | Scientific reports Vol. 11; no. 1; p. 3465 |
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Main Authors | , , , , , , , |
Format | Journal Article |
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10.02.2021
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Abstract | Apoptosis has been suggested as the first step in the process of conversion of muscle into meat. While a potential role of apoptosis in postmortem proteolysis has been proposed, the underlying mechanisms by which metabolome changes in muscles would influence apoptotic and proteolytic process, leading to meat quality variation, has not been determined. Here, apoptotic and proteolytic attributes and metabolomics profiling of longissimus dorsi (LD) and psoas major (PM) muscles in pigs from two different production cycles (July–Jan vs. Apr–Sep) were evaluated. PM showed higher mitochondrial membrane permeability (MMP), concurrent with less extent of calpain-1 autolysis and troponin T degradation and higher abundance of HSP27 and αβ-crystallin compared to LD (P < 0.05). Apr–Sep muscles showed concurrence of extended apoptosis (indicated by higher MMP), calpain-1 autolysis and troponin T degradation, regardless of muscle effects (P < 0.05). Metabolomics profiling showed Apr–Sep muscles to increase in oxidative stress-related macronutrients, including 6-carbon sugars, some branched-chain AA, and free fatty acids. Antioxidant AA (His and Asp) and ascorbic acid were higher in July–Jan (P < 0.05). The results of the present study suggest that early postmortem apoptosis might be positively associated with pro-oxidant macronutrients and negatively associated with antioxidant metabolites, consequently affecting meat quality attributes in a muscle-specific manner. |
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AbstractList | Apoptosis has been suggested as the first step in the process of conversion of muscle into meat. While a potential role of apoptosis in postmortem proteolysis has been proposed, the underlying mechanisms by which metabolome changes in muscles would influence apoptotic and proteolytic process, leading to meat quality variation, has not been determined. Here, apoptotic and proteolytic attributes and metabolomics profiling of longissimus dorsi (LD) and psoas major (PM) muscles in pigs from two different production cycles (July–Jan vs. Apr–Sep) were evaluated. PM showed higher mitochondrial membrane permeability (MMP), concurrent with less extent of calpain-1 autolysis and troponin T degradation and higher abundance of HSP27 and αβ-crystallin compared to LD (P < 0.05). Apr–Sep muscles showed concurrence of extended apoptosis (indicated by higher MMP), calpain-1 autolysis and troponin T degradation, regardless of muscle effects (P < 0.05). Metabolomics profiling showed Apr–Sep muscles to increase in oxidative stress-related macronutrients, including 6-carbon sugars, some branched-chain AA, and free fatty acids. Antioxidant AA (His and Asp) and ascorbic acid were higher in July–Jan (P < 0.05). The results of the present study suggest that early postmortem apoptosis might be positively associated with pro-oxidant macronutrients and negatively associated with antioxidant metabolites, consequently affecting meat quality attributes in a muscle-specific manner. Abstract Apoptosis has been suggested as the first step in the process of conversion of muscle into meat. While a potential role of apoptosis in postmortem proteolysis has been proposed, the underlying mechanisms by which metabolome changes in muscles would influence apoptotic and proteolytic process, leading to meat quality variation, has not been determined. Here, apoptotic and proteolytic attributes and metabolomics profiling of longissimus dorsi (LD) and psoas major (PM) muscles in pigs from two different production cycles (July–Jan vs. Apr–Sep) were evaluated. PM showed higher mitochondrial membrane permeability (MMP), concurrent with less extent of calpain-1 autolysis and troponin T degradation and higher abundance of HSP27 and αβ-crystallin compared to LD (P < 0.05). Apr–Sep muscles showed concurrence of extended apoptosis (indicated by higher MMP), calpain-1 autolysis and troponin T degradation, regardless of muscle effects (P < 0.05). Metabolomics profiling showed Apr–Sep muscles to increase in oxidative stress-related macronutrients, including 6-carbon sugars, some branched-chain AA, and free fatty acids. Antioxidant AA (His and Asp) and ascorbic acid were higher in July–Jan (P < 0.05). The results of the present study suggest that early postmortem apoptosis might be positively associated with pro-oxidant macronutrients and negatively associated with antioxidant metabolites, consequently affecting meat quality attributes in a muscle-specific manner. |
ArticleNumber | 3465 |
Author | Lee, Choong Hwan Suh, Dong Ho Kim, Yuan H. Brad Johnson, Jay S. Duttlinger, Alan W. Ma, Danyi Chao, Yufan Zhang, Jiaying |
Author_xml | – sequence: 1 givenname: Danyi surname: Ma fullname: Ma, Danyi organization: Department of Animal Sciences, Purdue University – sequence: 2 givenname: Dong Ho surname: Suh fullname: Suh, Dong Ho organization: Department of Bioscience and Biotechnology, Konkuk University – sequence: 3 givenname: Jiaying surname: Zhang fullname: Zhang, Jiaying organization: Department of Animal Sciences, Purdue University – sequence: 4 givenname: Yufan surname: Chao fullname: Chao, Yufan organization: Department of Animal Sciences, Purdue University – sequence: 5 givenname: Alan W. surname: Duttlinger fullname: Duttlinger, Alan W. organization: Department of Animal Sciences, Purdue University, USDA-ARS Livestock Behavior Research Unit – sequence: 6 givenname: Jay S. surname: Johnson fullname: Johnson, Jay S. organization: USDA-ARS Livestock Behavior Research Unit – sequence: 7 givenname: Choong Hwan surname: Lee fullname: Lee, Choong Hwan email: chlee123@konkuk.ac.kr organization: Department of Bioscience and Biotechnology, Konkuk University, Research Institute for Bioactive-Metabolome Network, Konkuk University – sequence: 8 givenname: Yuan H. Brad surname: Kim fullname: Kim, Yuan H. Brad email: bradkim@purdue.edu organization: Department of Animal Sciences, Purdue University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33568769$$D View this record in MEDLINE/PubMed |
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Snippet | Apoptosis has been suggested as the first step in the process of conversion of muscle into meat. While a potential role of apoptosis in postmortem proteolysis... Abstract Apoptosis has been suggested as the first step in the process of conversion of muscle into meat. While a potential role of apoptosis in postmortem... |
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SubjectTerms | 631/337 631/45 631/553 631/80 Antioxidants Apoptosis Ascorbic acid Autolysis Calcium-binding protein Calpain Crystallin Fatty acids Hsp27 protein Humanities and Social Sciences Meat Meat quality Membrane permeability Metabolites Metabolomics Mitochondria multidisciplinary Muscles Oxidants Oxidative stress Oxidizing agents Proteolysis Science Science (multidisciplinary) Troponin Troponin T |
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Title | Elucidating the involvement of apoptosis in postmortem proteolysis in porcine muscles from two production cycles using metabolomics approach |
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