Estimation of inter-individual variability of protein requirement by indicator amino acid oxidation method
The indicator amino acid oxidation (IAAO) method is a recently developed method to determine the protein requirement and is particularly useful for analyzing human subjects because of its minimal invasiveness. IAAO study is performed using two-phase regression analysis, with the break-point between...
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Published in | Journal of Clinical Biochemistry and Nutrition Vol. 68; no. 1; pp. 32 - 36 |
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Abstract | The indicator amino acid oxidation (IAAO) method is a recently developed method to determine the protein requirement and is particularly useful for analyzing human subjects because of its minimal invasiveness. IAAO study is performed using two-phase regression analysis, with the break-point between these phases being the estimated average requirement. However, this method requires that the break-point lie within a certain range in advance, which is in practice difficult. Recently, the change-point regression model (CPRM) has been proposed to be more effective for two-phase regression analysis. There is also a need to re-evaluate the value corresponding to the recommended dietary allowance. Calculation of the recommended dietary allowance requires data on the average requirement and the inter-individual variability of this requirement. However, no inter-individual variability values have been reported in the IAAO method. The aim of this study was thus to estimate the inter-individual variation in protein requirement using CPRM. From seven IAAO studies, the inter-individual variability was estimated as a coefficient of variation of about 20%. The coefficient of variation of the protein requirement determined by IAAO study was wider than the ordinary coefficient of variation obtained from the nitrogen balance test. |
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AbstractList | The indicator amino acid oxidation (IAAO) method is a recently developed method to determine the protein requirement and is particularly useful for analyzing human subjects because of its minimal invasiveness. IAAO study is performed using two-phase regression analysis, with the break-point between these phases being the estimated average requirement. However, this method requires that the break-point lie within a certain range in advance, which is in practice difficult. Recently, the change-point regression model (CPRM) has been proposed to be more effective for two-phase regression analysis. There is also a need to re-evaluate the value corresponding to the recommended dietary allowance. Calculation of the recommended dietary allowance requires data on the average requirement and the inter-individual variability of this requirement. However, no inter-individual variability values have been reported in the IAAO method. The aim of this study was thus to estimate the inter-individual variation in protein requirement using CPRM. From seven IAAO studies, the inter-individual variability was estimated as a coefficient of variation of about 20%. The coefficient of variation of the protein requirement determined by IAAO study was wider than the ordinary coefficient of variation obtained from the nitrogen balance test. The indicator amino acid oxidation (IAAO) method is a recently developed method to determine the protein requirement and is particularly useful for analyzing human subjects because of its minimal invasiveness. IAAO study is performed using two-phase regression analysis, with the break-point between these phases being the estimated average requirement. However, this method requires that the break-point lie within a certain range in advance, which is in practice difficult. Recently, the change-point regression model (CPRM) has been proposed to be more effective for two-phase regression analysis. There is also a need to re-evaluate the value corresponding to the recommended dietary allowance. Calculation of the recommended dietary allowance requires data on the average requirement and the inter-individual variability of this requirement. However, no inter-individual variability values have been reported in the IAAO method. The aim of this study was thus to estimate the inter-individual variation in protein requirement using CPRM. From seven IAAO studies, the inter-individual variability was estimated as a coefficient of variation of about 20%. The coefficient of variation of the protein requirement determined by IAAO study was wider than the ordinary coefficient of variation obtained from the nitrogen balance test.The indicator amino acid oxidation (IAAO) method is a recently developed method to determine the protein requirement and is particularly useful for analyzing human subjects because of its minimal invasiveness. IAAO study is performed using two-phase regression analysis, with the break-point between these phases being the estimated average requirement. However, this method requires that the break-point lie within a certain range in advance, which is in practice difficult. Recently, the change-point regression model (CPRM) has been proposed to be more effective for two-phase regression analysis. There is also a need to re-evaluate the value corresponding to the recommended dietary allowance. Calculation of the recommended dietary allowance requires data on the average requirement and the inter-individual variability of this requirement. However, no inter-individual variability values have been reported in the IAAO method. The aim of this study was thus to estimate the inter-individual variation in protein requirement using CPRM. From seven IAAO studies, the inter-individual variability was estimated as a coefficient of variation of about 20%. The coefficient of variation of the protein requirement determined by IAAO study was wider than the ordinary coefficient of variation obtained from the nitrogen balance test. |
Author | Hayamizu, Kohsuke Aoki, Yuma Izumo, Nobuo Nakano, Makoto |
Author_xml | – sequence: 1 fullname: Hayamizu, Kohsuke organization: Department of Pharmacy, Yokohama University of Pharmacy – sequence: 2 fullname: Aoki, Yuma organization: Department of Pharmacy, Yokohama University of Pharmacy – sequence: 3 fullname: Izumo, Nobuo organization: Department of Pharmacy, Yokohama University of Pharmacy – sequence: 4 fullname: Nakano, Makoto organization: Department of Pharmacy, Yokohama University of Pharmacy |
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Cites_doi | 10.1146/annurev.nutr.23.011702.073247 10.3164/jcbn.08-245 10.3945/jn.114.197517 10.3945/jn.115.225631 10.3945/ajcn.111.012815 10.3177/jnsv.57.418 10.5264/eiyogakuzashi.69.285 10.1093/jn/129.10.1920 10.3164/jcbn.10-146 10.3945/jn.116.236331 10.1152/ajpendo.1993.264.4.E677 10.1136/adc.8.48.423 10.1371/journal.pone.0157406 10.1002/9780471722199 10.1017/S0007114512002504 10.1249/MSS.0000000000001366 10.1093/ajcn/86.4.995 10.1152/ajpendo.00174.2018 |
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Keywords | protein requirement indicator amino acid oxidation change-point regression model break-point inter-individual variability |
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SubjectTerms | Amino acids break-point change-point regression model Coefficient of variation Diet indicator amino acid oxidation inter-individual variability Invasiveness Mathematical analysis Nitrogen balance Original Oxidation protein requirement Proteins Regression analysis Regression models Variability Variation |
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Title | Estimation of inter-individual variability of protein requirement by indicator amino acid oxidation method |
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