Marked enhancement of the immune response to BioThrax® (Anthrax Vaccine Adsorbed) by the TLR9 agonist CPG 7909 in healthy volunteers - Rynkiewicz, Dianna; Rathkopf, Melinda; Sim, Iain; Waytes, A. Thomas; Hopkins, Robert J.; Giri, Lallan; DeMuria, Deborah; Ransom, Janet; Quinn, James; Nabors, Gary S.; Nielsen, Carl J. (Vaccine, 2011)
Keywords: Adjuvant; adjuvants; Adjuvants, Immunologic - administration & dosage; Adolescent; Adult; agonists; Allergy and Immunology; Aluminum; animals; Anthrax; Anthrax - immunology; Anthrax - prevention & control; Anthrax Vaccine Adsorbed; Anthrax Vaccines - administration & dosage; Anthrax Vaccines - adverse effects; Anthrax Vaccines - immunology; Antibodies, Bacterial - blood; Antibodies, Bacterial - immunology; Antibodies, Neutralizing - immunology; antigens; Antigens, Bacterial - immunology; Antimicrobial agents; Applied microbiology; Bacillus anthracis - immunology; Bacteriology; Biological and medical sciences; BioThrax; Blood products; blood serum; Clinical trial; clinical trials; CpG; CPG 7909; Deoxyribonucleic acid; disease control; Disease prevention; DNA; Double-Blind Method; Drug dosages; enzyme-linked immunosorbent assay; Female; Fundamental and applied biological sciences. Psychology; Hispanic Americans; Humans; Immune response; Immunization; Immunogenicity; immunoglobulin G; Immunoglobulin G - biosynthesis; Immunoglobulin G - blood; Immunoglobulin G - immunology; Male; Microbiology; Middle Aged; Miscellaneous; Oligodeoxynucleotide; oligodeoxyribonucleotides; Oligodeoxyribonucleotides - administration & dosage; Oligodeoxyribonucleotides - adverse effects; Oligodeoxyribonucleotides - immunology; Prophylaxis; spores; Substance abuse treatment; Toll-Like Receptor 9 - agonists; Toxins; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - adverse effects; Vaccines, Synthetic - immunology; volunteers; United States--US; Oligodeoxynucleotide; Anthrax Vaccine Adsorbed; CPG 7909; Clinical trial; Adjuvant; BioThrax; CpG; Bacillus anthracis; Immune response; Vaccine; Bacillaceae; Infection; Bacillales; Anthrax; Immunological adjuvant; Bacteriosis; Bacteria