Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears

• Published in: Scientific reports Vol. 10; no. 1; pp. 20323 - 15
• Main Authors: Ebert, Thomas, Painer, Johanna, Bergman, Peter, Qureshi, Abdul Rashid, Giroud, Sylvain, Stalder, Gabrielle, Kublickiene, Karolina, Göritz, Frank, Vetter, Sebastian, Bieber, Claudia, Fröbert, Ole, Arnemo, Jon M., Zedrosser, Andreas, Redtenbacher, Irene, Shiels, Paul G., Johnson, Richard J., Stenvinkel, Peter
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.11.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 631/601; 692/4022; Adult; Aged; Aged, 80 and over; Animal species; Animals; Bears; Betaine; Betaine - blood; Biomimetics; Biomimetics - methods; Captivity; Cardiovascular Diseases - etiology; Cardiovascular Diseases - mortality; Choline; Choline - blood; Eating behavior; Female; Gastrointestinal Microbiome; Hibernation; Hibernation - physiology; Humanities and Social Sciences; Humans; Kidney diseases; Lions - blood; Male; Metabolism; Metabolites; Methylamines - blood; Microbiota; Middle Aged; multidisciplinary; Myoxidae - blood; Prospective Studies; Renal function; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - complications; Science; Science (multidisciplinary); Shunts; Species; Sus scrofa - blood; Tigers - blood; Trimethylamine; Ursidae - blood; Zoologi; Zoology

Experimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney disease (CKD), in part via metabolism of ingested food. Using a comparative biomimetic approach, we have investigated circulating levels of the gut metabolites be...