Neurotoxicity of perfluorooctane sulfonate (PFOS) in rats and mice after single oral exposure

• Published in: Journal of toxicological sciences Vol. 34; no. 5; pp. 569 - 574
• Main Authors: Sato, Itaru, Kawamoto, Kosuke, Nishikawa, Yasuo, Tsuda, Shuji, Yoshida, Midori, Yaegashi, Kaori, Saito, Norimitsu, Liu, Wei, Jin, Yihe
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Toxicology 01.10.2009; Japan Science and Technology Agency
• Subjects: Administration, Oral; Alkanesulfonic Acids - administration & dosage; Alkanesulfonic Acids - toxicity; Animals; Brain - drug effects; Brain - metabolism; Convulsion; Environmental Pollutants - administration & dosage; Environmental Pollutants - toxicity; Fluorocarbons - administration & dosage; Fluorocarbons - toxicity; Mice; Mice, Inbred ICR; Neurotoxicity; Neurotransmitter Agents - metabolism; PFOA; PFOS; Rats; Rats, Wistar; Toxicity Tests

Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are widely used in industrial fields and consumer products, and are ubiquitously found in the environment and animal tissues. In the present study, their neurotoxicity was examined using rats and mice by means of neurobehavioral observat...