CircZFR involves propofol-triggered ferroptosis in lung cancer cells through the IGF2BP2/GPX4 axis

• Published in: Journal of investigative medicine p. 10815589251346947
• Main Authors: Yu, Xiaocui, Gu, Yuhui, Wang, Shao, Yin, Chunyang, Liao, Xin, Liao, Xucai
• Format: Journal Article
• Language: English
• Published: England 23.05.2025
• Subjects: lung cancer; GPX4-mediated ferroptosis; IGF2BP2; Propofol; circZFR

This study aims to delineate the underlying mechanism by which propofol triggers ferroptosis in lung cancer cells through the inhibition of the circZFR/IGF2BP2/GPX4 axis. The expression levels of circZFR, insulin-like growth factor 2 binding protein 2 (IGF2BP2), and glutathione peroxidase 4 (GPX4) i...