Effects of the GLP-1 receptor agonist lixisenatide on postprandial glucose and gastric emptying – preclinical evidence

• Published in: Journal of diabetes and its complications Vol. 28; no. 1; pp. 110 - 114
• Main Author: Werner, Ulrich
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2014; Elsevier Limited
• Subjects: Animals; Blood Glucose - drug effects; Blood Glucose - metabolism; Clinical Trials as Topic; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Digestive system; Drug Evaluation, Preclinical - statistics & numerical data; Endocrinology & Metabolism; Gastric emptying; Gastric Emptying - drug effects; GLP-1 receptor agonists; Glucagon-Like Peptide-1 Receptor; Humans; Lixisenatide; Peptides - pharmacology; Postprandial glucose; Postprandial Period - drug effects; Receptors, Glucagon - agonists; Rodents; Studies; Treatment Outcome; Type 2 diabetes mellitus; Weight control; Gastric emptying; Postprandial glucose; Type 2 diabetes mellitus; GLP-1 receptor agonists; Lixisenatide

In addition to promoting glucose homeostasis, glucagon-like peptide 1 (GLP-1) has a number of extra-pancreatic effects that regulate appetite and body weight. GLP-1 delays gastric emptying, which is vital for postprandial glucose (PPG) control. As GLP-1 is rapidly degraded by protease dipeptidyl pep...