A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

• Published in: Nature (London) Vol. 463; no. 7281; pp. 671 - 675
• Main Authors: Walters, R. G., Jacquemont, S., Valsesia, A., de Smith, A. J., Martinet, D., Andersson, J., Falchi, M., Chen, F., Andrieux, J., Lobbens, S., Delobel, B., Stutzmann, F., El-Sayed Moustafa, J. S., Chèvre, J.-C., Lecoeur, C., Vatin, V., Bouquillon, S., Buxton, J. L., Boute, O., Holder-Espinasse, M., Cuisset, J.-M., Lemaitre, M.-P., Ambresin, A.-E., Brioschi, A., Gaillard, M., Giusti, V., Fellmann, F., Ferrarini, A., Hadjikhani, N., Campion, D., Guilmatre, A., Goldenberg, A., Calmels, N., Mandel, J.-L., Le Caignec, C., David, A., Isidor, B., Cordier, M.-P., Dupuis-Girod, S., Labalme, A., Sanlaville, D., Béri-Dexheimer, M., Jonveaux, P., Leheup, B., Õunap, K., Bochukova, E. G., Henning, E., Keogh, J., Ellis, R. J., MacDermot, K. D., van Haelst, M. M., Vincent-Delorme, C., Plessis, G., Touraine, R., Philippe, A., Malan, V., Mathieu-Dramard, M., Chiesa, J., Blaumeiser, B., Kooy, R. F., Caiazzo, R., Pigeyre, M., Balkau, B., Sladek, R., Bergmann, S., Mooser, V., Waterworth, D., Reymond, A., Vollenweider, P., Waeber, G., Kurg, A., Palta, P., Esko, T., Metspalu, A., Nelis, M., Elliott, P., Hartikainen, A.-L., McCarthy, M. I., Peltonen, L., Carlsson, L., Jacobson, P., Sjöström, L., Huang, N., Hurles, M. E., O’Rahilly, S., Farooqi, I. S., Männik, K., Jarvelin, M.-R., Pattou, F., Meyre, D., Walley, A. J., Coin, L. J. M., Blakemore, A. I. F., Froguel, P., Beckmann, J. S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.02.2010; Nature Publishing Group
• Subjects: 631/208/2489/144; 631/208/737; 692/699/2743/393; Adolescent; Adult; Age of Onset; Aging; Autism; Biological and medical sciences; Body Mass Index; Case-Control Studies; Child; Chromosome Deletion; Chromosomes; Chromosomes, Human, Pair 16 - genetics; Cognition Disorders; Cognition Disorders - complications; Cognition Disorders - genetics; Cohort Studies; complications; Deletion; Europe; Female; Genetics; Genome-Wide Association Study; Genotype & phenotype; Heterozygote; Human; Humanities and Social Sciences; Humans; Inheritance Patterns; Inheritance Patterns - genetics; letter; Life Sciences; Loci; Male; Medical Genetics and Genomics; Medical sciences; Medicinsk genetik och genomik; Metabolic diseases; multidisciplinary; Mutation; Mutation - genetics; Nuclear power generation; Nucleotides; Obesity; Obesity - complications; Obesity - genetics; Obesity - physiopathology; Pair 16; Penetrance; Penetrants; physiopathology; Public health; Reproducibility of Results; Science; Science (multidisciplinary); Sex Characteristics; Studies; Young Adult; Europe; Deletion; Obesity; Chromosome; Nutritional status; Nutrition disorder

Genetic link to obesity Obesity is a highly heritable disorder but the genetic associations reported to date account for only a small percentage of the inherited variation in body mass index. Two groups report deletions on chromosome16p11.2 that may explain part of the 'missing heritability...